US2023063741A1PendingUtilityA1
IL-22 POLYPEPTIDES AND IL-22 Fc FUSION PROTEINS AND METHODS OF USE
Est. expiryMar 15, 2033(~6.6 yrs left)· nominal 20-yr term from priority
Inventors:Justin ScheerWenjun OuyangRichard VandlenPhilip E. HassEric Gary StefanichGanesh A. KolumamXiaoting WangJed RossNicholas Van BruggenWyne P. Lee
A61P 39/02A61K 38/20C07K 14/54A61P 31/04A61P 9/12A61P 13/12A61P 43/00C07K 16/2866A61P 9/00A61P 17/02A61K 38/00A61K 47/38A61P 1/04A61P 3/00A61P 9/10C07K 2319/30A61P 3/04A61P 3/10A61P 3/06
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Claims
Abstract
The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
Claims
exact text as granted — not AI-modified1 . An IL-22 Fc fusion protein that binds to IL-22 receptor, said IL-22 Fc fusion protein comprising an IL-22 polypeptide linked to an Fc region by a linker, wherein the Fc region comprises a hinge region, an IgG CH2 domain and an IgG CH3 domain, wherein the IL-22 Fc fusion protein comprises an amino acid sequence having at least 95% sequence identity to the amino acid sequence selected from the group consisting of SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12 and SEQ ID NO:14, and wherein the Fc region is not glycosylated.
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