Methods of using als inhibitor herbicides for control of unwanted vegetation in als inhibitor herbicide tolerant beta vulgaris plants

Abstract

Present invention relates to the use of the ALS inhibitor herbicides for controlling unwanted vegetation in ALS inhibitor herbicide tolerant Beta vulgaris plants, more especially, present invention relates to the use of ALS inhibitor herbicides for control of unwanted vegetation in Beta vulgaris, preferably in sugar beet growing areas in which the Beta vulgaris, preferably sugar beet comprise a mutation in codon 1705-1707 of an endogenous ALS gene encoding an ALS protein containing an amino acid that is different from tryptophan at position 569, preferably the tryptophan is substituted by leucine.

1 . An ALS inhibitor herbicide capable of being used for controlling unwanted vegetation in a  Beta vulgaris  growing area in which the  Beta vulgaris  plant comprises a mutation in codon 1705-1707 of an endogenous ALS gene encoding an ALS protein containing an amino acid that is different from tryptophan at position 569. 
     
     
         2 . The ALS inhibitor herbicide according to  claim 1 , wherein the ALS inhibitor herbicide belongs to:
 the group of the (sulfon)amides (group (A)) comprising:   the subgroup (A1) of the sulfonylureas, comprising:   amidosulfuron [CAS RN 120923-37-7] (=A1-1);   azimsulfuron [CAS RN 120162-55-2] (=A1-2);   bensulfuron-methyl [CAS RN 83055-99-6] (=A1-3);   chlorimuron-ethyl [CAS RN 90982-32-4] (=A1-4);   chlorsulfuron [CAS RN 64902-72-3] (=A1-5);   cinosulfuron [CAS RN 94593-91-6] (=A1-6);   cyclosulfamuron [CAS RN 136849-15-5] (=A1-7);   ethametsulfuron-methyl [CAS RN 97780-06-8] (=A1-8);   ethoxysulfuron [CAS RN 126801-58-9] (=A1-9);   flazasulfuron [CAS RN 104040-78-0] (=A1-10);   flucetosulfuron [CAS RN 412928-75-7] (=A1-11);   flupyrsulfuron-methyl-sodium [CAS RN 144740-54-5] (=A1-12);   foramsulfuron [CAS RN 173159-57-4] (=A1-13);   halosulfuron-methyl [CAS RN 100784-20-1] (=A1-14);   imazosulfuron [CAS RN 122548-33-8] (=A1-15);   iodosulfuron-methyl-sodium [CAS RN 144550-36-7] (=A1-16);   mesosulfuron-methyl [CAS RN 208465-21-8] (=A1-17);   metsulfuron-methyl [CAS RN 74223-64-6] (=A1-18);   monosulfuron [CAS RN 55860-63-2] (=A1-19);   nicosulfuron [CAS RN 111991-09-4] (=A1-20);   orthosulfamuron [CAS RN 213464-77-8] (=A1-21);   oxasulfuron [CAS RN 144651-06-9] (=A1-22);   primisulfuron-methyl [CAS RN 86209-51-0] (=A1-23);   prosulfuron [CAS RN 94125-34-5] (=A1-24);   pyrazosulfuron-ethyl [CAS RN 93697-74-6] (=A1-25);   rimsulfuron [CAS RN 122931-48-0] (=A1-26);   sulfometuron-methyl [CAS RN 74222-97-2] (=A1-27);   sulfosulfuron [CAS RN 141776-32-1] (=A1-28);   thifensulfuron-methyl [CAS RN 79277-27-3] (=A1-29);   triasulfuron [CAS RN 82097-50-5] (=A1-30);   tribenuron-methyl [CAS RN 101200-48-0] (=A1-31);   trifloxysulfuron [CAS RN 145099-21-4] (sodium) (=A1-32);   triflusulfuron-methyl [CAS RN 126535-15-7] (=A1-33);   tritosulfuron [CAS RN 142469-14-5] (=A1-34);   NC-330 [CAS RN 104770-29-8] (=A1-35);   NC-620 [CAS RN 868680-84-6] (=A1-36);   TH-547 [CAS RN 570415-88-2] (=A1-37);   monosulfuron-methyl [CAS RN 175076-90-1] (=A1-38);   2-iodo-N-[(4-methoxy-6-methyl-1,3,5-triazinyl)carbamoyl]benzene-sulfonamide (=A1-39);   a compound of formula (I)   
       
         
           
           
               
