Biological component cassette, biological component kit, and biological component treatment system

Abstract

A biological component treatment system includes a biological component kit, and a biological component treatment device in which the biological component kit is set. The biological component kit includes tubes and a biological component cassette, the biological component cassette includes flow paths in the interior thereof, and is equipped with a cassette main body formed in a sheet shape that possesses flexibility. In the flow paths, there are provided target parameter detection parts that make it possible to detect parameters related to the culturing of cells, and the target parameter detection parts include chips that undergo coloring in response to a predetermined substance contained in a liquid. Further, the biological component treatment device includes optical sensors that detect parameters related to culturing of cells.

What is claimed is: 
     
         1 . A biological component cassette having therein a flow path through which a liquid for culturing cells is allowed to flow, and comprising a cassette main body formed in a sheet shape that possesses flexibility, wherein:
 in the flow path, there is provided a target parameter detection part through which a parameter related to culturing of cells is detectable; and   the target parameter detection part includes a chip configured to undergo coloring in response to a predetermined substance contained in the liquid.   
     
     
         2 . The biological component cassette according to  claim 1 , wherein the target parameter detection part is configured to detect, as the parameter related to culturing of cells, one parameter from among an amount of dissolved oxygen, a pH, an amount of glucose, an amount of dissolved carbon dioxide, and an amount of lactic acid. 
     
     
         3 . The biological component cassette according to  claim 1 , wherein:
 the cassette main body includes a plurality of the target parameter detection parts; and   the plurality of target parameter detection parts are configured to detect different types of parameters.   
     
     
         4 . The biological component cassette according to  claim 1 , wherein:
 the biological component cassette is connected to a bioreactor configured to culture the cells, and causes the liquid to flow out therefrom and supplies the liquid to the bioreactor, and the liquid discharged from the bioreactor flows into the biological component cassette; and   the target parameter detection part is provided in a port path, within the flow path, into which the liquid from the bioreactor flows.   
     
     
         5 . The biological component cassette according to  claim 1 , wherein the target parameter detection part includes a bulging portion that protrudes in a direction perpendicular to a planar direction of the cassette main body, the bulging portion being configured to accommodate the chip therein. 
     
     
         6 . The biological component cassette according to  claim 1 , wherein:
 the cassette main body is constituted by joining together a pair of resin sheets; and   the chip is adhered to one of the pair of resin sheets and protrudes inside the flow path in a direction perpendicular to a direction in which the flow path extends, the chip being configured as a laminated structure comprising a detection layer containing a fluorescent substance that undergoes coloring based on the predetermined substance.   
     
     
         7 . The biological component cassette according to  claim 6 , wherein a light shielding layer configured to block leakage of light is provided on a protruding end of the chip. 
     
     
         8 . The biological component cassette according to  claim 7 , wherein a light blocking coating configured to block leakage of light is provided on a side surface of the chip. 
     
     
         9 . A biological component kit comprising:
 a tube through which a liquid for culturing cells is allowed to flow; and   a biological component cassette to which the tube is connected;   wherein the biological component cassette includes therein a flow path through which the liquid is allowed to flow, and comprises a cassette main body formed in a sheet shape that possesses flexibility;   in the flow path, there is provided a target parameter detection part through which a parameter related to culturing of cells is detectable; and   the target parameter detection part includes a chip configured to undergo coloring in response to a predetermined substance contained in the liquid.   
     
     
         10 . A biological component treatment system, comprising:
 a biological component kit including a tube through which a liquid for culturing cells is allowed to flow, and a biological component cassette to which the tube is connected; and   a biological component treatment device in which the biological component kit is set;   wherein the biological component cassette includes therein a flow path through which the liquid is allowed to flow, and comprises a cassette main body formed in a sheet shape that possesses flexibility;   in the flow path, there is provided a target parameter detection part through which a parameter related to culturing of cells is detectable;   the target parameter detection part includes a chip configured to undergo coloring in response to a predetermined substance contained in the liquid; and   the biological component treatment device includes an optical sensor configured to detect the parameter related to culturing of cells, by emitting measurement light toward the chip and receiving light from the chip.   
     
     
         11 . The biological component treatment system according to  claim 10 , wherein:
 the target parameter detection part includes a bulging portion that protrudes in a direction perpendicular to a planar direction of the cassette main body, the bulging portion being configured to accommodate the chip therein; and   the biological component treatment device comprises a placement recess in which the bulging portion is arranged, and the optical sensor is disposed in a bottom part of the placement recess.