Use of tradipitant in motion sickness

Abstract

Disclosed herein is a method of treating or preventing motion sickness or at least one symptom thereof, comprising treatment with the NK-1 receptor antagonist, tradipitant.

We claim: 
     
         1 . A method of treating a subject about to engage in an activity involving sickness-inducing motion comprising:
 administering tradipitant to said subject, prior to the commencement of said activity, in an amount effective to prevent motion sickness or at least one symptom of motion sickness in said subject.   
     
     
         2 . The method of  claim 1 , wherein said activity is vehicle travel. 
     
     
         3 . The method of  claim 2 , wherein said administration occurs about 30 minutes prior to entering a vehicle. 
     
     
         4 . The method of  claim 2 , wherein said administration occurs about 30 minutes prior to commencement of vehicle travel. 
     
     
         5 . The method of  claim 1 , wherein said effective amount is 100-400 mg. 
     
     
         6 . The method of  claim 5 , wherein said effective amount is 100-300 mg. 
     
     
         7 . The method of  claim 6 , wherein said effective amount is 100-200 mg. 
     
     
         8 . The method of  claim 7 , wherein said effective amount is about 170 mg. 
     
     
         9 . The method of  claim 1 , further comprising orally administering said effective amount of tradipitant. 
     
     
         10 . The method of  claim 9 , wherein said tradipitant is orally administered in a solid immediate release form such as a capsule or tablet comprising tradipitant and one or more pharmaceutically acceptable excipients. 
     
     
         11 . The method of  claim 2 , wherein said vehicle travel is via automobile, airplane, helicopter, boat, train, or bus. 
     
     
         12 . The method of  claim 1 , wherein said at least one symptom is nausea, vomiting, dizziness, headache, fullness, or disorientation. 
     
     
         13 . A method of treating a subject with motion sickness or at least one symptom of motion sickness, comprising:
 administering tradipitant to said subject in an amount effective to treat said sickness or a symptom thereof.   
     
     
         14 . The method of  claim 13 , wherein said effective amount is 100-400 mg. 
     
     
         15 . The method of  claim 14 , wherein said effective amount is 100-300 mg. 
     
     
         16 . The method of  claim 15 , wherein said effective amount is 100-200 mg. 
     
     
         17 . The method of  claim 16 , wherein said effective amount is about 170 mg. 
     
     
         18 . The method of  claim 13 , wherein said administration further comprises oral administration of tradipitant. 
     
     
         19 . The method of  claim 18 , wherein said tradipitant is orally administered in a solid immediate release form such as a capsule or tablet comprising tradipitant and one or more pharmaceutically acceptable excipients. 
     
     
         20 . The method of  claim 13 , wherein said at least one symptom is nausea, vomiting, dizziness, headache, fullness, or disorientation.