Arylquinazolines

Abstract

The invention relates to novel compounds of the formula (I) which can be used for the inhibition of serine-threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation.

We claim: 
     
         1 - 20 . (canceled) 
     
     
         21 . A compound selected from the following:
 (3,5-Difluoro-pyridin-4-yl)-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]methanol;   (4-Chloro-5-fluoro-pyridin-3-yl)-[4-fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(4-methoxy-pyridazin-3-yl)methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(6-chloro-5-methoxypyridazin-3-yl)-methanol;   (3-Chloro-6-methoxy-pyridazin-4-yl)-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(6-chloro-4-methoxypyridazin-3-yl)-methanol;   (6-Chloro-4-methoxy-pyridazin-3-yl)-[4-fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-pyrrolidin-1-yl-pyrazin-2-yl)methanol;   [4-Fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(3-methoxy-pyrazin-2-yl)methanol;   (3,5-Dichloro-pyridin-4-yl)-[4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(4-methoxy-pyridazin-3-yl)-methanol;   (3-Chloro-pyrazin-2-yl)-[4-fluoro-3-(6-morpholin-4-yl-thieno [3,2-d]pyrimidin-4-yl)-phenyl]-methanol;   (S)-(3-Chloro-pyrazin-2-yl)-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-pyridazin-3-yl-methanol;   (3-Chloro-5-methoxy-pyridin-2-yl)-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   [4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-[3-(oxetan-3-yloxy)-pyrazin-2-yl]-methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-pyrazin-2-yl-methanol;   (3,6-Dichloro-pyrazin-2-yl)-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   (3-Chloro-pyrazin-2-yl)-[4-fluoro-3-(6-morpholin-4-ylthieno-[3,2-d]-pyrimidin-4-yl)-phenyl]-methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-pyrazolo[methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(4-methoxypyrido[3,4-d] pyridazin-1-yl)-methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(6-chloro-pyridazin-3-yl)methanol;   (3-Chloro-pyridin-2-yl)-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxy-methyl}-pyridazine-3-carboxylic acid methylamide;   6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxymethyl}-2-methyl-2H-pyridazin-3-one;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(5-methylpyridazin-3-yl)methanol;   2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-pyridazin-3-yl-methanol;   [2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-pyridazin-3-yl-methanol;   (6-Chloro-pyridazin-3-yl)-[2,4-difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]methanol;   6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxy-methyl}-pyridazine-3-carboxylic acid dimethylamide;   [2,4-Difluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-imidazo[1,2-b]pyridazin-6-ylmethanol;   [4-Fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(5-methoxy-pyrazin-2-yl)methanol;   (3-Chloro-pyrazin-2-yl)-[4-fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-methanol;   6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxy-methyl}-pyridazine-3-carboxylic acid;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-imidazo[1,2-b]pyridazin-6-ylmethanol;   6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxy-methyl}-pyridazine-3-carboxylic acid methyl ester;   6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]hydroxymethyl}-2-methyl-2H-pyridazin-3-one;   6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxymethyl}-pyridazine-3-carboxylic acid amide;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-chloro-pyrazin-2-yl)methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-pyridazin-3-yl-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(5-methoxy-pyrimidin-2-yl)methanol;   (6-Dimethylamino-pyridazin-3-yl)-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(6-methyl-pyridazin-3-yl)methanol;   (R)-[4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(6-methoxy-pyridazin-3-yl)methanol;   (S)-[4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(6-methoxy-pyridazin-3-yl)methanol;   