Calibration of analyte measurement system

Abstract

A method of calibrating an analyte measurement system is provided.

1 . A method of calibrating an in vivo analyte monitoring system, comprising:
 generating, by one or more processors of the in vivo analyte monitoring system, a signal from an analyte sensor having at least a portion inserted through a skin surface and in contact with a biofluid of a subject, the signal corresponding to an analyte concentration level in the biofluid;   determining, by the one or more processors, a stability of the generated signal based upon a rate of change of the signal over a period of time; and   calibrating, by the one or more processors, the generated signal from the analyte sensor if the determined stability of the generated signal is at or below a predetermined threshold.   
     
     
         2 . The method of  claim 1 , wherein the predetermined threshold is approximately 1 mg/dL/min. 
     
     
         3 . The method of  claim 1 , further comprising presenting an alarm on a user interface if the determined stability is above the predetermined threshold and the generated signal is below a second predetermined threshold. 
     
     
         4 . The method of  claim 3 , further comprising prompting the subject to perform a fingerstick calibration. 
     
     
         5 . The method of  claim 4 , further comprising confirming the determination of stability using the fingerstick calibration. 
     
     
         6 . The method of  claim 4 , further comprising identifying a condition using the fingerstick calibration. 
     
     
         7 . The method of  claim 6 , wherein the condition is a hypoglycemic event. 
     
     
         8 . The method of  claim 1 , wherein the stability of the generated signal is determined after a reference duration after sensor insertion. 
     
     
         9 . The method of  claim 8 , wherein the reference duration ranges from about 2 hours to about 12 hours. 
     
     
         10 . The method of  1 , wherein the stability of the generated signal is determined a reference duration after the sensor insertion and after confirming that sensor performance has stabilized. 
     
     
         11 . The method of  claim 10 , wherein the sensor performance has stabilized if an Early Sensitivity Attenuation (ESA) module shows a high probability of 90%, 95%, or 100%. 
     
     
         12 . An in vivo analyte monitoring system, comprising:
 an in vivo analyte sensor configured to generate a signal corresponding to an analyte concentration level in a biofluid of a subject, wherein at least a portion of the analyte sensor has been inserted through a skin surface in contact with the biofluid;   one or more processors;   a memory storing instructions which, when executed by the one or more processors, causes the one or more processors to:
 generate, by the one or more processors, the signal indicative of the analyte concentration level in the biofluid of the subject; 
 determine, by the one or more processors, a stability of the generated signal based upon a rate of change of the signal over a period of time; and 
 calibrate, by the one or more processors, the generated signal from the analyte sensor if the determined stability of the generated signal is at or below a predetermined threshold. 
   
     
     
         13 . The apparatus of  claim 12 , wherein the predetermined threshold is approximately 1 mg/dL/min. 
     
     
         14 . The apparatus of  claim 12 , further comprising a user interface, and wherein the instructions further cause the one or more processors to present an alarm to the subject if the determined stability is above the predetermined threshold and the generated signal is below a second predetermined threshold. 
     
     
         15 . The apparatus of  claim 14 , wherein the instruction further cause the one or more processors to prompt the subject to perform a fingerstick calibration. 
     
     
         16 . The apparatus of  claim 15 , wherein the instructions further cause the one or more processors to identify a condition using the fingerstick calibration. 
     
     
         17 . The apparatus of  claim 12 , wherein the stability of the generated signal is determined after a reference duration after sensor insertion. 
     
     
         18 . The apparatus of  claim 17 , wherein the reference duration ranges from about 2 hours to about 12 hours. 
     
     
         19 . The apparatus of  claim 12 , wherein the stability of the generated signal is determined a reference duration after the sensor insertion and after confirmation that sensor performance has stabilized. 
     
     
         20 . The apparatus of  claim 19 , wherein the sensor performance has stabilized if an Early Sensitivity Attenuation (ESA) module shows a high probability of 90%, 95%, or 100%.