US2022153675A1PendingUtilityA1

Salts of treprostinil

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Assignee: UNITED THERAPEUTICS CORPPriority: Mar 15, 2013Filed: Jan 31, 2022Published: May 19, 2022
Est. expiryMar 15, 2033(~6.6 yrs left)· nominal 20-yr term from priority
Inventors:Hitesh BatraVijay SharmaSanmin YangYi Zhang
C07C 59/72A61K 31/19C07C 51/412C07C 51/41A61P 9/12
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Claims

Abstract

Provided are novel treprostinil salts as well as methods for making treprostinil salts.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A composition comprising at least 30 g of a potassium salt of treprostinil in a chemically-stable, crystalline solid form. 
     
     
         2 . The composition of  claim 1  comprising at least 40 g of the potassium salt of treprostinil in the chemically-stable, crystalline solid form. 
     
     
         3 . The composition of  claim 1  comprising at least 60 g of the potassium salt of treprostinil in the chemically-stable, crystalline solid form. 
     
     
         4 . The composition of  claim 1  comprising at least 80 g of the potassium salt of treprostinil in the chemically-stable, crystalline solid form. 
     
     
         5 . The composition of  claim 1 , wherein a purity of the potassium salt of treprostinil in the composition is at least 99%. 
     
     
         6 . The composition of  claim 1 , wherein a purity of the potassium salt of treprostinil in the composition is at least 99.1%. 
     
     
         7 . The composition of  claim 1 , wherein a melting temperature of the potassium salt of treprostinil is from 180° C. to 182° C.

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