               
           
         
         where M+denotes the respective salt of the compound (I), 
         optionally its lithium salt (=A1-40); its sodium salt (=A1-41); its potassium salt (=A1-42); its magnesium salt (=A1-43); its calcium (=A1-44); its ammonium salt (=A1-45); its methylammonium salt (=A1-46); its dimethylammonium salt (=A1-47); its tetramethylammonium salt (=A1-48); its ethylammonium salt (=A1-49); its diethylammonium salt (=A1-50); its tetraethylammonium salt (=A1-51); its propylammonium salt (=A1-52); its tetrapropylammonium salt (=A1-53); its isopropylammonium salt (=A1-54); its diisopropylammonium salt (=A1-55); its butylammonium salt (=A1-56); its tetrabutylammonium salt (=A1-57); its (2-hydroxyeth-1-yl)ammonium salt (=A1-58); its bis-N,N-(2-hydroxyeth-1-yl)ammonium salt (=A1-59); its tris-N,N,N-(2-hydroxyeth-1-yl)ammonium salt (=A1-60); its 1-phenylethylammonium salt (=A1-61); its 2-phenylethylammonium salt (=A1-62); its trimethylsulfonium salt (=A1-63); its trimethyloxonium salt (=A1-64); its pyridinium salt (=A1-65); its 2-methylpyridinium salt (=A1-66); its 4-methylpyridinium salt (=A1-67); its 2,4-dimethylpyridinium salt (=A1-68); its 2,6-dimethylpyridinium salt (=A1-69); its piperidinium salt (=A1-70); its imidazolium salt (=A1-71); its morpholinium salt (=A1-72); its 1,5-diazabicyclo[4.3.0]non-7-enium salt (=A1-73); its 1,8-diazabicyclo[5.4.0]undec-7-enium salt (=A1-74); 
         or a compound of formula (II) or salt thereof 
       
       
         
           
           
               
               
           
         
         with R 2 , and R 3  having the meaning as defined in the below table 
       
       
         
           
                 
                 
                 
                 
               
                     
                     
                 
                     
                   Compound  
                   R 2    
                   R 3   
                 
                     
                     
                 
                     
                   A1-75  
                   OCH 3    
                   OC 2 H 5    
                 
                     
                   A1-76  
                   OCH 3    
                   CH 3    
                 
                     
                   A1-77  
                   OCH 3    
                   C 2 H 5    
                 
                     
                   A1-78  
                   OCH 3    
                   CF 3    
                 
                     
                   A1-79  
                   OCH 3    
                   OCF 2 H  
                 
                     
                   A1-80  
                   OCH 3    
                   NHCH 3    
                 
                     
                   A1-81  
                   OCH 3    
                   N(CH 3 ) 2    
                 
                     
                   A1-82  
                   OCH 3    
                   Cl  
                 
                     
                   A1-83  
                   OCH 3    
                   OCH 3    
                 
                     
                   A1-84  
                   OC 2 H 5    
                   OC 2 H 5    
                 
                     
                   A1-85  
                   OC 2 H 5    
                   CH 3    
                 
                     
                   A1-86  
                   OC 2 H 5    
                   C 2 H 5   
                 
                     
                     
                 
             
                
                
                
               
               
                
                
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
         or a compound of formula (III) (=A1-87), optionally the sodium salt of compound (A1-83) 
       
       
         
           
           
               
               
           
         
         or the compound of formula (IV) (=A1-88), optionally the sodium salt of compound (A1-82) 
       
       
         
           
           
               
               
           
         
         the subgroup of the sulfonylaminocarbonyltriazolinones (subgroup ((A2)), comprising: 
         flucarbazone-sodium [CAS RN 181274-17-9] (=A2-1); 
         propoxycarbazone-sodium [CAS RN 181274-15-7] (=A2-2); 
         thiencarbazone-methyl [CAS RN 317815-83-11] (=A2-3); 
         the subgroup of the triazolopyrimidines (subgroup (A2)), comprising: cloransulam-methyl [147150-35-4] (=A3-1); 
         diclosulam [CAS RN 145701-21-9] (=A3-2); 
         florasulam [CAS RN 145701-23-1] (=A3-3); 
         flumetsulam [CAS RN 98967-40-9] (=A3-4); 
         metosulam [CAS RN 139528-85-1] (=A3-5); 
         penoxsulam [CAS RN 219714-96-2] (=A3-6); 
         pyroxsulam [CAS RN 422556-08-9] (=A3-7); 
         the subgroup of the sulfonanilides (subgroup (A4)), comprising: 
         compound or salt thereof from the group described by formula (I): 
       
       
         
           
           
               
               
