Method and system for determining a risk of hemodynamic compromise after cardiac intervention

Abstract

A method and system for predicting a measure of hemodynamic compromise as a result of transcatheter cardiac treatment. The method includes providing a patient-specific anatomical model representing cardiac region and an implant model representing a three-dimensional representation of a cardiac implant. The method includes virtually deploying said implant model into said patient-specific anatomical model. A deformation of the patient-specific anatomical model is calculated as a result of implant model deployment A measure of hemodynamic compromise is determined from the virtually deployed implant model and the deformed patient-specific anatomical model.

1 . A computer-implemented method for pre-operative planning for delivery of a prosthetic cardiac implant to a patient's heart, the method comprising:
 obtaining a plurality of digital images of a patient's heart;   obtaining a digital three-dimensional model of a prosthetic cardiac implant;   generating, from the plurality of digital images, a digital patient-specific anatomical model representing a patient-specific cardiac region including a deployment site for the prosthetic cardiac implant;   virtually deploying the digital three-dimensional model of the prosthetic cardiac implant at the deployment site;   calculating deformation of the digital three-dimensional model of the prosthetic cardiac implant, in the deployed state, within the deployment site of the patient-specific cardiac region; and   determining a measure of interaction between the digital three-dimensional model of the prosthetic cardiac implant and the patient-specific cardiac region of the digital patient-specific anatomical model.   
     
     
         2 . The computer-based method of  claim 1 , wherein determining a measure of interaction comprises determining a blood flow path associated with the digital three-dimensional model of the prosthetic cardiac implant and the patient-specific cardiac region of the digital patient-specific anatomical model. 
     
     
         3 . The computer-based method of  claim 1 , wherein determining a measure of interaction comprises determining a measure of leakage in or around a perimeter of the digital three-dimensional model of the prosthetic cardiac implant. 
     
     
         4 . The computer-based method of  claim 1 , further comprising providing the patient-specific digital anatomical model of the patient-specific cardiac region at a plurality of moments during a cardiac cycle, and wherein the measure of interaction is determined at the plurality of moments. 
     
     
         5 . The computer-based method of  claim 1 , further comprising determining the measure of interaction after simulating remodeling of the patient-specific digital anatomical model of the patient-specific cardiac region caused by prolonged presence of the digital three-dimensional model of the prosthetic cardiac implant. 
     
     
         6 . The computer-based method of  claim 1 , wherein determining the measure of interaction comprises determining a degree of incomplete deployment of the digital three-dimensional model of the prosthetic cardiac implant. 
     
     
         7 . The computer-based method of  claim 1 , wherein the digital three-dimensional model of the prosthetic cardiac implant is a digital three-dimensional model of a prosthetic heart valve. 
     
     
         8 . The computer-based method of  claim 1 , wherein the digital three-dimensional model of the prosthetic cardiac implant is a digital three-dimensional model of a left atrial appendage closure device. 
     
     
         9 . The computer-based method of  claim 1 , wherein determining the measure of interaction comprises determining a measure of hemodynamic compromise associated with deploying the digital three-dimensional model of the prosthetic cardiac implant at the deployment site. 
     
     
         10 . The computer-based method of  claim 1 , wherein the digital three-dimensional model of the prosthetic cardiac implant is selected to block clots from going into a bloodstream. 
     
     
         11 . The computer-based method of  claim 1 , further comprising virtually deploying the digital three-dimensional model of the prosthetic cardiac implant into the patient-specific digital anatomical model of the cardiac region at a plurality of different locations and determining the measure of interaction for each of the plurality of different locations. 
     
     
         12 . The computer-based method of  claim 1 , wherein virtually deploying the digital three-dimensional model of the prosthetic cardiac implant further comprises:
 providing a plurality of digital three-dimensional models of prosthetic cardiac implants having different geometrical or material properties; and   virtually deploying each of the plurality of digital three-dimensional models of prosthetic cardiac implants into the patient specific digital anatomical model of the patient's cardiac region, and   determining the measure of interaction for each of the plurality of digital three-dimensional models of prosthetic cardiac implants.   
     
     
         13 . The computer-based method of  claim 12 , further comprising determining a corresponding one of the plurality of digital three-dimensional models of prosthetic cardiac implants that causes a preferred degree of interaction as compared to others of the plurality of digital three-dimensional models of prosthetic cardiac implants. 
     
     
         14 . The computer-based method of  claim 1 , further comprising displaying the measure of interaction on a computer system display and the digital three-dimensional model of the prosthetic cardiac implant deployed at the deployment site. 
     
     
         15 . A system for pre-operative planning for delivery of a prosthetic cardiac implant to a patient's heart, the system comprising at least one processor configured to:
 obtain a plurality of digital images of a patient's heart;   obtain a digital three-dimensional model of a prosthetic cardiac implant;   generate, from the plurality of digital images, a digital patient-specific anatomical model representing a patient-specific cardiac region including a deployment site for the prosthetic cardiac implant;   virtually deploy the digital three-dimensional model of the prosthetic cardiac implant at the deployment site;   calculate deformation of the digital three-dimensional model of the prosthetic cardiac implant, in the deployed state, within the deployment site of the patient-specific cardiac region; and   determine a measure of interaction between the digital three-dimensional model of the prosthetic cardiac implant and the patient-specific cardiac region of the digital patient-specific anatomical model.   
     
     
         16 . The system of  claim 15 , wherein the digital three-dimensional model of the prosthetic cardiac implant is a digital three-dimensional model of a prosthetic heart valve. 
     
     
         17 . The system of  claim 15 , wherein the digital three-dimensional model of the prosthetic cardiac implant is a digital three-dimensional model of a left atrial appendage closure device. 
     
     
         18 . The system of  claim 15 , wherein the system is further configured to virtually deploy the digital three-dimensional model of the prosthetic cardiac implant into the patient-specific digital anatomical model of the cardiac region at a plurality of different locations and determine the measure of interaction for each of the plurality of different locations. 
     
     
         19 . The system of  claim 15 , wherein the virtually deployment of the digital three-dimensional model of the prosthetic cardiac implant further comprises:
 provide a plurality of digital three-dimensional models of prosthetic cardiac implants having different geometrical or material properties; and   virtually deploy each of the plurality of digital three-dimensional models of prosthetic cardiac implants into the patient specific digital anatomical model of the patient's cardiac region, and   determine the measure of interaction for each of the plurality of digital three-dimensional models of prosthetic cardiac implants.   
     
     
         20 . The system of  claim 19 , wherein the system is further configured to determine a corresponding one of the plurality of digital three-dimensional models of prosthetic cardiac implants that causes a preferred degree of interaction as compared to others of the plurality of digital three-dimensional models of prosthetic cardiac implants. 
     
     
         21 . A non-transitory computer-readable medium storing computer implementable instructions that when executed by a programmable computer cause the computer to:
 obtain a plurality of digital images of a patient's heart;   obtain a digital three-dimensional model of a prosthetic cardiac implant;   generate, from the plurality of digital images, a digital patient-specific anatomical model representing a patient-specific cardiac region including a deployment site for the prosthetic cardiac implant;   virtually deploy the digital three-dimensional model of the prosthetic cardiac implant at the deployment site;   calculate deformation of the digital three-dimensional model of the prosthetic cardiac implant, in the deployed state, within the deployment site of the patient-specific cardiac region; and   determine a measure of interaction between the digital three-dimensional model of the prosthetic cardiac implant and the patient-specific cardiac region of the digital patient-specific anatomical model.