Compounds having rd targeting motifs and methods of use thereof

Abstract

The present invention provides compounds that have motifs that target the compounds to cells that express integrins. In particular, the compounds have peptides with one or more RD motifs conjugated to an agent selected from an imaging agent and a targeting agent. The compounds may be used to detect, monitor, and treat a variety of disorders mediated by integrins.

What is claimed is: 
     
         1 . A compound having the formula:
   R 1 —[X 1   m —R-D-X 2   p ] n —Y—R 2  
   wherein:
 R 1  is a carbocyanine dye or derivative thereof; 
 R 2  is selected from the group consisting of a treatment agent, hydrogen, hydroxyl, NH 2 , hydrocarbyl, and substituted hydrocarbyl; 
 X 1   m —R-D-X 2   p  together form a linear or cyclic peptide; 
 X 1  and X 2  are independently selected from any amino acid residue; 
 m is an integer from 1 to about 10; 
 n is an integer from 1 to about 10; 
 p is an integer from 1 to about 10; and 
 a dash (—) represent a covalent bond.