Non-hormonal steroid modulators of nf-kappa beta for treatment of disease

Abstract

The present invention relates to compounds and methods which may be useful as treatments of diseases.

1 - 10 . (canceled) 
     
     
         11 . A method to treat or reduce the symptoms of a disease chosen from uveitis, allergic bronchopulmonary aspergillosis, ankylosing spondylitis, bronchiolitis, mycosis fungoides, nephrotic syndrome, pulmonary fibrosis, sarcoidosis, and thrombocytopenia, comprising the administration, to a patient in need thereof, of a therapeutically effective amount of a compound having the structural formula: 
       
         
           
           
               
               
           
         
       
     
     
         12 . A method to treat or reduce at least one parameter of lung inflammation, comprising the administration, to a patient in need thereof, of a therapeutically effective amount of a compound having the structural formula: 
       
         
           
           
               
               
           
         
       
     
     
         13 . The method of  claim 13 , wherein the at least one parameter of lung inflammation is chosen from leukocyte infiltration (eosinophils and CD4 +  T cells) and mucus production. 
     
     
         14 . A method to treat or reduce at least one symptom of edema, comprising the administration, to a patient in need thereof, of a therapeutically effective amount of a compound having the structural formula: