Microneedle system for administering liquid formulations

Abstract

The present invention relates to a microneedle system (MNS) for intradermally delivering solutions or formulations. The invention relates to a microneedle system, comprising a cover element (1), an active substance container (2), a frame (3), a microneedle array (MNA) (4) and a base plate (5), wherein the microneedle array (MNA) (4) is connected to the frame (3), and the base plate (5) has an opening for receiving the microneedle array (4), the cover element (1) and the base plate (5) are movably connected to one another, the base plate (5) is joined to a surgical tape (6), and the frame (3) and the base plate (5) can be linearly displaced with respect to one another.The MNS according to the invention is suitable for intradermally administering medicinal drugs, active substances, pharmaceutical or cosmetic compositions or other substances to an individual, and preferably to a patient, over an extended period.

1 .- 15 . (canceled) 
     
     
         16 . A microneedle system for intradermal delivery, comprising:
 i.) a cover element over an active substance container, wherein the active substance container is accommodated in a frame comprising a microneedle array; and   ii.) a base plate, wherein the base plate has an opening for receiving the microneedle array, and the cover element and the base plate are movably connected to one another via a thread;   iii.) the base plate is entirely or partially joined to a surgical tape; and   iv.) the frame and the base plate are movably connected to one another, wherein the frame comprising a microneedle array can be linearly displaced in the direction of the opening of the base plate, and the base plate comprises at least one opening element for opening the active substance container.   
     
     
         17 . The microneedle system according to  claim 16 , wherein the frame comprises one or more catch hooks, which can engage in recesses in the base plate. 
     
     
         18 . The microneedle system according to  claim 16 , wherein the base plate has a peripheral projection, including an opening, which is inwardly offset with respect to the base plate edge, and on the outer side of the edge, a thread is provided, which is complementary to the thread of the cover element. 
     
     
         19 . The microneedle system according to  claim 16 , wherein the bottom side of the cover element comprises a peripheral thread, which is complementary to the thread of the base plate. 
     
     
         20 . The microneedle system according to  claim 16 , wherein the cover element comprises one or more markings, which define how the microneedle system can be transferred from the storage position into the delivery position. 
     
     
         21 . The microneedle system according to  claim 16 , wherein the surgical tape is protected by a protective film. 
     
     
         22 . The microneedle system according to  claim 16 , wherein the diameter of the microneedle system is at least 10 mm. 
     
     
         23 . The microneedle system according to  claim 16 , wherein the diameter of the microneedle system is at least 25 mm. 
     
     
         24 . The microneedle system according to  claim 16 , wherein the diameter of the microneedle system is at least 50 mm. 
     
     
         25 . The microneedle system according to  claim 16 , wherein the height of the microneedle system is no more than 30 mm. 
     
     
         26 . The microneedle system according to  claim 16 , wherein the height of the microneedle system is no more than 20 mm. 
     
     
         27 . The microneedle system according to  claim 16 , wherein the height of the microneedle system is no more than 10 mm. 
     
     
         28 . The microneedle system according to  claim 24 , wherein the height of the microneedle system is no more than 10 mm. 
     
     
         29 . The microneedle system according to  claim 16 , wherein the active substance container is a blow-fill-seal container or a disposable container. 
     
     
         30 . The microneedle system according to  claim 16 , wherein the active substance container contains one or more substances, medicinal drugs, active agents, solutions or (liquid) formulations. 
     
     
         31 . A method for producing the microneedle system according to  claim 16 ,
 a) an active substance container being provided;   b) a microneedle array being provided; and   c) the active substance container and the microneedle array being combined with the frame, the base plate and the surgical tape to form the microneedle system, wherein the cover element and the base plate are movably connected to one another via a thread and a rotation of the cover element relative to the base plate causes the active substance container to be opened by an opening element.   
     
     
         32 . The method according to  claim 31 , wherein the active substance container being provided is produced by way of a blow-seal method. 
     
     
         33 . A method for intradermal delivery, comprising the following steps:
 a) fixing a microneedle system according to claim to the skin of the individual by way of the surgical tape; and   b) transferring the microneedle system from a storage position into the delivery position.   
     
     
         34 . The microneedle system according to  claim 16 , comprising the active substance container, containing active substances in a liquid formulation for use in the intradermal delivery.