Drug and small molecule delivery via microbial vesicles

Abstract

A method comprises preparing initial agent molecules and applying the initial agent molecules to microbes for extracellular vesiculation. Microbial vesicles are generated which contain the initial agent molecules by the microbes. The packaged microbial vesicles are then administered to a host organism. By administering the initial agent molecules as a microbial vesicle package, binding proteins for the initial agent molecules may be co-administered, and cells may uptake numerous initial agent molecules concurrently.

1 . A method, comprising:
 preparing initial agent molecules;   applying the initial agent molecules to microbes for extracellular vesiculation;   generating microbial vesicles containing the initial agent molecules by the microbes;   preparing the microbial vesicles for storage and packaging; and   administering the packaged microbial vesicles to a host organism.