Dp antagonist

Abstract

An object of the present invention is to provide a DP receptor antagonist. A compound represented by general formula (I):(wherein all symbols are as shown in the specification) and a pharmaceutically acceptable salt thereof have DP receptor antagonistic activity and are also highly safe, and thus are useful as active ingredients of pharmaceuticals for DP receptor-mediated diseases. In addition, the compound represented by the general formula (I) and the pharmaceutically acceptable salt thereof also have good transferability to the central nervous system, and thus are particularly useful as a preventive and/or therapeutic agent for diseases associated with DP receptors present in the central nervous system among DP receptor-mediated diseases, that is, sleep-wake disorders.

1 . A method for treating a DP receptor-mediated disease, comprising administering an effective amount of a compound that is {4-Chloro-3-[(2,6-dimethyl-4-{2-[(2R)-oxan-2-yl]ethoxy}benzene-1-carbothioyl)amino]phenyl}acetic acid or a pharmaceutically acceptable salt thereof to a patient in need of prevention and/or treatment of the DP receptor-mediated disease. 
     
     
         2 . The method according to  claim 1 , wherein {4-Chloro-3-[(2,6-dimethyl-4-{2-[(2R)-oxan-2-yl]ethoxy}benzene-1-carbothioyl)amino]phenyl}acetic acid is administered. 
     
     
         3 . The method according to  claim 1 , wherein a pharmaceutically acceptable salt of {4-Chloro-3-[(2,6-dimethyl-4-{2-[(2R)-oxan-2-yl]ethoxy}benzene-1-carbothioyl)amino]phenyl}acetic acid is administered. 
     
     
         4 . The method according to  claim 1 , wherein the DP receptor-mediated disease is allergic disease, systemic mastocytosis, systemic mast cell activation disorder, anaphylactic shock, respiratory tract constriction, urticaria, eczema, acne, allergic bronchopulmonary aspergillosis, sinusitis, migraine, nasal polyps, hypersensitivity vasculitis, eosinophilia, contact dermatitis, a disease accompanied by itching, a disease caused secondarily as a result of behavior accompanied by itching, a disease accompanied by flushing, inflammation, chronic obstructive pulmonary disease, ischemia-reperfusion injury, cerebrovascular accident, autoimmune disease, cerebral trauma, liver disorder, graft rejection, rheumatoid arthritis, pleurisy, osteoarthritis, Crohn's disease, ulcerative colitis, irritable bowel syndrome, interstitial cystitis, muscular dystrophy, polymyositis, cancer, leukemia, viral infection, multiple sclerosis, sleep-wake disorder, or platelet aggregation. 
     
     
         5 . The method according to  claim 4 , wherein DP receptor-mediated disease is sleep-wake disorder, and the sleep-wake disorder is a disease comprises hypersomnia, insomnia, residual sleepiness of sleep apnea syndrome, circadian rhythm sleep-wake disorder, hypersomnia associated with neurodegenerative disease, hypersomnia associated with mental illness, or morbid sleep apnea during daytime.