US2022185860A1PendingUtilityA1
Cell surface coupling of nanoparticles
Assignee: MASSACHUSETTS INSTITUTE OF TECH MITN1Priority: Aug 12, 2015Filed: Feb 28, 2022Published: Jun 16, 2022
Est. expiryAug 12, 2035(~9 yrs left)· nominal 20-yr term from priority
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Claims
Abstract
The present disclosure is directed, in some embodiments, to methods and compositions of comprising a cell having a non-internalizing receptor, and a nanoparticle surface-modified with a ligand that binds to the non-internalizing receptor.
Claims
exact text as granted — not AI-modified1 . A method of treating cancer in a subject comprising administering a composition to the subject, wherein the composition comprises: a carrier cell that includes a cytokine receptor on its surface; and a protein nanogel that includes cytokines that interact with the cytokine receptor and are linked to each other via a linker.
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