Algorithm for improving ovarian stimulation

Abstract

An approach is disclosed for achieving improved egg quality and simplified management in patient undergoing controlled ovarian stimulation. Information, including endogenous FSH level, is received about the patient. An optimal duration for the controlled ovarian stimulation is estimated. A target level of FSH is estimated to achieve the optimal duration. Pharmacological formulations are administered to change FSH to achieve the target level of FSH. Resulting FSH is compared to target FSH level. The amount of pharmacological formulation is adjusted when the target FSH level is not achieved; and oocyte's final maturation is triggered after achieving the optimal duration.

What is claimed is: 
     
         1 . A method for achieving improved egg quality and simplified management in patient undergoing controlled ovarian stimulation comprising:
 receiving information, including endogenous FSH level, about said patient;   estimating optimal duration for said controlled ovarian stimulation;   estimating target level of FSH in said patient to achieve said optimal duration;   prescribing a pharmacological formulation changing FSH level in circulation to achieve said target level of FSH;   measuring resulting FSH in said patient;   comparing said resulting FSH to said target level of FSH;   adjusting amount of said pharmacological formulation when said resulting FSH does not match target level of FSH; and   responsive to achieving said optimal duration, triggering oocyte's final maturation.   
     
     
         2 . A method of  claim 1 , further comprising:
 analyzing said received information to determine acceptable size of ovarian follicles at end of said ovarian stimulation;   calculating target pace of said ovarian follicle expansion to not exceed said acceptable size of said ovarian follicles at said end of said optimal duration;   estimating target level of FSH in said patient to achieve said pace of ovarian follicles expansion;   measuring said ovarian follicles after a period of time;   comparing said measured pace of follicles expansion to said target pace of expansion;   adjusting the amount of said pharmacological formulation and said target FSH level if the said pace of follicles expansion does not match said target pace of expansion;   measuring estradiol level in blood;   responsive to detecting estradiol level in blood exceeding safe level, prescribing estradiol lowering medication; and   responsive to identifying risk of premature follicle rupture, prescribing anti-inflammatory formulations to delay follicles rupture.   
     
     
         3 . The method of  claim 1 , wherein said optimal duration is about equal to duration of physiological follicular phase. 
     
     
         4 . The method of  claim 1 , wherein said target level of FSH provides said pace of ovarian follicles expansion to grow to a size of about 20 mm by said end of said optimal duration. 
     
     
         5 . The method of  claim 1 , wherein said target level of FSH recruits maximum number of follicles. 
     
     
         6 . The method of  claim 1 , wherein said cumulative level of FSH is below 25 IU/L. 
     
     
         7 . The method of  claim 1 , wherein said acceptable size of the follicles is a range. 
     
     
         8 . The method of  claims 1 , wherein said target level of FSH is a range. 
     
     
         9 . The method of  claim 1 , wherein said optimal duration is a range. 
     
     
         10 . The method of  claims 1 , wherein said pharmacological formulation contains FSH. 
     
     
         11 . The method of  claims 1 , wherein said pharmacological formulation contains hCG. 
     
     
         12 . The method of  claims 1 , wherein said pharmacological formulation contains an agent lowering FSH. 
     
     
         13 . The method of  claim 12 , wherein said agent lowering FSH is estradiol. 
     
     
         14 . The method of  claim 1 , further comprising:
 prescribing a fertilization procedure.   
     
     
         15 . The method of  claim 14 , wherein the fertilization procedure is selected from a group consisting of coitus, intrauterine insemination, and in vitro fertilization. 
     
     
         16 . The method of  claim 1 , further comprising:
 capturing said oocytes.   
     
     
         17 . The method of  claim 1 , further comprising:
 performing steps of said measuring and said adjusting iteratively until said optimal duration is reached.   
     
     
         18 . The method of  claim 1 , wherein said analyzing patient information further comprises:
 finding a plurality of best matches in a database of cases;   extracting statistical data from said plurality of best matches; and   applying said extracted statistical data as input to said analyzing.   
     
     
         19 . The method of  claim 18 , further comprising:
 capturing case studies for said achieving optimal duration of controlled ovarian stimulation for a plurality of patients P (P 1 , P 2 , . . . , Pn) undergoing assisted reproduction; and   storing said captured case studies in said database of cases.   
     
     
         20 . The method of  claim 19 , further comprising:
 training an artificial intelligence model utilizing said case studies to map said plurality of patients P (P 1 , P 2 , . . . , Pn) with corresponding demographics D (D 1 , D 2 , . . . , Dn) to a corresponding treatment plans TP (TP 1 , TP 2 , . . . , TPn) to achieve said target level of FSH;   receiving a new patient Pk with a demography Dk;   applying the trained artificial intelligence model to said new patient Dk having said demography Dk to identify said demography treatment plan TPk for said new patient Pk; and   prescribing said identified said demography treatment plan TPk to said new patient Pk.