Modified hydrophobic excipient and preparation method thereof

Abstract

The present invention relates to a modified hydrophobic excipient having a molecular formula of: where R is a hydrophobic natural compound or a hydrophobic synthetic compound with one to three hydroxyl groups (n=1-3); and R1 is an α-amino protecting group, and R2 is an amino acid side chain, wherein, when m=0, R is reacted with an amino acid derivative with a protecting group by esterification to form a hydrophobic excipient carrying the amino acid derivative with a protecting group; or when m=1, R is firstly introduced with an amino acid linking arm of different chain lengths (l=1, 2, 4, 6) via an ester group, and then introduced with an amino acid derivative with a protecting group.

What is claimed is: 
     
         1 . A modified hydrophobic excipient, wherein the molecular formula is as follows: 
       
         
           
           
               
               
           
         
         where R is a hydrophobic natural compound or a hydrophobic synthetic compound with one to three hydroxyl groups (n=1-3); and R1 is an α-amino protecting group, and R2 is an amino acid side chain, wherein, when m=0, R is reacted with an amino acid derivative with a protecting group by esterification to form a hydrophobic excipient carrying the amino acid derivative with a protecting group; or when m=1, R is firstly introduced with an amino acid linking arm of different chain lengths (l=1, 2, 4, 6) via an ester group, and then introduced with an amino acid derivative with a protecting group. 
       
     
     
         2 . The modified hydrophobic excipient of  claim 1 , wherein the hydrophobic natural compound or hydrophobic synthetic compound with one to three hydroxyl groups (n=1-3) comprises a triglyceride with one to three hydroxyl groups or a derivative thereof or a hydrophobic derivative of a steroid, or is obtained by introducing a hydroxyl group into an unsaturated triglyceride through an epoxy reaction and an electrophilic reaction or by introducing a hydroxyl group into an unsaturated triglyceride through a Michael reaction under a photocatalytic condition. 
     
     
         3 . The modified hydrophobic excipient of  claim 2 , wherein the natural triglyceride with one to three hydroxyl groups is castor oil, and the derivative of the natural triglyceride with one to three hydroxyl groups is a hydrogenated derivative of castor oil. 
     
     
         4 . The modified hydrophobic excipient of  claim 2 , wherein the hydrophobic derivative of the steroid is any one selected from a group consisting of an ester derivative or an amide derivative of cholic acid, an ester derivative or an amide derivative of deoxycholic acid, an ester derivative or an amide derivative of lithocholic acid, and an ester derivative or an amide derivative of glycocholic acid. 
     
