US2023000768A1PendingUtilityA1

Polymeric emulsion delivery systems

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Assignee: BAUSCH HEALTH IRELAND LTDPriority: Apr 5, 2018Filed: May 18, 2022Published: Jan 5, 2023
Est. expiryApr 5, 2038(~11.7 yrs left)· nominal 20-yr term from priority
Inventors:Arturo AngelChandelle Hermes
A61K 31/4436C08L 33/02A61K 31/203A61K 9/06C08L 33/064A61K 9/0014A61K 31/573A61K 47/32A61P 17/10A61K 9/107
60
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Claims

Abstract

Provided herein are compositions comprising an oil-in-water emulsion, wherein the emulsion comprises a liquid oil component; a cross-linked homopolymer based on acrylic acid and/or a cross-linked copolymer of acrylic acid and acrylic acid esters; and water. In some embodiments, the composition is a vehicle for the delivery of an active agent.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A topical composition comprising:
 a liquid oil component;   a cross-linked homopolymer based on acrylic acid as a first emulsifier, and   water;   wherein the composition forms a stable oil-in-water emulsion.   
     
     
         2 . The topical composition of  claim 1 , wherein the liquid oil component is present in an amount of about 30% or less by weight of the composition. 
     
     
         3 . The topical composition of  claim 2 , wherein the liquid oil component is present in an amount of about 20% or less by weight of the composition. 
     
     
         4 . The topical composition of any of  claims 1  to  3 , wherein the first emulsifer is present in an amount of about 0.01-5% by weight of the composition. 
     
     
         5 . The topical composition of  claim 4 , wherein the first emulsifier is present in an amount of about 0.01-3% by weight of the composition. 
     
     
         6 . The topical composition of any of  claims 1  to  5 , wherein the ratio of the amount of the liquid oil component to that of the first emulsifer is in the range of about 1:1 to about 28:1. 
     
     
         7 . The topical composition of  claim 6 , wherein the ratio of the amount of the liquid oil component to that of the first emulsifer is in the range of about 1:1 to about 20:1. 
     
     
         8 . The topical composition of  claim 6  or  7 , wherein the ratio of the amount of the liquid oil component to that of the first emulsifier is in the range of about 3:1 to about 10:1. 
     
     
         9 . The topical composition of any of  claims 1  to  8 , wherein first emulsifer is a carbomer homopolymer type A and/or a carbomer homopolymer type C. 
     
     
         10 . The topical composition of any of  claims 1  to  9 , wherein the liquid oil component comprises mineral oil, light mineral oil, a fatty alcohol, a monocarboxylic acid ester, a dicarboxylic acid ester, a medium chain triglyceride, a long chain triglyceride, or a combination thereof. 
     
     
         11 . The topical composition of any of  claims 1  to  10 , wherein the composition further comprises a surfactant or a cross-linked copolymer of acrylic acid and acrylic acid esters as a second emulsifier. 
     
     
         12 . The topical composition of  claim 11 , wherein the second emulsifier is a cross-linked copolymer of acrylic acid and acrylic acid esters, present in an amount of about 0.01-3% by weight of the composition. 
     
     
         13 . The topical composition of  claim 11  or  12 , wherein the second emulsifer is a carbomer copolymer type B and/or a carbomer copolymer type A. 
     
     
         14 . The topical composition of  claim 11 , wherein the composition further comprises a nonionic, anionic, or cationic surfactant in an amount up to about 0.5% by weight of the composition. 
     
     
         15 . The topical composition of  claim 14 , wherein the nonionic surfactant is selected from the group consisting of sorbitan esters, polyoxyethytene derivatives of a sorbitan ester, glyceryl monostearate, polyoxyethylene monooleate, polyoxyethylene monostearate and polyoxyethylene monolaurate. 
     
     
         16 . The topical composition of  claim 14 , wherein the anionic surfactant is selected from the group consisting of an alkali soap, an amine soap, and a detergent. 
     
     
         17 . The topical composition of  claim 14 , wherein the cationic surfactant is selected from the group consisting of quaternium ammonium salts and quaternary amine salts. 
     
     
         18 . The topical composition of any of  claims 1  to  10 , wherein the composition does not comprise a second emulsifier. 
     