4-{2-Fluoro-5-[methoxy-(6-methoxy-pyridazin-3-yl)-methyl]-phenyl}-7-morpholin-4-ylquinazoline;   6-{[4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxymethyl}-2H-pyridazin-3-one;   (3-Chloro-5-fluoro-pyridin-4-yl)-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-methyl-pyrazin-2-yl)-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-trifluoromethyl-pyridin-2-yl)methanol;   (S)-[4-Fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(3-methyl-pyrazin-2-yl)methanol;   [4-Fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(5-methoxy-pyrimidin-4-yl)methanol;   [2,4-Difluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(3,6-dimethyl-pyrazin-2-yl)methanol;   [2-Chloro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-thieno[3,2-d]pyrimidin-4-ylmethanol;   6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxymethyl}-2-ethyl-2H-pyridazin-3-one;   2-(2-Amino-ethyl)-6-{[2-chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxymethyl}-2H-pyridazin-3-one;   6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxymethyl}-2-cyclopropyl-2H-pyridazin-3-one;   2-(3-{[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxymethyl}-6-oxo-6H-pyridazin-1-yl)acetamide;   6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxymethyl}-2-(2-hydroxy-ethyl)-2H-pyridazin-3-one;   [2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-[6-(oxetan-3-yloxy)pyridazin-3-yl]methanol;   2-(6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxymethyl}-pyridazin-3-yloxy)-propionitrile;   2-(3-{[4-fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxymethyl}-pyrazin-2-yloxy)ethanol;   2-(3-{[4-fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]hydroxymethyl}-pyrazin-2-ylamino)-ethanol;   3-(6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-yl)¬quinazolin-4-yl)-phenyl]-hydroxy-methyl}-pyridazin-3-yl-oxy)-propionitrile;   [2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(6-methylsulfanylpyridazin-3-yl)methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(6-methoxy-5-methylpyridazin-3-yl)methanol;   2-(6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxymethyl}-pyridazin-3-yloxy)-acetamide;   [2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-[6-(2-methoxyethoxy)pyridazin-3-yl]-methanol;   (6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxymethyl}pyridazin-3-yloxy)-acetic acid;   (6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxymethyl}pyridazin-3-yloxy)-acetic acid methyl ester;   [2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-[6-(2,2,2-trifluoroethoxy)-pyridazin-3-yl]-methanol;   2-(6{[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxymethyl}-pyridazin-3-yloxy)-ethanol;   (3-Amino-pyrazin-2-yl)-[2-chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-methanol;   6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxymethyl}pyridazine-3-carbonitrile;   (6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxymethyl}pyridazin-3-yloxy)-acetonitrile;   (6-Difluoromethoxy-pyridazin-3-yl)-[4-fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-methanol;   1-[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-1-(6-methoxy-pyridazin-3-yl)-prop-2-yn-1-ol;   1-[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-2,2-difluoro-1-(6-methoxypyridazin-3-yl)-ethanol;   1-[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-1-(6-methoxy-pyridazin-3-yl)-ethanol;   [2-Chloro-4-fluoro-5-(6-morpholin-4-yl-thieno[3,2-d]pyrimidin-4-yl)-phenyl]-(6-methoxypyridazin-3-yl)-methanol;   [2-Chloro-5-(2-chloro-7-morpholin-4-ylquinazolin-4-yl)-4-fluorophenyl]-(6-methoxy-pyridazin-3-yl)-methanol;   [6-(2-Dimethylamino-ethoxy)pyridazin-3-yl]-[4-fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-methanol;   (6-Ethoxy-pyridazin-3-yl)-[4-fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]methanol; and   (R)-[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(6-methoxy-pyridazin-3-yl)methanol;   or a physiologically acceptable salt, tautomer and/or stereoisomer thereof, including mixtures thereof in all ratios.   