     
         5 . The modified hydrophobic excipient of  claim 1 , wherein the derivative of the amino acid is any one selected from a group consisting of N-fluorenylmethoxycarbonyl-N′-tert-butoxycarbonyl-L-lysine, N-fluorenylmethoxycarbonyl-N′-tert-butoxycarbonyl-D-lysine, N-benzyloxycarbonyl-N′-tert-butoxycarbonyl-L-lysine, N-benzyloxycarbonyl-N′-tert-butoxycarbonyl-D-lysine, N-fluorenylmethoxycarbonyl-N′-benzyloxycarbonyl-L-lysine, N-fluorenylmethoxycarbonyl-N′-benzyloxycarbonyl-D-lysine, N-fluorenylmethoxycarbonyl-N′-fluorenylmethoxycarbonyl-L-lysine, N-fluorenylmethoxycarbonyl-N′-fluorenylmethoxycarbonyl-D-lysine, N-benzyloxycarbonyl-N′-benzyloxycarbonyl-L-lysine, N-benzyloxycarbonyl-N′-benzyloxycarbonyl-D-lysine, N-benzyloxycarbonyl-N′-fluorenylmethoxycarbonyl-L-lysine, N-benzyloxycarbonyl-N′-fluorenylmethoxycarbonyl-D-lysine, N-tert-butoxycarbonyl-N′-tert-butoxycarbonyl-L-lysine, N-tert-butoxycarbonyl-N′-tert-butoxycarbonyl-D-lysine, N-tert-butoxycarbonyl-N′-fluorenylmethoxycarbonyl-L-lysine, N-tert-butoxycarbonyl-N′-fluorenylmethoxycarbonyl-D-lysine, N-tert-butoxycarbonyl-N′-benzyloxycarbonyl-L-lysine, N-tert-butoxycarbonyl-N′-benzyloxycarbonyl-D-lysine, N-fluorenylmethoxycarbonyl-N′-tert-butoxycarbonyl-L-ornithine, N-fluorenylmethoxycarbonyl-N′-tert-butoxycarbonyl-D-ornithine, N-benzyloxycarbonyl-N′-tert-butoxycarbonyl-L-ornithine, N-benzyloxycarbonyl-N′-tert-butoxycarbonyl-D-ornithine, N-fluorenylmethoxycarbonyl-N′-fluorenylmethoxycarbonyl-L-ornithine, N-fluorenylmethoxycarbonyl-N′-benzyloxycarbonyl-L-ornithine, N-fluorenylmethoxycarbonyl-N′-benzyloxycarbonyl-D-ornithine, N-fluorenylmethoxycarbonyl-N′-fluorenylmethoxycarbonyl-L-ornithine, N-fluorenylmethoxycarbonyl-N′-fluorenylmethoxycarbonyl-D-ornithine, N-benzyloxycarbonyl-N′-benzyloxycarbonyl-L-ornithine, N-benzyloxycarbonyl-N′-benzyloxycarbonyl-D-ornithine, N-benzyloxycarbonyl-N′-fluorenylmethoxycarbonyl-L-ornithine, N-benzyloxycarbonyl-N′-fluorenylmethoxycarbonyl-D-ornithine, N-tert-butoxycarbonyl-N′-tert-butoxycarbonyl-L-ornithine, N-tert-butoxycarbonyl-N′-tert-butoxycarbonyl-D-ornithine, N-tert-butoxycarbonyl-N′-fluorenylmethoxycarbonyl-L-ornithine, N-tert-butoxycarbonyl-N′-fluorenylmethoxycarbonyl-D-ornithine, N-tert-butoxycarbonyl-N′-benzyloxycarbonyl-L-ornithine, N-tert-butoxycarbonyl-N′-benzyloxycarbonyl-D-ornithine, N-fluorenylmethoxycarbonyl-N′-tert-butoxycarbonyl-L-tryptophan, N-fluorenylmethoxycarbonyl-N′-tert-butoxycarbonyl-D-tryptophan, N-benzyloxycarbonyl-N′-tert-butoxycarbonyl-L-tryptophan, N-benzyloxycarbonyl-N′-tert-butoxycarbonyl-D-tryptophan, N-fluorenylmethoxycarbonyl-N′-benzyloxycarbonyl-L-tryptophan, N-fluorenylmethoxycarbonyl-N′-benzyloxycarbonyl-D-tryptophan, N-fluorenylmethoxycarbonyl-N′-fluorenylmethoxycarbonyl-L-tryptophan, N-fluorenylmethoxycarbonyl-N′-fluorenylmethoxycarbonyl-D-tryptophan, N-benzyloxycarbonyl-N′-benzyloxycarbonyl-L-tryptophan, N-benzyloxycarbonyl-N′-benzyloxycarbonyl-D-tryptophan, N-tert-butoxycarbonyl-N′-tert-butoxycarbonyl-L-tryptophan, N-tert-butoxycarbonyl-N′-tert-butoxycarbonyl-D-tryptophan, N-fluorenylmethoxycarbonyl-O′-benzyl ester-L-aspartic acid, N-fluorenylmethoxycarbonyl-O′-benzyl ester-D-aspartic acid, N-benzyloxycarbonyl-O′-benzyl ester-L-aspartic acid, N-benzyloxycarbonyl-O′-benzyl ester-D-aspartic acid, N-tert-butoxycarbonyl-O′-benzyl ester-L-aspartic acid, N-tert-butoxycarbonyl-O′-benzyl ester-D-aspartic acid, N-tert-butoxycarbonyl-O-benzyl ester-L-aspartic acid, N-tert-butoxycarbonyl-O-benzyl ester-D-aspartic acid, N-fluorenylmethoxycarbonyl-O′-methyl ester-L-aspartic acid, N-fluorenylmethoxycarbonyl-O′-methyl ester-D-aspartic acid, N-benzyloxycarbonyl-O′-methyl