Pharmaceutical compositions comprising zinc

Abstract

The present disclosure relates to pharmaceutical compositions comprising zinc, copper, at least one micronutrient, and a pharmaceutically acceptable excipient; and comprising administering, to a subject in need thereof, a pharmaceutical composition comprising zinc, copper, at least one micronutrient, and a pharmaceutically acceptable excipient.

1 - 53 . (canceled) 
     
     
         54 . A pharmaceutical composition consisting of zinc; copper; selenomethionine; at least one micronutrient chosen from the group consisting of L-ascorbic acid, pyridoxine, biotin, vitamin B12, folic acid, pantothenic acid, niacin, and vitamin E; and one or more pharmaceutically acceptable excipients; wherein the zinc is present in the pharmaceutical composition in an amount of about 45 mg to about 100 mg. 
     
     
         55 . The pharmaceutical composition according to  claim 54 , wherein the zinc is selected from zinc acetate, zinc chloride, zinc sulfate, zinc monomethionine, zinc picolinate, zinc gluconate, zinc aspartate, zinc citrate, zinc orotate, zinc glycinate, zinc oxide, and mixtures thereof. 
     
     
         56 . The pharmaceutical composition according to  claim 55 , wherein the zinc is zinc acetate. 
     
     
         57 . The pharmaceutical composition according to  claim 54 , wherein the copper is selected from copper sulfate, copper oxide, copper nitrate, copper citrate, copper glycinate, and mixtures thereof. 
     
     
         58 . The pharmaceutical composition according to  claim 57 , wherein the copper is copper sulfate. 
     
     
         59 . The pharmaceutical composition according to  claim 54 , wherein the zinc is present in an amount of about 45 mg to about 50 mg. 
     
     
         60 . The pharmaceutical composition according to  claim 54 , wherein the copper is present in an amount of about 0.5 mg to about 5 mg. 
     
     
         61 . The pharmaceutical composition according to  claim 54 , wherein the selenomethionine is present in an amount of about 25 mcg to about 200 mcg. 
     
     
         62 . The pharmaceutical composition according to  claim 54 , wherein the at least one micronutrient is a mixture of L-ascorbic acid, pyridoxine, biotin, vitamin B12, folic acid, pantothenic acid, niacin, and vitamin E. 
     
     
         63 . The pharmaceutical composition according to  claim 62 , wherein:
 L-ascorbic acid is present in an amount of about 50 mg to about 200 mg;   pyridoxine is present in an amount of about 0.5 mg to about 5 mg;   biotin is present in an amount of about 50 mcg to about 250 mcg;   vitamin B12 is present in an amount of about 50 mcg to about 250 mcg;   folic acid is present in an amount of about 100 μg to about 700 μg;   pantothenic acid is present in an amount of about 5 mg to about 15 mg;   niacin is present in an amount of about 10 mg to about 30 mg; and/or   vitamin E is present in an amount of about 5 IU to about 15 IU.   
     
     
         64 . The pharmaceutical composition according to  claim 54 , wherein the at least one micronutrient is a mixture of L-ascorbic acid and vitamin E. 
     
     
         65 . The pharmaceutical composition according to  claim 54 , wherein the one or more pharmaceutical excipients are chosen from binders, disintegrants, fillers, glidants, lubricants, preservatives, antifoaming agents, fillers, colorants, and/or plasticizers. 
     
     
         66 . The pharmaceutical composition according to  claim 54 , wherein the total weight percentage of the one or more pharmaceutical excipients in the pharmaceutical composition is up to about 35% w/w. 
     
     
         67 . The pharmaceutical composition according to  claim 54 , consisting of:
 about 45 mg to about 100 mg zinc;   about 0.5 mg to about 5 mg copper;   about 25 mcg to about 200 mcg selenomethionine;   about 50 mg to about 200 mg L-ascorbic acid;   about 0.5 mg to about 5 mg pyridoxine;   about 50 mcg to about 250 mcg biotin;   about 50 mcg to about 250 mcg vitamin B12;   about 100 μg to about 700 μg folic acid;   about 5 mg to about 15 mg pantothenic acid;   about 10 mg to about 30 mg niacin;   about 5 IU to about 15 IU vitamin E; and   one or more pharmaceutically acceptable excipients.   
     
     
         68 . The pharmaceutical composition according to  claim 54 , consisting of:
 about 50 mg zinc;   about 1.5 mg copper;   about 100 mcg selenomethionine;   about 120 mg L-ascorbic acid;   about 2 mg pyridoxine;   about 150 mcg biotin;   about 150 mcg vitamin B12;   about 400 μg folic acid;   about 10 mg pantothenic acid;   about 20 mg niacin;   about 10 IU vitamin E; and   one or more pharmaceutically acceptable excipients.   
     
     
         69 . The pharmaceutical composition according to  claim 68 , wherein the zinc is selected from zinc acetate, zinc chloride, zinc sulfate, zinc monomethionine, zinc picolinate, zinc gluconate, zinc aspartate, zinc citrate, zinc orotate, zinc glycinate, zinc oxide, and mixtures thereof. 
     
     
         70 . The pharmaceutical composition according to  claim 69 , wherein the zinc is zinc acetate. 
     
     
         71 . The pharmaceutical composition according to  claim 68 , wherein the copper is copper sulfate. 
     
     
         72 . The pharmaceutical composition according to  claim 68 , wherein the pharmaceutical composition is formulated as a powder. 
     
     
         73 . A method of producing the pharmaceutical composition according to  claim 54 , wherein the method comprises:
 blending the zinc, the copper, the selenomethionine, the at least one micronutrient, and the one or more pharmaceutically acceptable excipients into a homogeneous powder.