Injection device and injection solution transferring system

Abstract

The present disclosure relates to an injection device, in particular a micro dose injection device such as, for example, an ophthalmic injection device. An example device comprises a rotatable plunger; a solution receptacle having a first end configured to slidably receive the rotatable plunger and a second end configured to dispense solution contained in the solution receptacle; a first stop member configured to prevent the rotatable plunger from being slidably displaced to a second position while the rotatable plunger is at a first position and in a first orientation; and a second stop member configured to prevent the rotatable plunger from rotating in a first direction about the first axis while the rotatable plunger is at the first position and in the first orientation, wherein slidably displacing the rotatable plunger from the first position to the second position dispenses a quantity of the solution contained in the solution receptacle.

1 . A solution dispensing device, comprising:
 a rotatable plunger;   a solution receptacle having a first end configured to slidably receive the rotatable plunger and a second end configured to dispense solution contained in the solution receptacle, wherein the solution dispensing device is configured to:
 allow the rotatable plunger, while it is in a first orientation, to be slidably displaced along a first axis to be positioned at a first position relative to the solution receptacle, and 
 allow the rotatable plunger, while it is in a second orientation, to be slidably displaced along the first axis from the first position to a second position relative to the solution receptacle, wherein:
 the second position is closer to the second end of the solution receptacle than the first position, and 
 slidably displacing the rotatable plunger from the first position to the second position dispenses a quantity of the solution contained in the solution receptacle; 
 
   a first stop member configured to prevent the rotatable plunger from being slidably displaced to the second position while the rotatable plunger is at the first position and in the first orientation; and   a second stop member configured to prevent the rotatable plunger from rotating in a first direction about the first axis while the rotatable plunger is at the first position and in the first orientation.   
     
     
         2 . The solution dispensing device of  claim 1 , further comprising:
 a third stop member configured to prevent the rotatable plunger from rotating in a second direction about the first axis while the rotatable plunger is at the first position and in the second orientation.   
     
     
         3 . The solution dispensing device of  claim 1 , wherein the first stop member is positioned on the rotatable plunger. 
     
     
         4 . The solution dispensing device of  claim 3 , wherein the second stop member is positioned on the rotatable plunger. 
     
     
         5 . The solution dispensing device of  claim 1  , further comprising:
 a housing configured to releasably connect to the solution receptacle, wherein the housing includes a plunger through-hole that is configured to slidably receive the rotatable plunger and to allow the solution receptacle to slidably receive the rotatable plunger. 
 
     
     
         6 . The solution dispensing device of  claim 5 , wherein the first stop member is positioned on a top surface of the housing, and wherein the first stop member projects from the top surface of the housing in a proximal direction along the first axis. 
     
     
         7 . The solution dispensing device of  claim 5  , wherein the second stop member is positioned on the top surface of the housing, and wherein the second stop member projects from the top surface of the housing in the proximal direction along the first axis. 
     
     
         8 . The solution dispensing device of  claim 5  , wherein the first stop member has a first height relative to the top surface of the housing, and wherein the quantity of the solution that is dispensed when the rotatable plunger is slidably displaced from the first position to the second position is based at least in part on the first height. 
     
     
         9 . The solution dispensing device of  claim 8 , wherein the second stop member has a second height relative to the top surface of the housing that is greater than the first height. 
     
     
         10 . The solution dispensing device of  claim 5  , wherein an outer surface of the solution receptacle includes a clip receiver element,
 wherein the housing includes a housing clip, and 
 wherein the housing clip releasably connects to the clip receiver element. 
 
     
     
         11 . The solution dispensing device of  claim 10 , wherein the first end of the solution receptacle includes a flange element, and wherein the housing is configured to slidably receive the flange element when the housing clip releasably connects to the clip receiver element. 
     
     
         12 . The solution dispensing device of  claim 1  , wherein the rotatable plunger includes a flange,
 wherein the flange contacts the first stop member and prevents the rotatable plunger from being slidably displaced to the second position while the rotatable plunger is at the first position and in the first orientation, and 
 wherein the flange contacts the second stop member and prevents the rotatable plunger from rotating about the first axis in the first direction while the rotatable plunger is at the first position and in the first orientation. 
 
     
     
         13 . The solution dispensing device of  claim 1  , wherein the solution dispensing device is configured to prevent the rotatable plunger from rotating about the first axis until the rotatable plunger is positioned at the first position. 
     
     
         14 . The solution dispensing device of  claim 1  , wherein the quantity of solution dispensed when the rotatable plunger is slidably displaced from the first position to the second position is selected from the group consisting of 5 µL, 10 µL, and 20 µL. 
     
     
         15 . The solution dispensing device of  claim 1  , wherein an inner surface of the solution receptacle is coated with a plasma-enhanced chemical vapor deposition (PECVD) coating, and wherein the PECVD coating imparts a lubricity layer on the inner surface. 
     
