Method of treating disease

Abstract

The present disclosure relates to methods for treating a variety of diseases and/or ameliorating pain by administering to the ear canal of a subject a composition.

What is claimed is: 
     
         1 . A method for ameliorating pain in a subject, the method comprising administering to an ear canal of a subject afflicted with a distal pain an effective amount of a pharmaceutical composition comprising at least one anesthetic comprising Formula I: 
       
         
           
           
               
               
           
         
         wherein R 1  comprises: 
       
       
         
           
           
               
               
           
         
         wherein R 2  comprises H, CH 3 , Cl, or 
       
       
         
           
           
               
               
           
         
         wherein R 3  comprises H or NH 2 ; 
         wherein R 4  comprises H, NH 2 , CH 3 , 
       
       
         
           
           
               
               
           
         
         wherein R 5  comprises H; and wherein R 6  comprises H or CH 3 . 
       
     
     
         2 . The method according to  claim 1 , wherein the anesthetic comprises benzocaine, chloroprocaine, cocaine, cyclomethycaine, dimethocaine, larocaine, piperocaine, propoxycaine, procaine, novocaine, proparacaine, tetracaine, amethocaine, articaine, bupivacaine, cinchocaine, dibucaine, etidocaine, levobupivacaine, lidocaine, lignocaine, mepivacaine, prilocaine, ropivacaine, farmocaine, trimecaine, or a combination of the anesthetics listed herein. 
     
     
         3 . The method of  claim 1 , wherein the composition further comprises at least one analgesic comprising a pyrazolone derivative. 
     
     
         4 . The method of  claim 3 , wherein the pyrazolone derivative is selected from the group consisting of ampyrone, dipyrone, antipyrine, aminopyrine, and propyphenazone. 
     
     
         5 . The method of  claim 1 , wherein said pharmaceutical composition is administered in a concentration sufficient to physiologically alter the activity of the subject's particular cranial nerve compared to the physiological activity of that particular cranial nerve in a subject not administered the pharmaceutical composition. 
     
     
         6 . The method according to  claim 5 , wherein the particular cranial nerve is the trigeminal nerve, the facial nerve, the glossopharyngeal nerve, the accessory nerve, the hypoglossal nerve, the vagus nerve, or a combination thereof. 
     
     
         7 . The method according to  claim 1 , wherein the subject does not have an ear infection, ear pain, or a combination thereof. 
     
     
         8 . The method according to  claim 1 , wherein the pharmaceutical composition further comprises one or more of an antibiotic, a vasoconstrictor, glycerin, epinephrine, or acetic acid. 
     
     
         9 . The method according to  claim 1 , wherein the amount of anesthetic does not exceed 252 mg/day. 
     
     
         10 . The method of  claim 3 , wherein the amount of analgesic administered does not exceed 972 mg/day. 
     
     
         11 . The method of  claim 1 , wherein the pain comprises post-tonsillectomy pharyngeal or oropharyngeal pain, post-adenoidectomy pharyngeal or oropharyngeal pain, laryngeal pain, migraine pain, anxiety headaches, peripheral neuropathy, neck and shoulder pain, general somatic afferent pain, neuromuscular pain, joint pain, sciatica pain, arthritis pain, shingles pain, reflex sympathetic dystrophy pain, general visceral afferent pain, post tonsillectomy pain, pharyngeal pain, laryngeal pain, neck pain, trigeminal neuralgia pain, temporomandibular joint pain, pelvic pain, chronic prostatitis pain, cystitis pain, kidney pain, gastritis pain, gall bladder pain, and pancreatitis pain. 
     
     
         12 . A method for treating a subject suffering from an affliction associated with a particular cranial nerve, the method comprising administering to an ear canal of a subject an effective amount of a pharmaceutical composition comprising at least one anesthetic comprising Formula I: 
       
         
           
           
               
               
           
         
         wherein R 1  comprises: 
       
       
         
           
           
               
               
           
         
         wherein R 2  comprises H, CH 3 , Cl, or 
       
       
         
           
           
               
               
           
         
         wherein R 3  comprises H or NH 2 ; 
         wherein R 4  comprises H, NH 2 , CH 3 , 
       
       
         
           
           
               
               
           
         
         wherein R 5  comprises H; and wherein R 6  comprises H or CH 3 . 
       
     
     
         13 . The method of  claim 12 , wherein the composition further comprises at least one analgesic comprising a pyrazolone derivative. 
     
     
         14 . The method of  claim 12 , wherein the affliction comprises a neurology-psychiatry-related affliction, ear-nose-throat (ENT)-related affliction, Gastroenterology/Urology (GU)-related affliction, gastrointestinal (GI)-related affliction, cardiac-related affliction, pulmonary-related affliction, metabolic-related affliction, infection-related affliction, skin-related affliction, cell proliferation-related affliction, or blood flow-related affliction. 
     
