Membrane lipid coated nanoparticles and method of use

Abstract

Disclosed is a nanoparticle comprising an inner core comprising a virus; and an outer surface comprising a cellular membrane derived from a cell, and process of making thereof. The virus is an oncolytic virus and cellular membrane is derived from for example red blood cells.

What is claimed is: 
     
         1 . A nanoparticle comprising an inner core comprising a single virus coated with an outer surface comprising a cellular membrane derived from a cell. 
     
     
         2 . The nanoparticle of  claim 1  wherein said virus is an oncolytic virus. 
     
     
         3 . The nanoparticle of  claim 1 , wherein said oncolytic virus is herpesvirus; vaccinia virus;
 reovirus; adenovirus; measles virus, parvovirus, or combinations thereof   
     
     
         4 . The nanoparticle of  claim 1  wherein said virus is adenovirus. 
     
     
         5 . The nanoparticle of  claim 1  wherein said cell is a blood cell, an adipocyte, a stem cell, an endothelial cell, an exosome, a secretory vesicle, or a synaptic vesicle. 
     
     
         6 . The nanoparticle of  claim 5  wherein said blood cell is red blood cell, white blood cell, or platelet. 
     
     
         7 . The nanoparticle of  claim 6  wherein said blood cell is red blood cell. 
     
     
         8 . A nanoparticle comprising a single virus inner core coated with an outer surface comprising a cellular membrane derived from a cell produced by combining said inner core, and said outer surface in a non-salt water solution; applying sonication to said solution to form the nanoparticle. 
     
     
         9 . The nanoparticle of  claim 8 , wherein said non-salt water solution is a sugar solution. 
     
     
         10 . The nanoparticle of  claim 9 , wherein said sugar solution is sucrose, or dextrose containing solution. 
     
     
         11 . The nanoparticle of  claim 8  wherein said virus is an oncolytic virus. 
     
     
         12 . The nanoparticle of  claim 11 , wherein said oncolytic virus is herpesvirus; vaccinia virus;
 reovirus; adenovirus; measles virus, parvovirus, or combinations thereof.   
     
     
         13 . The nanoparticle of  claim 12  wherein said virus is adenovirus. 
     
     
         14 . The nanoparticle of  claim 8  wherein said cell is a blood cell, an adipocyte, a stem cell, an endothelial cell, an exosome, a secretory vesicle, or a synaptic vesicle. 
     
     
         15 . The nanoparticle of  claim 14  wherein said blood cell is red blood cell, white blood cell, or platelet. 
     
     
         16 . The nanoparticle of  claim 15  wherein said blood cell is red blood cell.