US2023028588A1PendingUtilityA1

Pharmaceutical combination for use in glycemic control in diabetes type 2 patients

Assignee: SANOFI AVENTIS DEUTSCHLANDPriority: Aug 29, 2011Filed: May 9, 2022Published: Jan 26, 2023

Est. expiryAug 29, 2031(~5.1 yrs left)· nominal 20-yr term from priority

Inventors:Elisabeth Niemoeller Isabel Muehlen-Bartmer Louise Silvestre Gabor Boka Patrick Miossec

A61K 31/4439A61K 31/155A61K 38/26A61K 31/427A61P 3/10A61P 43/00

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Claims

Abstract

The present invention refers to a pharmaceutical combination for use in glycemic control in diabetes type 2 patients.

Claims

exact text as granted — not AI-modified

1 : A method for improving glycemic control in a patient with type 2 diabetes not adequately controlled by treatment with a glitazone, the method comprising administering to the patient in need thereof a pharmaceutical combination comprising;
 (a) insulin glargine at a dose of 15 U/day to 60 U/day;   (b) lixisenatide at a dose of 10 μg/day to 20 μg/day, and   (c) a glitazone at a dose of 10 mg/day to 60 mg/day.   
     
     
         2 : The method of  claim 1 , wherein the pharmaceutical combination further comprises: (d) metformin at a dose of 1.0 g/day to 1.5 g/day. 
     
     
         3 : The method of  claim 1 , wherein the patient is inadequately controlled by treatment with a combination of glitazone and metformin. 
     
     
         4 : The method of  claim 1 , wherein the glitazone is pioglitazone.

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