           
         
         in which 
         R 1  is halogen, optionally fluorine or chlorine, 
         R 2  is hydrogen and R 3  is hydroxyl or 
         R 2  and R 3  together with the carbon atom to which they are attached are a carbonyl group C=0 and 
         R 4  is hydrogen or methyl; 
         and optionally a compound of the below given chemical structure (A4-1) to (A4-8) 
       
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         the group of the imidazolinones (group (B1)), comprising: 
         imazamethabenzmethyl [CAS RN 81405-85-8] (=B1-1); 
         imazamox [CAS RN 114311-32-9] (=B1-2); 
         imazapic [CAS RN 104098-48-8] (=B1-3); 
         imazapyr [CAS RN 81334-34-1] (=B1-4); 
         imazaquin [CAS RN 81335-37-7] (=B1-5); 
         imazethapyr [CAS RN 81335-77-5] (=B1-6); 
         SYP-298 [CAS RN 557064-77-4] (=B1-7); 
         SYP-300 [CAS RN 374718-10-2] (=B1-8) 
         the group of the pyrimidinyl(thio)benzoates (group (C)), comprising: the subgroup of the pyrimidinyloxybenzoeacids (subgroup (C1)) comprising: 
         bispyribac-sodium [CAS RN 125401-92-5] (=C1-1); 
         pyribenzoxim [CAS RN 168088-61-7] (=C1-2); 
         pyriminobac-methyl [CAS RN 136191-64-5] (=C1-3); 
         pyribambenz-isopropyl [CAS RN 420138-41-6] (=C1-4); 
         pyribambenz-propyl [CAS RN 420138-40-5] (=C1-5); and/or 
         the subgroup of the pyrimidinylthiobenzoeacids (subgroup (C2)), comprising: 
         pyriftalid [CAS RN 135186-78-6] (=C2-1); 
         pyrithiobac-sodium [CAS RN 123343-16-8] (=C2-2). 
       
     
     
         3 . The ALS inhibitor herbicide according to  claim 1 , wherein the ALS herbicide belongs to the group comprising: amidosulfuron [CAS RN 120923-37-7] (=A1-1);
 chlorimuron-ethyl [CAS RN 90982-32-4] (=A1-4);   ethametsulfuron-methyl [CAS RN 97780-06-8] (=A1-8);   ethoxysulfuron [CAS RN 126801-58-9] (=A1-9);   flupyrsulfuron-methyl-sodium [CAS RN 144740-54-5] (=A1-12); foramsulfuron [CAS RN 173159-57-4] (=A1-13);   iodosulfuron-methyl-sodium [CAS RN 144550-36-7] (=A1-16);   mesosulfuron-methyl [CAS RN 208465-21-8] (=A1-17);   metsulfuron-methyl [CAS RN 74223-64-6] (=A1-18);   monosulfuron [CAS RN 155860-63-2] (=A1-19);   nicosulfuron [CAS RN 111991-09-4] (=A1-20);   sulfosulfuron [CAS RN 141776-32-1] (=A1-28);   thifensulfuron-methyl [CAS RN 79277-27-3] (=A1-29);   tribenuron-methyl [CAS RN 101200-48-0] (=A1-31);   2-iodo-N-[(4-methoxy-6-methyl-1,3,5-triazinyl)carbamoyl]benzene-sulfonamide (=A1-39);   2-iodo-N-[(4-methoxy-6-methyl-1,3,5-triazinyl)carbamoyl]benzene-sulfonamide sodium salt (=A1-41);   (A1-83) or its sodium salt (=A1-87);   propoxycarbazone-sodium [CAS RN 181274-15-7] (=A2-2);   thiencarbazone-methyl [CAS RN 317815-83-1] (=A2-3);   florasulam [CAS RN 145701-23-1] (=A3-3);   metosulam [CAS RN 139528-85-1] (=A3-5);   pyroxsulam [CAS RN 422556-08-9] (=A3-7)   (A4-1);   (A4-2);   (A4-3);   imazamox [CAS RN 114311-32-9] (=B1-2); and/or   bispyribac-sodium [CAS RN 125401-92-5] (=C1-1).   
     
     
         4 . The ALS inhibitor herbicide according to  claim 1 , wherein the ALS inhibitor herbicide belongs to the group comprising:
 amidosulfuron [CAS RN 120923-37-7] (=A1-1);   foramsulfuron [CAS RN 173159-57-4] (=A1-13);   iodosulfuron-methyl-sodium [CAS RN 144550-36-7] (=A1-16);   2-iodo-N-[(4-methoxy-6-methyl-1,3,5-triazinyl)carbamoyl]benzene-sulfonamide (=A1-39);   2-iodo-N-[(4-methoxy-6-methyl-1,3,5-triazinyl)carbamoyl]benzene-sulfonamide sodium salt A1-41;   A1-83 or its sodium salt (=A1-87);   thiencarbazone-methyl [CAS RN 317815-83-1] (=A2-3);   imazamox [CAS RN 1 1431 1-32-9] (=B1-2) and/or   bispyribac-sodium [CAS RN 125401-92-5] (=C1-1).   
     
