Applications for estradiol in preparing anti-small cell lung cancer and/or ovarian cancer and/or osteosarcoma products

Abstract

This invention discloses uses for estradiol in preparing anti-small cell lung cancer and/or ovarian cancer and/or osteosarcoma products. This invention provides uses for estradiol in preparing anti-small cell lung cancer and/or ovarian cancer and/or osteosarcoma products. From carrying out cancer drug repositioning for the FDA- and CFDA-approved drug estradiol, experiments for this invention show, based on screening of non-anti-cancer drugs for various cancer cell lines (tissue types) and mutation sites, that estradiol has a new use as an anti-small cell lung cancer and/or ovarian cancer and/or osteosarcoma medication, thus achieving a new purpose for an old drug.

What is claimed is: 
     
         1 . A method for treating osteosarcoma in a subject comprising administering an effective amount of estradiol to the subject. 
     
     
         2 . A method of inhibiting the proliferation of osteosarcoma cancer cells comprising contacting the cells with an effective amount of estradiol. 
     
     
         3 . The method of  claim 2 , wherein the osteosarcoma cancer cells are U2OS cells. 
     
     
         4 . A pharmaceutical composition for use in treating osteosarcoma cancer comprising estradiol. 
     
     
         5 . A kit comprising the pharmaceutical composition of  claim 4  and instructions for use in treating osteosarcoma cancer. 
     
     
         6 . The method of  claim 1 , wherein the effective amount of estradiol is at a concentration of about 0.1 μM or higher.