US2022378819A1PendingUtilityA1

Compositions and methods for aerodigestive treatment

Assignee: WIAB WATER INNOVATION ABPriority: Feb 17, 2012Filed: Jun 16, 2022Published: Dec 1, 2022
Est. expiryFeb 17, 2032(~5.5 yrs left)· nominal 20-yr term from priority
C01B 11/04A61K 9/0014A61K 31/19A61K 33/20A61K 2300/00
73
PatentIndex Score
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Claims

Abstract

Disinfecting compositions containing hypochlorous acid and acetic acid are useful for treating biofilms in or on tissue, including treating and regulating the aerodigestive tract. The compositions are useful for treating a variety of types of tissue, both on the surface on beneath the surface of tissue. Compositions are provided having various concentrations for different types of infections. Compositions may be provided in droplet, aerosol, gel, or powder form.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A composition for aerodigestive administration, the composition comprising hypochlorous acid, acetic acid and an acceptable carrier, adjuvant, or diluent in a substantially air-free container. 
     
     
         2 . The composition of  claim 1 , wherein said carrier is water. 
     
     
         3 . The composition of  claim 1 , wherein said carrier is an electrolyte composition. 
     
     
         4 . The composition of  claim 1 , wherein said composition is formulated so as to be aerosolized upon use. 
     
     
         5 . The composition of  claim 4 , wherein said composition is a nasal spray. 
     
     
         6 . The composition of  claim 5 , wherein said carrier is saline. 
     
     
         7 . The composition of  claim 1 , wherein the composition is substantially free of chlorine gas. 
     
     
         8 . The nasal spray composition of  claim 1 , wherein the composition is buffered and has a pH approximately equal to a pKa of acetic acid. 
     
     
         9 . The composition of  claim 1 , wherein said composition is formulated in an enema. 
     
     
         10 . The composition of  claim 1 , wherein said composition is formulated with an antibiotic. 
     
     
         11 . The composition of  claim 1 , wherein said composition is formulated with an antiviral. 
     
     
         12 . A method for treating a patient's aerodigestive tract, the method comprising applying a composition according to  claim 1  to said aerodigestive tract. 
     
     
         13 . The method of  claim 12 , wherein said applying step comprises introducing a pharmaceutical dose to said patient. 
     
     
         14 . The method of  claim 12 , wherein said applying step comprises oral introduction of the composition of  claim 1 . 
     
     
         15 . The method of  claim 14 , wherein said oral introduction comprises a beverage comprising the composition of  claim 1 . 
     
     
         16 . The method of  claim 12 , wherein said applying step comprises intranasal presentation of a composition of  claim 1 . 
     
     
         17 . The composition of  claim 1 , wherein the acetic acid is present in an amount from about 0.25% to about 2.0% and the hypochlorous acid is present in a concentration from about 50 ppm to about 500 ppm. 
     
     
         19 . The composition of  claim 1 , wherein the hypochlorous acid is present in a concentration sufficient to modulate a toxic property of the acetic acid.

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