Nanoemulsion compositions for treating aeroallergen associated allergy and inflammation

Abstract

The disclosure is directed to compositions and methods for treating aeroallergen induced inflammation (e.g., airway inflammation). The compositions comprise a nanoemulsion and one or more aeroallergens.

1 . A composition comprising a nanoemulsion and one or more aeroallergens. 
     
     
         2 . The composition of  claim 1 , wherein the one or more aeroallergens are selected from pollen, mold spores, food, dust mites, cockroach allergen, animal hair, animal urine, dust, and cosmetics. 
     
     
         3 . The composition of  claim 1 , wherein the nanoemulsion comprises:
 (a) a poloxamer surfactant or polysorbate surfactant;   (b) an organic solvent;   (c) a halogen-containing compound;   (d) oil, and   (e) water.   
     
     
         4 . The composition of  claim 3 , wherein the nanoemulsion comprises:
 a) about 3 vol. % to about 15 vol. % of a poloxamer surfactant or polysorbate surfactant;   b) about 3 vol. % to about 15 vol. % of an organic solvent;   c) about 0.5 vol. % to about 1 vol. % of a halogen-containing compound;   d) about 3 vol. % to about 90 vol. % of an oil; and   e) about 5 vol. % to about 60 vol. % of water.   
     
     
         5 . A method of treating allergic airway inflammation in a subject, which comprises administering an effective amount of a composition comprising a nanoemulsion and one or more aeroallergens to a subject in need thereof, whereupon the allergic airway inflammation in the subject is treated. 
     
     
         6 . The method of  claim 5 , wherein the subject is a human. 
     
     
         7 . The method of  claim 6 , wherein the human suffers from asthma, allergic rhinitis, food allergy, or drug allergy. 
     
     
         8 . The method of  claim 5 , wherein the expression of Th2 type cytokines is reduced in the subject. 
     
     
         9 . The method of  claim 5 , wherein the composition is administered to the subject intranasally.