Functionalized prosthetic interfaces for the prevention and treatment of dental conditions

Abstract

Provided are compositions and devices containing microspheres encapsulating one or more drug(s). The compositions and devices may be used to treat or prevent infection associated or caused by oral mucosal diseases, oral infections, oral conditions, dental conditions, or surgical recovery. The devices include, but are not limited to, splints, mouth guards, full dentures, partial dentures, or fillings. The devices may be manufactured from filaments that have a composition of the present disclosure. Also provided are methods of making and using the devices and compositions.

What is claimed is: 
     
         1 . A device, comprising:
 (a) a prosthesis; and   (b) one or more microsphere(s) encapsulating one or more drug(s),   
       wherein the one or more microsphere(s) are disposed in the prosthesis and/or on a surface of the prosthesis. 
     
     
         2 . The device of  claim 1 , wherein the prosthesis is chosen from a splint, mouth guard, full denture, partial denture, or filling. 
     
     
         3 . The device of  claim 1 , wherein the one or more microsphere(s) comprise polycaprolactone (PCL), polylactic acid, chitosan, polyethylene, glass, polyphosphazene, or polymethacrylate. 
     
     
         4 . The device of  claim 1 , wherein the one or more microsphere(s) is/are PCL. 
     
     
         5 . The device of  claim 1 , wherein the one or more drug(s) are the same or different. 
     
     
         6 . The device of  claim 1 , wherein the one or more drug(s) are chosen from antimicrobial agent(s), antifungal agent(s), antibiotic(s), antiviral(s), analgesic(s), steroid(s), immune modulator(s), fluoride, and combinations thereof. 
     
     
         7 . The device of  claim 6 , wherein the one or more drug(s) is an antifungal agent chosen from amphotericin B, flucytosine, fluconazole, ketoconazole, miconazole, terbinafine, griseofulvin, Clotrimazole, Econazole, Anidulafungin, Micafungin, Caspofungin, Butoconazole. Bifonazole, Clotrimazole, Econazole. Fenticonazole, Isoconazole, Ketoconazole, Luliconazole, Miconazole, Omoconazole, Oxiconazole, Sulconazole, Sertaconazole, Tioconazole, Albaconazole, Abafungin, amorolfin, butenafine, naftifine, terbinafine, Epoxiconazole, Efinaconazole, Fluconazole, Itraconazole, Isavuconazole, Propiconazole, Posaconazole, Ravuconazole, Terconazole, Voriconazole, and the like, and combinations thereof. 
     
     
         8 . The device of  claim 7 , wherein the antifungal agent is amphotericin B. 
     
     
         9 . The device of  claim 1 , wherein the prosthesis comprises polymethylmethacrylate (PMMA). 
     
     
         10 . The device of  claim 1 , wherein the prosthesis is 3D printed. 
     
     
         11 . A method of making a device comprising:
 (a) obtaining a scan, mold, or model of an individual's oral cavity where the dental prosthesis will fit;   (b) fabricating a core dental prosthesis corresponding to the individual's scan, mold, or model of the oral cavity with PMMA polymer;   (c) generating one or more microsphere(s)comprising one or more drug(s); and   (d) coating the core dental prosthesis with the one or more microsphere(s)comprising one or more drug(s).   
     
     
         12 . The method of  claim 11 , wherein the prosthesis is a denture. 
     
     
         13 . The method of  claim 11 , wherein the one or more drug(s) are chosen from antimicrobial agent(s), antifungal agent(s), antibiotic(s), antiviral(s), analgesic(s), steroid(s), immune modulator(s), fluoride, and combinations thereof. 
     
     
         14 . The method of  claim 13 , wherein the one or more drug(s) is an antifungal agent chosen from amphotericin B, flucytosine, fluconazole, ketoconazole, miconazole, terbinafine, griseofulvin, Clotrimazole, Econazole, Anidulafungin, Micafungin, Caspofungin, Butoconazole. Bifonazole, Clotrimazole, Econazole. Fenticonazole, Isoconazole, Ketoconazole, Luliconazole, Miconazole, Omoconazole, Oxiconazole, Sulconazole, Sertaconazole, Tioconazole, Albaconazole, Abafungin, amorolfin, butenafine, naftifine, terbinafine, Epoxiconazole, Efinaconazole, Fluconazole, Itraconazole, Isavuconazole, Propiconazole, Posaconazole, Ravuconazole, Terconazole, Voriconazole, and the like, and combinations thereof. 
     
     
         15 . The method of  claim 14 , wherein the antifungal agent is amphotericin B. 
     
     
         16 . The method of  claim 11 , wherein the one or more microsphere(s) comprise PCL. 
     
     
         17 . The method of  claim 11 , wherein the fabricating includes 3D printing. 
     
     
         18 . A method of making a device comprising:
 (a) obtaining a scan, mold, or model of an individual's oral cavity where the dental prosthesis will fit;   (b) fabricating a core dental prosthesis corresponding to the individual's scan, mold, or model of the oral cavity with PMMA polymer,   
       wherein the PMMA polymer filament one or more microsphere(s) comprising one or more drug(s). 
     
     
         19 . The method of  claim 18 , wherein the prosthesis is a denture. 
     