     
         19 . The topical composition of any of  claims 1  to  18 , wherein the oil-in-water emulsion is stable for at least 24 hours at 40° C. 
     
     
         20 . The topical composition of any of  claims 1  to  19 , further comprising an active agent. 
     
     
         21 . The topical composition of  claim 20 , comprising two or more active agents. 
     
     
         22 . A topical composition, wherein the composition comprises an oil-in-water emulsion, wherein the emulsion comprises:
 a liquid oil component, wherein the liquid oil component is in an amount of about 30% or less by weight of the composition;   a polymer selected from the group consisting of a cross-linked homopolymer based on acrylic acid in an amount of about 0.01-5% by weight of the composition, a cross-linked copolymer of acrylic acid and acrylic acid esters in an amount of about 0.01-5% by weight of the composition, and combinations thereof; and   water.   
     
     
         23 . The topical composition of  claim 22 , wherein the liquid oil component is present in an amount of about 20% or less by weight of the composition. 
     
     
         24 . The topical composition of  claim 22  or  23 , wherein the composition comprises a cross-linked homopolymer based on acrylic acid in an amount of about 0.01-3% by weight of the composition. 
     
     
         25 . The topical composition of  claim 22  or  23 , wherein the composition comprises a cross-linked copolymer of acrylic acid and acrylic acid esters in an amount of about 0.01-3% by weight of the composition. 
     
     
         26 . The topical composition of any of  claims 22  to  25 , wherein the ratio of the amount of the liquid oil component to that of the polymer is in the range of about 1:1 to about 28:1. 
     
     
         27 . The topical composition of  claim 26 , wherein the ratio of the amount of the liquid oil component to that of the polymer is in the range of about 1:1 to about 20:1. 
     
     
         28 . The topical composition of  claim 26  or  27 , wherein the ratio of the amount of the liquid oil component to that of the polymer is in the range of about 3:1 to about 10:1. 
     
     
         29 . The topical composition of any of  claims 22  to  28 , wherein the liquid oil component comprises mineral oil, light mineral oil, a fatty alcohol, a monocarboxylic acid ester, a dicarboxylic acid ester, a medium chain triglyceride, a long chain triglyceride, or a combination thereof. 
     
     
         30 . The topical composition of any of  claims 22 ,  23 , or  26  to  29 , wherein the polymer is a cross-linked homopolymer based on acrylic acid. 
     
     
         31 . The topical composition of  claim 30 , wherein the cross-linked homopolymer based on acrylic acid is a carbomer homopolymer type A, a carbomer homopolymer type B, or a carbomer homopolymer type C. 
     
     
         32 . The topical composition of  claim 31 , wherein the carbomer homopolymer is a carbomer homopolymer type A. 
     
     
         33 . The topical composition of any of  claims 22 ,  23 , or  26  to  29 , wherein the polymer is a cross-linked copolymer of acrylic acid and acrylic acid esters. 
     
     
         34 . The topical composition of  claim 33 , wherein the cross-linked copolymer of acrylic acid and acrylic acid esters is a carbomer copolymer type B and/or a carbomer copolymer type A. 
     
     
         35 . The topical composition of any of  claims 22 ,  23 , or  26  to  29 , wherein the polymer is a combination of a cross-linked homopolymer based on acrylic acid and a cross-linked copolymer of acrylic acid and acrylic acid esters. 
     
     
         36 . The topical composition of  claim 35 , wherein the polymer is a combination of a carbomer homopolymer type A and a carbomer copolymer type B. 
     
     
         37 . The topical composition of  claim 35 , wherein the ratio of the amount of the cross-linked homopolymer based on acrylic acid to that of the cross-linked copolymer of acrylic acid and acrylic acid esters is in the range of 0.1:1 to about 100:1. 
     
     
         38 . The topical composition of  claim 37 , wherein the ratio of the amount of the cross-linked homopolymer based on acrylic acid to that of the cross-linked copolymer of acrylic acid and acrylic acid esters is in the range of 1.6:1 to about 100:1. 
     
     
         39 . The topical composition of any of  claims 22  to  37 , further comprising an active agent. 
     
     
         40 . The topical composition of  claim 39 , comprising two or more active agents.

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