Wound care product

Abstract

The present invention pertains to use of sodium diacetate (NaHAc2) as an antimicrobial agent against bacteria growing in biofilms. The aspects of the invention include a wound care product comprising sodium diacetate, a kit comprising a wound care product, and a method of treating an infected wound.

1 . A wound care product comprising sodium diacetate. 
     
     
         2 . A wound care product according to  claim 1 , wherein the sodium diacetate is comprised in a carrier device. 
     
     
         3 . A wound care product according to  claim 1 , wherein the sodium diacetate is in dry form. 
     
     
         4 . A wound care product according to  claim 1 , wherein the sodium diacetate is a powder. 
     
     
         5 . A wound care product according to  claim 2 , wherein the particle size of sodium diacetate is lower than 4 mm, such as lower than 2 mm, 1 mm, 0.5 mm, 0.2 mm, 0.1 mm, 0.08 mm, 0.06 mm, 0.04 mm, 0.02 mm, 0.01 mm, 0.005 mm, 0.002 mm, such as lower than 0.001 mm. 
     
     
         6 . A wound care product according to  claim 2 , wherein sodium diacetate is embedded in the carrier device in an amount in the range of 0.01- 200 mg/cm 3 , such as 0.01-100 mg/cm 3 , 0.01-75 mg/cm 3 , 0.01-50 mg/cm 3 , 0.01-40 mg/cm 3 , 0.01-30 mg/cm 3 , 0.01-20 mg/cm 3 , 0.01-10 mg/cm 3 , 0.01-5 mg/cm 3 , 0.01-2 mg/cm 3 , 0.01-1 mg/cm 3 , 0.01-0.5 mg/cm 3 , 0.01-0.4 mg/cm 3 , 0.01-0.3 mg/cm 3 , such as 0.05-5 mg/cm 3 , 0.07-5 mg/cm 3 , 0.1-5 mg/cm 3 , 0.2-5 mg/cm 3 , such as 0.3-5 mg/cm 3 . 
     
     
         7 . A wound care product according  claim 2 , wherein sodium diacetate is distributed on a surface of the carrier device in an amount in the range of 0.01-2 mg/cm 2 , such as 0.01-1 mg/cm 2 , 0.01-0.5 mg/cm 2 , 0.01-0.4 mg/cm 2 , 0.01-0.3 mg/cm 2 , such as 0.05-2 mg/cm 2 , 0.07-2 mg/cm 2 , 0.1-2 mg/cm 2 , 0.2-2 mg/cm 2 , such as 0.3-2 mg/cm 2 . 
     
     
         8 . A wound care product according to  claim 1 , wherein sodium diacetate is provided in solution. 
     
     
         9 . A wound care product according to  claim 8 , wherein the concentration of sodium diacetate is 0.10-10% (W/V), such as 0.25-5%, 0.50-5%, 0.75-5%, 1.00-5%, 1.25-5%, 1.50-5% (W/V). 
     
     
         10 . A wound care product according to  claim 1 , wherein the sodium diacetate is comprised in a carrier device selected from the group consisting of a dressing, foam, gauze, bandage, gel, or paste. 
     
     
         11 . A wound care product according to  claim 1 , wherein said product comprises sodium diacetate as the only active ingredient. 
     
     
         12 . A wound care product according to  claim 1 , wherein sodium diacetate is the only antimicrobial ingredient in said product. 
     
     
         13 . A wound care product according to  claim 1 , essentially consisting of a carrier device and sodium diacetate. 
     
     
         14 . A wound care product according to  claim 1 , wherein said product comprises at least one additional antimicrobial substance. 
     
     
         15 - 22 . (canceled) 
     
     
         23 . A method of treating a wound comprising the step of
 a) applying a wound care product according to  claim 1  to a wound.   
     
     
         24 . The method according to  claim 23 , wherein the wound is an infected wound. 
     
     
         25 . The method according to  claim 23  further comprising the steps of:
 b) applying negative pressure to the wound for 0.5-18 hours; 
 c) adjusting the pressure to ambient pressure; 
 d) removing the wound care product from the wound; and 
 e) optionally repeating steps a)-d). 
 
     
     
         26 . A kit comprising a wound care product according to  claim 1  and an adhesive membrane. 
     
     
         27 . A kit according to  claim 26  further comprising a drainage tube. 
     
     
         28 . The method according to  claim 24 , wherein the wound is a microbially infected wound. 
     
     
         29 . The method according to  claim 24 , wherein the infected wound is selected from the group consisting of a chronic wound, a wound on or around an implant, a wound on or around a prosthetic device, a wound in or around catheters, or a wound in or around the oral cavity. 
     
     
         30 . The method according to  claim 28 , wherein the microbial infection is caused by bacteria. 
     
     
         31 . The method according to  claim 30 , wherein the microbial infection is caused by bacteria selected from the group consisting of gram-negative bacteria, gram-positive bacteria, proteo bacteria, anaerobic or aerobic bacteria. 
     
     
         32 . The method according to  claim 30 , wherein the bacteria is selected from the group consisting of  P. aeruginosa, E. coli, Klebsiella pneumoniae , and  S. aureus.    
     
     
         33 . The method according to  claim 24 , wherein the infected wound is in a patient with reduced immune response. 
     
     
         34 . The method according to  claim 23 , wherein the method is used in Negative Pressure Wound Therapy.