     
         20 . The method of  claim 18 , wherein the one or more drug(s) are chosen from antimicrobial agent(s), antifungal agent(s), antibiotic(s), antiviral(s), analgesic(s), steroid(s), immune modulator(s), fluoride, and combinations thereof. 
     
     
         21 . The method of  claim 20 , wherein the one or more drug(s) is an antifungal agent chosen from amphotericin B, flucytosine, fluconazole, ketoconazole, miconazole, terbinafine, griseofulvin, Clotrimazole, Econazole, Anidulafungin, Micafungin, Caspofungin, Butoconazole. Bifonazole, Clotrimazole, Econazole. Fenticonazole, Isoconazole, Ketoconazole, Luliconazole, Miconazole, Omoconazole, Oxiconazole, Sulconazole, Sertaconazole, Tioconazole, Albaconazole, Abafungin, amorolfin, butenafine, naftifine, and terbinafine, Epoxiconazole, Efinaconazole, Fluconazole, Itraconazole, Isavuconazole, Propiconazole, Posaconazole, Ravuconazole, Terconazole, Voriconazole, and combinations thereof. 
     
     
         22 . The method of  claim 21 , wherein the antifungal agent is amphotericin B. 
     
     
         23 . The method of  claim 18 , wherein the one or more microsphere(s) comprise PCL. 
     
     
         24 . The method of  claim 18 , wherein the fabricating includes 3D printing. 
     
     
         25 . A method of treating an individual afflicted with or suspected of having an oral or dental condition comprising:
 (a) obtaining a scan, mold, or model of the individual's oral cavity where the dental prosthesis will fit;   (b) fabricating a core dental prosthesis corresponding to the individual's scan, mold, or model of the oral cavity with a PMMA polymer;   (c) generating one or more microsphere(s)comprising one or more drug(s);   (d) coating the core dental prosthesis with the one or more microsphere(s)comprising one or more drug(s);   (e) administering the completed dental prosthesis to the individual for sufficient time to treat the oral or dental condition; and   (f) optionally, monitoring the individual's response to the dental prosthesis treatment.   
     
     
         26 . The method of  claim 25 , wherein the individual is recovering from surgery and/or a dental procedure. 
     
     
         27 . The method of  claim 25 , wherein the individual has or is suspected of having a  C. albicans  infection. 
     
     
         28 . The method of  claim 25 , wherein the one or more drug(s) is an antifungal agent chosen from amphotericin B, flucytosine, fluconazole, ketoconazole, miconazole, terbinafine, griseofulvin, Clotrimazole, Econazole, Anidulafungin, Micafungin, Caspofungin, Butoconazole. Bifonazole, Clotrimazole, Econazole. Fenticonazole, Isoconazole, Ketoconazole, Luliconazole, Miconazole, Omoconazole, Oxiconazole, Sulconazole, Sertaconazole, Tioconazole, Albaconazole, Abafungin, amorolfin, butenafine, naftifine, and terbinafine, Epoxiconazole, Efinaconazole, Fluconazole, Itraconazole, Isavuconazole, Propiconazole, Posaconazole, Ravuconazole, Terconazole, Voriconazole, and combinations thereof. 
     
     
         29 . The method of  claim 28 , wherein the antifungal agent is amphotericin B. 
     
     
         30 . The method of  claim 25 , wherein the one or more microsphere(s) comprise PCL. 
     
     
         31 . A method of treating an individual afflicted with or suspected of having an oral or dental condition comprising:
 (a) obtaining a scan, mold, or model of the individual's oral cavity where the dental prosthesis will fit;   (b) fabricating a core dental prosthesis corresponding to the individual's scan, mold, or model of the oral cavity with a PMMA polymer;   (c) administering the completed dental prosthesis to the individual for sufficient time to treat the oral or dental condition; and   (d) optionally, monitoring the individual's response to the dental prosthesis treatment,   
       wherein the PMMA polymer filament one or more microsphere(s) comprising one or more drug(s). 
     
     
         32 . The method of  claim 31 , wherein the individual is recovering from surgery and/or a dental procedure. 
     
     
         33 . The method of  claim 31 , wherein the individual has or is suspected of having a  C. albicans  infection. 
     
     
         34 . The method of  claim 31 , wherein the one or more drug(s) is an antifungal agent chosen from amphotericin B, flucytosine, fluconazole, ketoconazole, miconazole, terbinafine, griseofulvin, Clotrimazole, Econazole, Anidulafungin, Micafungin, Caspofungin, Butoconazole. Bifonazole, Clotrimazole, Econazole. Fenticonazole, Isoconazole, Ketoconazole, Luliconazole, Miconazole, Omoconazole, Oxiconazole, Sulconazole, Sertaconazole, Tioconazole, Albaconazole, Abafungin, amorolfin, butenafine, naftifine, and terbinafine, Epoxiconazole, Efinaconazole, Fluconazole, Itraconazole, Isavuconazole, Propiconazole, Posaconazole, Ravuconazole, Terconazole, Voriconazole, and combinations thereof. 
     
     
         35 . The method of  claim 34 , wherein the antifungal agent is amphotericin B. 
     
     
         36 . The method of  claim 31 , wherein the one or more microsphere(s) comprise PCL.