Apparatus and method for enhancing corneal lenticular surgery with laser refractive index changes

Abstract

Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical tissues is performed in combination with corneal lenticular surgery to achieve overall desired vision corrections.

1 . A method for correcting vision in a patient comprising:
 (a) generating cut surfaces in a cornea of an eye using an apparatus comprising a first laser unit and a control unit, wherein the first laser unit focuses first pulsed laser radiation into the cornea and moves said focused radiation therein in order to generate the cut surfaces within the cornea, and wherein the control unit controls the first laser unit to generate the cut surfaces such that a predetermined lenticule to be removed in order to correct ametropia is separated from the surrounding corneal material within the cornea by at least one cut surface, and removing the predetermined lenticule from the cornea to achieve refractive corrective changes in the eye; and   (b) subsequent to step (a), modifying the refractive index of ocular tissue of the eye cornea, by injecting a multiple-photon-absorbing chromophore into a space formed by removal of the predetermined lenticule separated from the surrounding corneal material within the cornea in step (a), irradiating select regions of the ocular tissue with a focused, visible or near-IR second laser below the optical breakdown threshold of the tissue to provide refractive structures that exhibit a change in refractive index, and exhibit little or no scattering loss, and scanning over the select regions with the second laser such that ablation or removal of the tissue is not observed in the irradiated region.   
     
     
         2 . The method of  claim 1 , wherein the focused, visible or near-IR second laser has a pulse energy from 0.01 nJ to 10 nJ. 
     
     
         3 . The method of  claim 1 , wherein step (a) achieves relatively gross refractive corrective changes in the eye, and step (b) achieves further refinement corrections. 
     
     
         4 . The method of  claim 3 , further comprising performing wavefront aberrometry diagnostics between steps (a) and (b) to determine further refinements to sphere, cylinder or higher order aberrations to be corrected in step (b). 
     
     
         5 . The method of  claim 1 , wherein the first laser and the second laser are the same laser, and wherein the laser power and/or fluence is controlled separately for each of step (a) and step (b) so as to provide required performance. 
     
     
         6 . The method of  claim 1 , wherein the first laser and the second laser have different wavelengths. 
     
     
         7 . (canceled) 
     
     
         8 . The method of  claim 1 , wherein step (b) is performed to correct aberrations which were induced by step (a), or which are not correctable by step (a). 
     
     
         9 . The method of  claim 1 , wherein step (a) is performed to make monofocal refractive corrections, and step (b) is performed to write a diffractive multifocal pattern to increase the eye's depth of focus, write a refractive multifocal to increase the eye's depth of focus, or both to provide a binocular modified monovision presbyopia correction. 
     
     
         10 . (canceled) 
     
     
         11 . The method of  claim 1 , wherein the multiple-photon-absorbing chromophore comprises a two-photon-absorbing chromophore. 
     
     
         12 . The method of  claim 11 , wherein the two-photon-absorbing chromophore comprises sodium fluorescein or riboflavin. 
     
     
         13 . (canceled) 
     
     
         14 . (canceled) 
     
     
         15 . (canceled) 
     
     
         16 . The method of  claim 1 , wherein in step (b) locations defined by the focus spot are selected to form a structure selected from the group consisting of Bragg gratings, microlens arrays, zone plates, diffractive multifocals and Fresnel lenses. 
     
     
         17 . The method of  claim 1 , wherein in step (b) the laser pulses are emitted at a frequency between 1 MHz and 10 GHz. 
     
     
         18 . (canceled) 
     
     
         19 . The method of  claim 1 , wherein in step (b) the pulse width is between 10 fs and 100 fs. 
     
     
         20 . The method of  claim 1 , wherein in step (b) the laser pulses have an average power between 1 mW and 1,000 mW. 
     
     
         21 . The method of  claim 1 , wherein in step (b) the laser pulses have a pulse energy between 0.01 nJ and 10 nJ. 
     
     
         22 . (canceled) 
     
     
         23 . The method of  claim 1 , wherein in step (b) the size of the focus spot is between 0.5μ and 2μ. 
     
     
         24 . (canceled) 
     
     
         25 . (canceled) 
     
     
         26 . (canceled) 
     
     
         27 . The method of  claim 1 , wherein in step (b) the focus spot is scanned at a scanning speed of at least 1 mm/s. 
     
     
         28 . (canceled) 
     
     
         29 . The method of  claim 1 , wherein in step (b) the laser pulses have a wavelength between 600 and 1,000 nm. 
     
     
         30 . (canceled) 
     
     
         31 . The method of  claim 1 , wherein in step (b) the laser pulses have a wavelength between 1,000 and 1,300 nm. 
     
     
         32 . The method of  claim 1 , wherein in step (b) the laser pulses have a wavelength between 350 and 600 nm.