     
     
         22 . A compound selected from the following:
 [2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(6-methoxy-pyridazin-3-yl)methanol;   {3-[7-(3,6-Dihydro-2H-pyran-4-yl)-quinazolin-4-yl]-4-fluoro-phenyl}-thiazol-2-ylmethanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(4-methylaminomethyl-thiazol-2-yl)-methanol;   [4-Fluoro-3-(6-morpholin-4-yl-thieno[3,2-d]pyrimidin-4-yl)-phenyl]-thiazol-2-ylmethanol;   [3-(7-Morpholin-4-ylquinazolin-4-yl)-phenyl]-thiazol-2-ylmethanol;   1-[5-(7-Morpholin-4-ylquinazolin-4-yl)pyridin-3-yl]-1-thiazol-2-ylethanol;   1-[4-Fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-1-thiazol-2-ylethanol;   [3-Fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-thiazol-2-ylmethanol;   [2-Fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-thiazol-2-ylmethanol;   [3,4-Difluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-thiazol-2-ylmethanol;   7-Morpholin-4-yl-4-piperidin-1-yl-thieno[3,2-d]pyrimidine;   [5-(7-Morpholin-4-ylquinazolin-4-yl)pyridin-3-yl]-thiazol-2-ylmethanol;   4-[2-Fluoro-5-(methoxy-thiazol-2-ylmethyl)-phenyl]-7-morpholin-4-ylquinazoline;   [6-Fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)pyridin-3-yl]-thiazol-2-ylmethanol;   [3-(6-Morpholin-4-yl-thieno[3,2-d]pyrimidin-4-yl)-phenyl]-thiazol-2-ylmethanol;   (S)-[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(4-hydroxymethyl-thiazol-2-yl)methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(4-ethylaminomethyl-thiazol-2-yl)-methanol;   (4-Aminomethyl-thiazol-2-yl)-[2-chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   [4-Fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(1-methyl-1H-pyrazol-4-yl)methanol;   (4,5-Dimethyl-thiazol-2-yl)-[2-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)pyridin-3-yl]-methanol;   (4,5-Dimethyl-thiazol-2-yl)-[6-fluoro-5-(7-morpholin-4-yl-pyrido[4,3-d]pyrimidin-4-yl)pyridin-3-yl]-methanol;   (1-tert-Butyl-1H-pyrazol-4-yl)-[2-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-pyridin-3-yl]-methanol;   [4-Fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(5-hydroxymethyl-4-methyl-thiazol-2-yl)-methanol;   1-(2-{[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxymethyl}thiazol-4-yl)-ethanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(1-ethyl-1H-pyrazol-4-yl)-methanol;   [4-Fluoro-2-methyl-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-thiazol-2-yl-methanol;   [3-(2-Ethynyl-7-morpholin-4-ylquinazolin-4-yl)-4-fluoro-phenyl]-thiazol-2-yl-methanol;   [4-Fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-thiazol-2-yl-methanol;   [3-(2-Chloro-7-morpholin-4-ylquinazolin-4-yl)-4-fluoro-phenyl]-(2-methyl-2H-pyrazol-3-yl)-methanol;   [2,4-Difluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-pyridin-3-yl-methanol;   [2,4-Difluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-pyridin-2-yl-methanol;   6-{[2,4-Difluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxymethyl}-2-methyl-2H-pyridazin-3-one;   [2,4-Difluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(6-methoxy-pyridin-3-yl)methanol;   [2,4-Difluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-6-yl-methanol;   [2,4-Difluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-imidazo[1,2-a]pyrazin-6-ylmethanol;   [2,4-Difluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-(5-methoxy-pyridin-2-yl)methanol;   [2-Chloro-5-(5,6-dideuterio-7-morpholino-quinazolin-4-yl)-4-fluoro-phenyl]-(6-methoxypyridazin-3-yl)-methanol;   3-(5,6-Dideuterio-7-morpholinoquinazolin-4-yl)-4-fluorophenyl]-(3-methylpyrazin-2-yl)methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-ylpyrido[3,2-d]pyrimidin-4-yl)-phenyl]-(6-methoxypyridazin-3-yl)methanol;   2-[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-2-(3-methoxy-pyrazin-2-yl)N-methyl-acetamide;   2-(3-Chloro-pyridin-2-yl)-2-[4-fluoro-3-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-N-methylacetamide;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-pyrido[3,2-d]pyrimidin-4-yl)-phenyl]-(3-methoxypyrazin-2-yl)-methanol;   (S)-[4-Fluoro-3-(7-morpholin-4-yl-pyrido[3,2-d]pyrimidin-4-yl)-phenyl]-(3-methyl-pyrazin-2-yl)methanol;   2-[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-2-imidazo[1,2-b]pyridazin-6-yl-N-methyl-acetamide;   [4-Fluoro-3-(7-morpholin-4-yl-pyrido[3,2-d]pyrimidin-4-yl)-phenyl]-(3-methyl-pyrazin-2-yl)methanol;   (R)-[4-Fluoro-3-[7-(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)-quinazolin-4-yl]-phenyl]-(3-methyl-pyrazin-2-yl)-methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-pyrido[3,2-d]pyrimidin-4-yl)-phenyl]-(3-methylpyrazin-2-yl)-methanol;   [2-Chloro-4-fluoro-5-[7-(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)-quinazolin-4-yl]-phenyl]-(3-methoxypyrazin-2-yl)-methanol;   (S)-[4-Fluoro-3-[7-(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)-quinazolin-4-yl]-phenyl]-(3-methylpyrazin-2-yl)-methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-pyrido[3,2-d]pyrimidin-4-yl)-phenyl]-(3-methoxypyrazin-2-yl)-methanol;   (S)-[4-fluoro-3-(5-fluoro-7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-methyl-pyrazin-2-yl)methanol;   2-[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-N-methyl-2-(3-methylpyrazin-2-yl)-acetamide;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-pyrido[3,2-d]-pyrimidin-4-yl)-phenyl]-(6-methoxypyridazin-3-yl)-methanol;   [2-Chloro-4-fluoro-5-[7-(2,2,3,3,5,5,6,6-octadeuterio-morpholin-4-yl)-quinazolin-4-yl-]-phenyl]-(3-methoxy-pyrazin-2-yl)-methanol; and   2-[2-Chloro-4-fluoro-5-(5-fluoro-7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-(3-methoxypyrazin-2-yl)-acetamide;   or a physiologically acceptable salt, tautomer and/or stereoisomer thereof, including mixtures thereof in all ratios.   
     
     
         23 . A compound selected from the following:
 2-[2-Chloro-4-fluoro-5-(6-morpholin-4-yl-thieno[3,2-d]-pyrimidin-4-yl)-phenyl]-2-(3-methylpyrazin-2-yl)-acetamide;   2-[4-Fluoro-3-(6-morpholin-4-yl-thieno[3,2-d]-pyrimidin-4-yl)-phenyl]-2-(3-methyl-pyrazin-2-yl)-acetamide;   2-[2-Chloro-4-fluoro-5-(6-morpholin-4-yl-thieno[3,2-d]-pyrimidin-4-yl)-phenyl]-2-(6-methoxypyridazin-3-yl)-acetamide;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-[1,2,4]-triazolo[1,5-a]-pyrazin-8-ylmethanol;   2-[4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-[1,2,4]-triazolo[1,5-a]-pyrazin-8-ylacetamide;   2-[4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-thieno-[2,3 d]-pyridazin-7-ylacetamide;   2-[4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-thieno-[2,3 d]-pyridazin-4-ylacetamide;   (6-Chloro-3-methoxy-pyridazin-4-yl)-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxy-methyl}-2-methyl-4,5-dihydro-2H-pyridazin-3-one;   2-[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-(3-chloro-pyridin-2-yl)acetamide;   6-{Carbamoyl-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methyl}-pyrazine-2-carboxylic acid amide;   2-[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-pyridin-3-yl-acetamide;   2-[2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-pyridin-3-ylacetamide;   2-[4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-pyridin-3-ylacetamide;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(6-methyl-pyrazin-2-yl)-methanol;   2-(5-Chloro-pyridin-3-yl)-2-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-acetamide;   2-[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-[1,2,4]triazolo[4,3-a]pyridin-5-ylacetamide;   2-[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-pyridazin-3-ylacetamide;   2-[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-(3,5-dimethyl-pyrazin-2-yl)-acetamide;   (6-Amino-pyrazin-2-yl)-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   2-[2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-(3-methyl-pyrazin-2-yl)-acetamide;   2-[2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-(3-methoxy-pyrazin-2-yl)acetamide;   2-[4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-(3-methoxy-pyrazin-2-yl)acetamide;   2-[2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-(6-methoxy-pyridazin-3-yl)acetamide;   2-[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-(3-methoxy-pyridazin-4-yl)-acetamide;   2-[4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-(6-methoxy-pyridazin-3-yl)acetamide;   2-(3-Chloro-pyridin-2-yl)-2-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-acetamide;   (5,6-Dimethyl-pyrazin-2-yl)-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   2-(3,5-Dimethyl-pyrazin-2-yl)-2-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-acetamide;   2-[2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-(3-methoxy-pyrazin-2-yl)acetamide;   