     
         15 . The method of  claim 14 , wherein the neurology-psychiatry-related affliction is at least one selected from the group consisting of: chronic fatigue syndrome, fibromyalgia, epilepsy, Obsessive Compulsive Disorder, panic attack, Post-Traumatic Stress Disorder, Tourette's Syndrome, Focal Dystonia, Tic Doloreaux, Bulimia, Anxiety, Depression, Restless Leg Syndrome, Dysautonomia, Familial Intentional Tremor, Migraine pain, Autism Spectrum Disorder, Anxiety Headache, sleeplessness, Reticular Activating System (RAS) dysregulation, Multiple Sclerosis, Peripheral Neuropathy, Apraxia, Neck and Shoulder Pain, Parkinson's Disease, General Somatic Afferent Pain, General Visceral, Afferent Pain, opiate withdrawal, Dysarthria, ADHD, Nonspecific hand tremor, Stuttering, cerebral palsy, Raynaud's Phenomenon, excessive sweating, reflex sympathetic dystrophy, sensory processing disorder, and decreased libido. 
     
     
         16 . The method of  claim 14 , wherein the ear-nose-throat (ENT)-related affliction is at least one selected from the group consisting of: Palatal Myoclonus, Post Tonsillectomy Pain, Pharyngeal Pain, Laryngeal Pain, Neurogenic Cough, Globus Hystericus, Spasmodic Dysphonia, Snoring, Allergic Rhinitis, Chronic Sinusitis, Chronic Nasal Congestion, Allergic Conjunctivitis, Sneezing, Hiccups, Rhinitis, Tinnitus, Dysphagia, neck pain, Dry Eye Syndrome, Trigeminal Neuralgia pain, and Temporomandibular Joint Pain. 
     
     
         17 . The method of  claim 14 , wherein the Gastroenterology/Urology (GU)-related affliction is at least one selected from the group consisting of: bladder spasm, dysmenorrhea, pelvic pain, Premature Labor, interstitial cystitis, Prostatitis, Eclampsia, pre-eclampsia, HELLP Syndrome, cystitis, Kidney Pain, enuresis, dysuria, dyspareunia, encopresis, heavy flow menstruation, frequent urination, Prolonged Vaginal Bleeding, decreased renal blood flow, chronic renal failure. 
     
     
         18 . The method of  claim 14 , wherein the gastrointestinal (GI)-related affliction is at least one selected from the group consisting of: irritable bowel syndrome (IBS), ulcerative colitis, acid reflux, Gastritis, Gastroenteritis, Hyperemesis Gravidarum, Pediatric Colic, Hepato-Renal Syndrome, Appetite Suppression, Gall Bladder Pain, Chronic constipation, Chronic diarrhea, and Pancreatitis. 
     
     
         19 . The method of  claim 14 , wherein the cardiac-related affliction is at least one selected from the group consisting of: Paroxysmal (Lone) (Vagal) Atrial Fibrillation, Orthostatic (Neurogenic) Hypotension, Reflex Asystolic Syncope, Postural Orthostatic Tachycardia Syndrome (POTS), Vasovagal Reflex, cardiac surgery derived cough, heart block, Atrial Contractions, Tachycardia, Congestive Heart Failure, premature atrial contraction, and atrial tachycardia. 
     
     
         20 . The method of  claim 14 , wherein the pulmonary-related affliction is at least one selected from the group consisting of: asthma, chronic obstructive pulmonary disease (COPD), bronchitis, cystic fibrosis, and Bronchospasm. 
     
     
         21 . The method of  claim 14 , wherein the metabolic-related affliction is at least one selected from the group consisting of: hypertension, diabetes, septic shock, neurogenic shock, hyperglycemia, hypercholesteremia, and insulin resistance. 
     
     
         22 . The method of  claim 14 , wherein the infection-related affliction is at least one selected from the group consisting of: Herpes Simplex 1 infection, Herpes, Simplex 2 infection, and Varicella Zoster infection. 
     
     
         23 . The method of  claim 14 , wherein the skin-related affliction is at least one selected from the group consisting of: facial flushing, facial blushing, alopecia areata, atopic dermatitis, chronic eczema, acne vulgaris, oily skin, rosacea, and morgellons disease. 
     
     
         24 . The method of  claim 14 , wherein the cell proliferation-related affliction is at least one selected from the group consisting of: cancer and mastocytosis. 
     
     
         25 . The method of  claim 14 , wherein the blood flow-related affliction is at least one selected from the group consisting of erectile dysfunction, open wound healing, and sickle cell disease.