Biodegradable polymer fine particle for filler, freeze-dried body including the same, manufacturing method thereof, and filler injection including freeze-dried body

Abstract

Disclosed herein are a biodegradable polymer microparticle for a filler, a freeze-dried body including the same, a manufacturing method thereof, and filler injection including the freeze-dried body. The freeze-dried body includes hydrophilic surface-treated biodegradable polymer microparticle and a biocompatible carrier, wherein the hydrophilic surface-treated biodegradable polymer microparticle has an average particle diameter (D50) of 20 to 50 μm and is polydioxanone which has a carboxyl group on the surface thereof. The hydrophilic surface-treated biodegradable polymer microparticle is a plasma surface-treated product or a base surface-treated product using discharge of the biodegradable polymer microparticle. The content of the biocompatible carrier is 1 to 5 parts by weight based on 100 parts by weight of the freeze-dried body.

1 . A freeze-dried body for a filler comprising hydrophilic surface-treated biodegradable polymer microparticle and a biocompatible carrier, wherein the hydrophilic surface-treated biodegradable polymer microparticle has an average particle diameter (D 50 ) of 20 to 50 μm and is polydioxanone which has a carboxyl group on the surface thereof,
 wherein the hydrophilic surface-treated biodegradable polymer microparticle is a plasma surface-treated product or a base surface-treated product using discharge of the biodegradable polymer microparticle, 
 wherein the content of the biocompatible carrier is 1 to 5 parts by weight based on 100 parts by weight of the freeze-dried body, 
 wherein the biocompatible carrier is sodium carboxymethyl cellulose, and the moisture content in the freeze-dried body is 0.5 to 1.0% by weight, 
 wherein a powder-water contact angle value to the hydrophilic surface-treated biodegradable polymer microparticle is 35.1 to 35.7°, 
 wherein the base surface-treated product of the biodegradable polymer microparticle is a product obtained through the operations of: adding 0.1 to 5% by weight of a sodium hydroxide solution to the biodegradable polymer microparticle for a filler, and stirring it for 30 seconds to 300 seconds; and washing and vacuum-drying the product obtained through the stirring operation, wherein the content of sodium hydroxide is 1 to 5 parts by weight based on 100 parts by weight of the biodegradable polymer microparticle for a filler, and 
 wherein the plasma surface-treated product is a product obtained through the operations of: applying voltage to the biodegradable polymer microparticle for a filler to induce discharge; and performing a discharge treatment of the biodegradable polymer microparticle, wherein the discharge treatment of the biodegradable polymer microparticle is performed through the operations of: injecting 400 to 600 mL/min of air in a plasma reaction device; applying 300 Hz to 500 Hz of alternating current to an electrode to which a power supply unit is connected to obtain plasma-treated air; and making the plasma-treated air come into contact with the biodegradable polymer microparticle. 
 
     
     
         2 . The freeze-dried body according to  claim 1 , wherein the particle diameter (D 10 ) of the surface-treated biodegradable polymer microparticle is 10 to 20 μm, and the particle diameter (D 90 ) of the surface-treated biodegradable polymer microparticle is 60 to 70 μm. 
     
     
         3 . The freeze-dried body according to  claim 1 , wherein the number average molecular weight (Mn) of the biodegradable polymer microparticle is 50,000 to 500,000 Daltons. 
     
     
         4 . The freeze-dried body according to  claim 1 , wherein the biodegradable polymer microparticle is manufactured through the operations of: providing a first composition containing organic solvent miscible with water, and biodegradable polymer microparticles; providing a second composition containing surfactant and water; preparing mixture by mixing the first composition and the second composition; stirring the mixture to prepare a third composition containing polymer microparticles; separating the polymer microparticles from the third composition; and sorting polymer microparticles, of which the average particle diameter is 20 to 50 μm, from the separated polymer microparticles. 
     
     
         5 . A filler injection comprising:
 a freeze-dried body according to  claim 1 ; and   one or more selected from injection water, sterilized water, and distilled water.   
     
     
         6 . The filler injection according to  claim 5 , wherein the filler injection is obtained through dispersing 1 g of freeze-dried body in 10 ml of one or more selected from injection water, sterilized water, and distilled water, and performing precipitation of the biodegradable polymer microparticle for a filler after 60 minutes. 
     
     
         7 . The filler injection according to  claim 5 , wherein the content of the freeze-dried body is 1 to 10 parts by weight based on the total weight of the filler injection. 
     
     
         8 . The filler injection according to  claim 5 , wherein viscosity of the filler injection is 50 to 2000 cP. 
     
     
         9 . A manufacturing method of a freeze-dried body for a filler according to  claim 1 , the manufacturing method comprising the operations of:
 preparing a biodegradable polymer microparticle for a filler having an average particle diameter of 20-50 μm;   surface-treating the biodegradable polymer microparticle with plasma or base to manufacture a surface-treated biodegradable polymer microparticle;   dissolving the hydrophilic surface-treated biodegradable polymer microparticle, the biocompatible carrier, and distilled water to obtain a mixed solution; and   freeze-drying the mixed solution to obtain a freeze-dried body,   wherein the operation of surface-treating with plasma using discharge is performed through injecting 400 to 600 mL/min of air in a plasma reaction device, applying 300 Hz to 500 Hz of alternating current to an electrode to which a power supply unit is connected so that plasma-treated air comes into contact with the biodegradable polymer microparticle, and   wherein the operation of surface-treating with base is performed through adding and treating the biodegradable polymer microparticle to 0.1 to 5% by weight of a sodium hydroxide solution to obtain microparticles, and washing and vacuum-drying the microparticles, wherein the content of sodium hydroxide is 0.1 to 5 parts by weight based on 100 parts by weight of the biodegradable polymer microparticles.   
     
     
         10 . The manufacturing method according to  claim 9 , wherein the biodegradable polymer microparticle is manufactured through the operations of: providing a first composition containing organic solvent miscible with water, and biodegradable polymer microparticles; providing a second composition containing surfactant and water; preparing mixture by mixing the first composition and the second composition; stirring the mixture to prepare a third composition containing polymer microparticles; separating the polymer microparticles from the third composition; and sorting polymer microparticles, of which the average particle diameter is 20 to 50 μm, from the separated polymer microparticles.