2-[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-(3-methoxy-pyrazin-2-yl)acetamide;   2-(3,5-Difluoro-pyridin-4-yl)-2-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-acetamide;   2-(4-Chloro-5-fluoro-pyridin-3-yl)-2-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-acetamide;   2-[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-imidazo[1,2-b]pyridazin-6-yl-acetamide;   2-[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-(3-methyl-pyrazin-2-yl)acetamide;   6-{[4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxy-methyl}-2-methyl-2H-pyridazin-3-one;   2-[4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-(3-methyl-pyrazin-2-yl)-acetamide;   2-[2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-(3-methyl-pyrazin-2-yl)acetamide;   5-Chloro-6-{[2-chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxy-methyl}-pyrimidin-4-ol;   (3-methyl-pyrazin-2-yl)-[3-(7-morpholin-4-yl-quinazolin-4-yl)-4-oxocyclohexa-2,5-dien-(E)ylidene]-acetic acid;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-thieno[2,3-d]pyridazin-7-yl-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-thieno[2,3-d]pyridazin-4-yl-methanol;   7-[[4-Fluoro-3-(7-morpholino-quinazolin-4-yl)-phenyl]-hydroxy-methyl]-5H-thieno-[2,3-d]pyridazin-4-one;   4-[[4-Fluoro-3-(7-morpholino-quinazolin-4-yl)-phenyl]-hydroxy-methyl]-6H-thieno[2,3-d]pyridazin-7-one;   6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxymethyl}-1,4-dimethyl-1H-pyridin-2-one;   6-{[4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxymethyl}-1,4-dimethyl-1H-pyridin-2-one;   [2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-thieno[2,3-d]pyridazin-4-yl-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-3-ylmethanol;   [2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(9-methyl-9H-purin-6-yl)-methanol;   2-[2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-pyrrolo[1,2a]pyrazin-1-ylacetamide;   4-[2-Fluoro-5-(3-methyl-pyrazin-2-ylmethyl)-phenyl]-7-morpholin-4-yl-quinazoline;   [2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-5-ylmethanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-[1,2,4]-triazolo[4,3-a]pyrazin-8-ylmethanol;   4-{2-Fluoro-5-[methoxy-(3-methyl-pyrazin-2-yl)-methyl]-phenyl}-7-morpholin-4-ylquinazoline;   [2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3,5-dimethyl-pyrazin-2-yl)methanol;   [2-Fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(6-methoxy-pyridazin-3-yl)-methanol;   [2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-pyrrolo[1,2-a]pyrazin-1-yl-methanol;   2-{[4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxy-methyl}-3-methyl-3H-pyrimidin-4-one;   6-{[2-Fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxy-methyl}-1-methyl-1H-pyridin-2-one;   2-{[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxy-methyl}-3-methyl-3H-pyrimidin-4-one;   [2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-imidazo[1,2 a]pyrazin-8-yl-methanol;   [2-Fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(9-methyl-9H-purin-6-yl)-methanol;   [2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(9-methyl-9H-purin-6-yl)-methanol;   [2-Fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-imidazo[1,2 a]pyrazin-8-yl-methanol;   [2-Fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-5-ylmethanol;   [2-Fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-furo[3,2-d]pyrimidin-4-yl-methanol;   2-[2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-2-(5-methyl-pyrimidin-4-yl)acetamide;   [2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-3-ylmethanol;   6-{[2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxy-methyl}-1-methyl-1H-pyridin-2-one;   6-{[2-Chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)-phenyl]-hydroxy-methyl}-1-methyl-1H-pyridin-2-one;   (R)-[2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(7-methyl-7H-purin-6-yl)methanol;   [2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-methanol;   (S)-[2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(7-methyl-7H-purin-6-yl)methanol;   [2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-methanol;   [2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(5-fluoro-pyrimidin-4-yl)-methanol;   [2-Fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-methanol;   [2-Fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(5-methyl-pyrimidin-4-yl)-methanol;   [2-Fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-methyl-pyrazin-2-yl)-methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-imidazo[1,2 a]pyrazin-8-ylmethanol;   1-Ethyl-6-{[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-hydroxy-methyl}-1H-pyridin-2-one;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-methanol;   [2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-methanol;   [2-Fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-thieno[2,3-d]pyrimidin-4-yl-methanol;   [2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(5-methoxy-pyrimidin-4-yl)-methanol;   [2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-methoxy-pyrazin-2-yl)-methanol;   [2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-furo[2,3-d]pyrimidin-4-yl-methanol;   [2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(5-methyl-pyrimidin-4-yl)-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(9-methyl-9H-purin-6-yl)-methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(7-methyl-7H-purin-6-yl)methanol;   [2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-methyl-pyrazin-2-yl)-methanol;   [2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-thieno[2,3-d]pyrimidin-4-yl-methanol;   [2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(7-methyl-7H-purin-6-yl)-methanol;   [2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-furo[3,2-d]pyrimidin-4-yl-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(7-methyl-7H-purin-6-yl)-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-thieno[2,3-d]pyrimidin-4-yl-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-thieno[3,2-d]pyrimidin-4-yl-methanol;   [2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-thieno[3,2-d]pyrimidin-4-ylmethanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-furo[3,2-d]pyrimidin-4-ylmethanol;   [2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-furo[3,2-d]pyrimidin-4-yl-methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(5-methoxy-pyrimidin-4-yl)methanol;   [2,4-Difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(5-methoxy-pyrimidin-4-yl)methanol;   (3-Difluoromethoxy-pyrazin-2-yl)-[2,4-difluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   (R)-[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-methoxy-pyrazin-2-yl)methanol;   (S)-[2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-methoxy-pyrazin-2-yl)methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-methyl-pyrazin-2-yl)methanol;   [2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(6-methoxy-pyridazin-3-yl)-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-iodo-pyrazin-2-yl)-methanol;   (3-Ethoxy-pyridin-2-yl)-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   (3-Difluoromethoxy-pyrazin-2-yl)-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   [2-Chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-methoxy-pyrazin-2-yl)methanol;   [2-Chloro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-pyridazin-3-yl-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-methyl-pyridin-2-yl)-methanol;   (3-Bromo-5-methoxy-pyridin-2-yl)-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-trifluoro-methoxypyridin-2-yl)methanol;   [4-Fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(3-trifluoro-methylpyrazin-2-yl)methanol; and   (3-Bromo-pyridin-2-yl)-[4-fluoro-3-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-methanol;   or a physiologically acceptable salt, tautomer and/or stereoisomer thereof, including mixtures thereof in all ratios.   
     
     
         24 . A pharmaceutical composition comprising a compound according to  claim 21 , or a physiologically acceptable salt, tautomer, and/or stereoisomer thereof, including mixtures thereof in all ratios; and a pharmaceutically tolerated adjuvant. 
     
     
         25 . A pharmaceutical composition comprising a compound according to  claim 22 , or a physiologically acceptable salt, tautomer, and/or stereoisomer thereof, including mixtures thereof in all ratios; and a pharmaceutically tolerated adjuvant. 
     
     
         26 . A pharmaceutical composition comprising a compound according to  claim 23 , or a physiologically acceptable salt, tautomer, and/or stereoisomer thereof, including mixtures thereof in all ratios; and a pharmaceutically tolerated adjuvant.