     
         5 . The ALS inhibitor herbicide according to  claim 1 , and wherein amino acid of the ALS protein at position 569 is leucine. 
     
     
         6 . The ALS inhibitor herbicide combination comprising said herbicide of  claim 1  with at least one non-ALS inhibitor herbicide optionally comprising at least one herbicide showing a mode of action that is different to the inhibition of the ALS enzyme [acetohydroxyacid synthase; EC 2.2.1 0.6] group D herbicides), and wherein the non-ALS inhibitor herbicide is selected form the group consisting of:
 chloridazon, clethodim, clodinafop, clodinafop-propargyl, clopyralid, cycloxydim, desmedipham, dimethenamid, dimethenamid-P, ethofumesate, fenoxaprop, fenoxaprop-P, fenoxaprop-ethyl, fenoxaprop-P-ethyl, fluazifop, fluazifop-P, fluazifop-butyl, fluazifop-P-butyl, glufosinate, glufosinate-ammonium, glufosinate-P, glufosinate-P-ammonium, glufosinate-P-sodium, glyphosate, glyphosate-isopropylammonium, haloxyfop, haloxyfop-P, haloxyfop-ethoxyethyl, haloxyfop-P-ethoxyethyl, haloxyfop-methyl, haloxyfop-P-methyl, lenacil, metamitro, phenmedipham, phenmedipham-ethyl, propaquizafop, quinmerac, quizalofop, quizalofop-ethyl, quizalofop-P, quizalofop-P-ethyl, quizalofop-P-tefuryl, and sethoxydim. 
 
     
     
         7 . The ALS inhibitor herbicide combination according to  claim 6 , and wherein the non-ALS inhibitor herbicide is selected form the group consisting of:
 desmedipham, ethofumesate, glufosinate, glufosinate-ammonium, glufosinate-P, glufosinate-P-ammonium, glufosinate-P-sodium, glyphosate, glyphosate-isopropylammonium, lenacil, metamitron, phenmedipham, and phenmedipham-ethyl.   
     
     
         8 . A method for controlling unwanted vegetation in  Beta vulgaris  plant growing areas, comprising:
 (a) having at least one  Beta vulgaris  plant comprising a mutation in codon 1705-1707 of an endogenous ALS gene encoding an ALS protein containing an amino acid that is different from tryptophan at position 569,   (b) applying one or more ALS inhibitor herbicide(s) alone or in combination with at least one herbicide that does not belong to the class of ALS inhibitor herbicides (non-ALS inhibitor herbicides), and   (c) wherein the application of the respective herbicides as defined under (b)   (i) takes place jointly or simultaneously, or   (ii) takes place at different times and/or in a plurality of portions (sequential application), in pre-emergence application followed by post-emergence application or early post-emergence application followed by medium or late post-emergence application.   
     
     
         9 . A method for controlling unwanted vegetation in  Beta vulgaris  plant growing areas, comprising using an ALS inhibitor herbicide as defined in  claim 2 . 
     
     
         10 . A method for controlling unwanted vegetation in  Beta vulgaris  plant growing areas, comprising using the ALS inhibitor herbicide as defined in  claim 3 . 
     
     
         11 . The method according to  claim 9  further comprising using a non-ALS inhibitor herbicide taken from the group comprising:
 chloridazon, clethodim, clodinafop, clodinafop-propargyl, clopyralid, cycloxydim, desmedipham, dimethenamid, dimethenamid-P, ethofumesate, fenoxaprop, fenoxaprop-P, fenoxaprop-ethyl, fenoxaprop-P-ethyl, fluazifop, fluazifop-P, fluazifop-butyl, fluazifop-P-butyl, glufosinate, glufosinate-ammonium, glufosinate-P, glufosinate-P-ammonium, glufosinate-P-sodium, glyphosate, glyphosate-isopropylammonium, haloxyfop, haloxyfop-P, haloxyfop-ethoxyethyl, haloxyfop-P-ethoxyethyl, haloxyfop-methyl, haloxyfop-P-methyl, lenacil, metamitro, phenmedipham, phenmedipham-ethyl, propaquizafop, quinmerac, quizalofop, quizalofop-ethyl, quizalofop-P, quizalofop-P-ethyl, quizalofop-P-tefuryl, and/or sethoxydim.