Multiple Dosage Injector with Rotating Screw Dosage System

Abstract

A dispensing mechanism for delivering a dosage of medicament including a housing having a proximal-distal axis; a plunger rod having a screw thread and configured to advance along the proximal-distal axis relative to the housing; a user-operable push button moveable along the proximal-distal axis relative to the housing; a twist driver threadably engaged with the push button such that movement of the push button towards the distal end of the housing causes rotation of the twist driver about the proximal-distal axis; and a driver engaged with the twist driver such that rotation of the twist driver causes rotation of the driver, the driver also engaged with a portion of the plunger rod such that rotation of the driver causes rotation of the plunger rod, advancing the plunger rod along the proximal-distal axis relative to the housing.

1 . A dispensing mechanism, comprising:
 a housing having a proximal-distal axis;   a plunger rod having a screw thread and configured to advance along the proximal-distal axis relative to the housing;   a user-operable push button moveable along the proximal-distal axis relative to the housing;   a twist driver threadably engaged with the push button such that movement of the push button towards the distal end of the housing causes rotation of the twist driver about the proximal-distal axis; and   a driver engaged with the twist driver such that rotation of the twist driver causes rotation of the driver, the driver also engaged with a portion of the plunger rod such that rotation of the driver causes rotation of the plunger rod, advancing the plunger rod along the proximal-distal axis relative to the housing.   
     
     
         2 . An injector comprising:
 the dispensing mechanism of  claim 1 ,   a cartridge disposed within the housing;   a plunger disposed in the cartridge to seal a medicament therein, wherein the plunger rod is associated with the plunger for forcing the plunger in a distal direction for ejecting a dose of medicament; and   a needle in fluid communication with the cartridge for injecting the doses into a patient.   
     
     
         3 . The injector of  claim 2 , wherein the medicament includes a parathyroid hormone. 
     
     
         4 . The injector of  claim 3 , wherein the parathyroid hormone is teriparatide. 
     
     
         5 . The dispensing mechanism of  claim 1 , further comprising:
 an anti-reverse mechanism including:
 at least one ratchet integrally formed on an internal surface of the housing; and 
 a flexible column integrally formed within a side opening of the push button, the flexible column having a flexible column protrusion at a proximal end thereof, 
   wherein as the push button moves along the proximal-distal axis, the flexible column protrusion engages the ratchet and restricts movement of the push button to one direction during a firing motion and a resetting motion.   
     
     
         6 . The dispensing mechanism of  claim 5 , wherein the flexible column protrusion is generally elliptically shaped. 
     
     
         7 . The dispensing mechanism of  claim 1 , further comprising:
 a nut fixated within the housing having protrusions on an internal surface that engage the screw thread of plunger rod such that as the plunger rod rotates, the plunger rod is advanced along the proximal-distal axis relative to the housing.   
     
     
         8 . The dispensing mechanism of  claim 1 , wherein the twist driver further includes a ratchet flap that is configured to engage a lip of the driver such that the twist driver can axially rotate about the proximal-distal axis in generally only one direction. 
     
     
         9 . The dispensing mechanism of  claim 1 , further comprising a biasing member disposed within push button to facilitate movement of the push button from a fired position to a reset position.