Probiotic compositions and uses thereof

Abstract

The present invention relates to an isolated bacterial strain of Lactiplantibacillus plantarum subsp. plantarum MFM 30-3 deposited at Food Industry Research and Development Institute, Taiwan, under accession number BCRC 911035. The present invention also relates to a probiotic composition comprising an isolated bacterial strain of Lactiplantibacillus plantarum subsp. plantarum MFM 30-3 deposited at Food Industry Research and Development Institute, Taiwan, under accession number BCRC 911035, and optionally, one or more additional probiotic organisms that enhance the probiotic activity of the Lactiplantibacillus plantarum subsp. plantarum MFM 30-3. The present invention further relates to a method for preventing or treating chronic kidney disease in a subject in need thereof comprising: administering to said subject a pharmaceutically effective amount of the probiotic composition comprising an isolated bacterial strain of Lactiplantibacillus plantarum subsp. plantarum MFM 30-3 deposited at Food Industry Research and Development Institute, Taiwan, under accession number BCRC 911035, and optionally, one or more additional probiotic organisms that enhance the probiotic activity of the Lactiplantibacillus plantarum subsp. plantarum MFM 30-3.

1 . An isolated bacterial strain of  Lactiplantibacillus plantarum  subsp.  plantarum MFM  30-3 deposited under the DSMZ Accession No. DSM 34213. 
     
     
         2 . A probiotic composition comprising an isolated bacterial strain of  Lactiplantibacillus plantarum  subsp.  plantarum  MFM 30-3 deposited under the DSMZ Accession No. DSM 34213, and optionally, one or more additional probiotic organisms that enhance the probiotic activity of the  Lactiplantibacillus plantarum  subsp.  plantarum MFM  30-3. 
     
     
         3 . The probiotic composition of  claim 2 , which comprises an isolated bacterial strain of  Lactiplantibacillus plantarum  subsp.  plantarum MFM  30-3 deposited under the DSMZ Accession No. DSM 34213, and an isolated bacterial strain of  Lacticaseibacillus paracasei  subsp.  paracasei  MFM 18 deposited under the DSMZ Accession No. DSM 34212. . 
     
     
         4 . The probiotic composition of  claim 2 , wherein the composition is in solid, liquid or semisolid form. 
     
     
         5 . The probiotic composition of  claim 2 , wherein the composition is a food, a food supplement, a nutraceutical, or a therapeutic. 
     
     
         6 . A method for preventing or treating chronic kidney disease in a subject in need thereof comprising: administering to said subject a pharmaceutically effective amount of the composition of  claim 2 . 
     
     
         7 . The method of  claim 6 , wherein the composition comprises an isolated bacterial strain of  Lactiplantibacillus plantarum  subsp.  plantarum  MFM 30-3 deposited under the DSMZ Accession No. DSM 34213, and an isolated bacterial strain of  Lacticaseibacillus paracasei  subsp.  paracasei  MFM 18 deposited under the DSMZ Accession No. DSM 34212. 
     
     
         8 . The method of  claim 6 , which reduces the content of the indicative molecule selected from indole, p-cresol, indoxyl sulfate, or p-cresyl sulfate. 
     
     
         9 . The method of  claim 6 , which reverses gut dysbiosis and restores the abundance of commensal bacteria. 
     
     
         10 . The method of  claim 6 , which improves intestinal barrier integrity.