     
         16 . The solution dispensing device of  claim 1  , wherein the inner surface of the solution receptacle is coated with a lubricant coating created from a PECVD process that uses octamethylcyclotetrasiloxane (OMCTS) as a precursor. 
     
     
         17 . The solution dispensing device of  claim 1  , wherein the solution receptacle is manufactured via a PECVD process that uses radiofrequency power comprised of silicon, carbon, and oxygen under at least ISO class 8 conditions while in operation and ISO class 7 conditions at rest according to ISO 14644. 
     
     
         18 . A method for dispensing solution from a solution dispensing device, the solution dispensing device having a rotatable plunger, a solution receptacle, a first stop member, and a second stop member, the method comprising:
 slidably inserting the rotatable plunger into a first end of the solution receptacle, wherein a second end of the solution receptacle is configured to dispense a solution contained in the solution receptacle;   while the rotatable plunger is in a first orientation, slidably displacing the rotatable plunger along a first axis until the rotatable plunger is in a first position relative to the solution receptacle, wherein:
 the first stop member prevents the rotatable plunger from being slidably displaced to a second position relative to the solution receptacle that is closer to the second end of the solution receptacle than the first position while the rotatable plunger is at the first position and in the first orientation, and 
 the second stop member prevents the rotatable plunger from rotating in a first direction about the first axis while the rotatable plunger is at the first position and in the first orientation; 
   rotating the rotatable plunger in a second direction about the first axis until the rotatable plunger is in a second orientation at the first position; and   while the rotatable plunger is in the second orientation, slidably displacing the rotatable plunger along the first axis until the rotatable plunger is in the second position relative to the solution receptacle, wherein slidably displacing the rotatable plunger from the first position to the second position dispenses a quantity of the solution contained in the solution receptacle.   
     
     
         19 . The method of  claim 18 , wherein a third stop member prevents the rotatable plunger from rotating in the second direction about the first axis while the rotatable plunger is at the first position and in the second orientation. 
     
     
         20 . The method of  claim 18  , wherein the first stop member is positioned on the rotatable plunger. 
     
     
         21 . The method of  claim 18  , wherein the second stop member is positioned on the rotatable plunger. 
     
     
         22 . The method of  claim 18  , wherein the solution dispensing device further includes a housing configured to releasably connect to the solution receptacle, wherein the housing includes a plunger through-hole that is configured to slidably receive the rotatable plunger and to allow the solution receptacle to slidably receive the rotatable plunger. 
     
     
         23 . The method of  claim 22 , wherein the first stop member is positioned on the housing. 
     
     
         24 . The method of  claim 22  , wherein the second stop member is positioned on the housing. 
     
     
         25 . The method of  claim 22  , wherein the first stop member has a first height, and wherein the quantity of the solution that is dispensed when the rotatable plunger is slidably displaced from the first position to the second position is based at least in part on the first height. 
     
     
         26 . The method of  claim 18  , wherein the rotatable plunger includes a flange,
 wherein the flange contacts the first stop member and prevents the rotatable plunger from being slidably displaced to the second position while the rotatable plunger is at the first position and in the first orientation, and 
 wherein the flange contacts the second stop member and prevents the rotatable plunger from rotating about the first axis in the first direction while the rotatable plunger is at the first position and in the first orientation. 
 
     
     
         27 . The method of  claim 18  , wherein the solution dispensing device is configured to prevent the rotatable plunger from rotating about the first axis until the rotatable plunger is positioned at the first position. 
     
     
         28 . The method of  claim 18  , wherein the quantity of solution dispensed when the rotatable plunger is slidably displaced from the first position to the second position is selected from the group consisting of 5 µL, 10 µL, and 20 µL. 
     
     
         29 . The method of  claim 18  , wherein the solution receptacle contains between 100 µL to 1000 µL of the solution. 
     
     
         30 . The method of  claim 18  , wherein the quantity of solution dispensed when the rotatable plunger is slidably displaced from the first position to the second position is between 2.5% and 12.5% of the solution contained in the solution receptacle. 
     
     
         31 . The method of  claim 18  , wherein the solution contains a vascular endothelial growth factor (VEGF) antagonist. 
     
     
         32 . The method of  claim 18  , wherein the solution contains Beovu® (brolucizumab). 
     
     
         33 . The method of  claim 18  , wherein the solution contains Eylea® (aflibercept). 
     
     
         34 . The method of  claim 18  , wherein the solution contains Luxturna® (Voretigene neparvovec). 
     
     
         35 . The method of  claim 18  , wherein the solution contains nucleic acids. 
     
     
         36 . The method of  claim 18  , wherein the method is used for a pediatric ophthalmic injection. 
     
     
         37 . The method of  claim 18  , wherein the method is used for gene therapy.