Packaging and devices for mixing medicament substances

Abstract

A device (200) for mixing first and second substances. The device comprises a first container (100) for storage of the first substance and a second container (150) received in the first container (100) and for storage of the second substance. An outlet (112) is disposed at the distal end of the first container (100). Valve means (180) are provided for closing a distal end of the second container (150) and a proximal end of the first container (100). A stopper means (166) closes a proximal end of the second chamber (152) and is movable with respect to the second container (150). An operating mechanism drives relative movement between the first and second containers for causing displacement of the second substance into the first chamber (102) through the valve means (180) when the outlet (112) is closed, for mixing the first and second substances in a mixing stroke of the device.

1 - 36 . (canceled) 
     
     
         37 . A cartridge for packaging medicament substances for use with a delivery device or an adaptor for a delivery device, the cartridge comprising:
 a first container having a first chamber for storage of a first substance and an outlet disposed at a distal end of the first chamber;   a sealing element for closing the outlet;   a second container arranged coaxially with respect to the first container and having a second chamber for storage of a second substance;   a valve for closing a distal end of the second chamber; and   a stopper means for closing a proximal end of the second chamber, the stopper being movable with respect to the second container;   wherein the second container is at least partially received in the first container to close a proximal end of the first chamber when the valve is closed;   wherein the second container is movable in a proximal direction with respect to the first container to open the valve and to displace the second substance into the first chamber through the valve when the outlet is closed, thereby to cause mixing of the first and second substances; and   wherein the second container is movable in a distal direction with respect to the first container to close the valve and to displace the mixed first and second substances through the outlet when the outlet is open.   
     
     
         38 . The cartridge according to  claim 37 , further comprising an inner closure member disposed at a distal end of the second container, wherein the inner closure member comprises the valve. 
     
     
         39 . The cartridge according to  claim 38 , wherein the inner closure member provides a seal between the second container and the first container. 
     
     
         40 . The cartridge according to  claim 38 , wherein the closure member is elastomeric. 
     
     
         41 . The cartridge according to  claim 37 , wherein the valve comprises a one-way valve. 
     
     
         42 . The cartridge according to  claim 41 , wherein the valve comprises a slit valve. 
     
     
         43 . The cartridge according to  claim 37 , wherein the sealing element comprises a pierceable septum. 
     
     
         44 . The cartridge according to  claim 37 , further comprising an outer closure member disposed at a distal end of the first container, and wherein the outer closure member comprises the sealing element. 
     
     
         45 . The cartridge according to  claim 37 , further comprising a coupling element disposed at a distal end of the first container, wherein the coupling element is arranged for coupling the cartridge to the delivery device or adaptor. 
     
     
         46 . The cartridge according to  claim 45 , wherein the coupling element retains the sealing element. 
     
     
         47 . The cartridge according to  claim 45 , wherein the coupling element is arranged to couple the cartridge to the delivery device or adaptor in a first attachment position in which the outlet is closed and a second attachment position in which the sealing element is released by a sealing element release member of the delivery device or adaptor to open the outlet. 
     
     
         48 . The cartridge according to  claim 45 , wherein the coupling element comprises an engagement formation for cooperation with an engagement part of the delivery device or adaptor to clip the cartridge to the delivery device or adaptor upon insertion of the cartridge. 
     
     
         49 . The cartridge according to  claim 37 , further comprising a seal arrangement for sealing a proximal end of a sealing element release member of the delivery device or the adaptor in an enclosed chamber adjacent the sealing element before release of the sealing element to open the outlet. 
     
     
         50 . The cartridge according to  claim 49 , wherein the seal arrangement is disposed distally with respect to the sealing element and is arranged to form a seal around the release member when the cartridge is coupled to the delivery device or adaptor. 
     
     
         51 . The cartridge according to  claim 50 , wherein the seal arrangement comprises a bore for receiving the release member. 
     
     
         52 - 62 . (canceled)