ester-L-aspartic acid, N-benzyloxycarbonyl-O′-methyl ester-D-aspartic acid, N-tert-butoxycarbonyl-O′-methyl ester-L-aspartic acid, N-tert-butoxycarbonyl-O′-methyl ester-D-aspartic acid, N-tert-butoxycarbonyl-O-methyl ester-L-aspartic acid, N-tert-butoxycarbonyl-O-methyl ester-D-aspartic acid, N-fluorenylmethoxycarbonyl-O′-ethyl ester-L-aspartic acid, N-fluorenylmethoxycarbonyl-O′-ethyl ester-D-aspartic acid, N-benzyloxycarbonyl-O′-ethyl ester-L-aspartic acid, N-benzyloxycarbonyl-O′-ethyl ester-D-aspartic acid, N-tert-butoxycarbonyl-O′-ethyl ester-L-aspartic acid, N-tert-butoxycarbonyl-O′-ethyl ester-D-aspartic acid, N-tert-butoxycarbonyl-O-ethyl ester-L-aspartic acid, N-tert-butoxycarbonyl-O-ethyl ester-D-aspartic acid, N-fluorenylmethoxycarbonyl-O′-tert-butyl ester-L-aspartic acid, N-fluorenylmethoxycarbonyl-O′-tert-butyl ester-D-aspartic acid, N-benzyloxycarbonyl-O′-tert-butyl ester-L-aspartic acid, N-benzyloxycarbonyl-O′-tert-butyl ester-D-aspartic acid, N-tert-butoxycarbonyl-O′-tert-butyl ester-L-aspartic acid, N-tert-butoxycarbonyl-O′-tert-butyl ester-D-aspartic acid, N-tert-butoxycarbonyl-O-tert-butyl ester-L-aspartic acid, N-tert-butoxycarbonyl-O-tert-butyl ester-D-aspartic acid, N-fluorenylmethoxycarbonyl-O′-allyl ester-L-aspartic acid, N-fluorenylmethoxycarbonyl-O′-allyl ester-D-aspartic acid, N-benzyloxycarbonyl-O′-allyl ester-L-aspartic acid, N-benzyloxycarbonyl-O′-allyl ester-D-aspartic acid, N-tert-butoxycarbonyl-O′-allyl ester-L-aspartic acid, N-tert-butoxycarbonyl-O′-allyl ester-D-aspartic acid, N-tert-butoxycarbonyl-O-allyl ester-L-aspartic acid, N-tert-butoxycarbonyl-O-allyl ester-D-aspartic acid, N-fluorenylmethoxycarbonyl-O′-benzyl ester-L-glutamic acid, N-fluorenylmethoxycarbonyl-O′-benzyl ester-D-glutamic acid, N-benzyloxycarbonyl-O′-benzyl ester-L-glutamic acid, N-benzyloxycarbonyl-O′-benzyl ester-D-glutamic acid, N-tert-butoxycarbonyl-O′-benzyl ester-L-glutamic acid, N-tert-butoxycarbonyl-O′-benzyl ester-D-glutamic acid, N-tert-butoxycarbonyl-O-benzyl ester-L-glutamic acid, N-tert-butoxycarbonyl-O-benzyl ester-D-glutamic acid, N-fluorenylmethoxycarbonyl-O′-methyl ester-L-glutamic acid, N-fluorenylmethoxycarbonyl-O′-methyl ester-D-glutamic acid, N-benzyloxycarbonyl-O′-methyl ester-L-glutamic acid, N-benzyloxycarbonyl-O′-methyl ester-D-glutamic acid, N-tert-butoxycarbonyl-O′-methyl ester-L-glutamic acid, N-tert-butoxycarbonyl-O′-methyl ester-D-glutamic acid, N-tert-butoxycarbonyl-O-methyl ester-L-glutamic acid, N-tert-butoxycarbonyl-O-methyl ester-D-glutamic acid, N-fluorenylmethoxycarbonyl-O′-ethyl ester-L-glutamic acid, N-fluorenylmethoxycarbonyl-O′-ethyl ester-D-glutamic acid, N-benzyloxycarbonyl-O′-ethyl ester-L-glutamic acid, N-benzyloxycarbonyl-O′-ethyl ester-D-glutamic acid, N-tert-butoxycarbonyl-O′-ethyl ester-L-glutamic acid, N-tert-butoxycarbonyl-O′-ethyl ester-D-glutamic acid, N-tert-butoxycarbonyl-O-ethyl ester-L-glutamic acid, N-tert-butoxycarbonyl-O-ethyl ester-D-glutamic acid, N-fluorenylmethoxycarbonyl-O′-tert-butyl ester-L-glutamic acid, N-fluorenylmethoxycarbonyl-O′-tert-butyl ester-D-glutamic acid, N-benzyloxycarbonyl-O′-tert-butyl ester-L-glutamic acid, N-benzyloxycarbonyl-O′-tert-butyl ester-D-glutamic acid, N-tert-butoxycarbonyl-O′-tert-butyl ester-L-glutamic acid, N-tert-butoxycarbonyl-O′-tert-butyl ester-D-glutamic acid, N-tert-butoxycarbonyl-O-tert-butyl ester-L-glutamic acid, N-tert-butoxycarbonyl-O-tert-butyl ester-D-glutamic acid, N-fluorenylmethoxycarbonyl-O′-allyl ester-L-glutamic acid, N-fluorenylmethoxycarbonyl-O′-allyl ester-D-glutamic acid, N-benzyloxycarbonyl-O′-allyl ester-L-glutamic acid, N-benzyloxycarbonyl-O′-allyl ester-D-glutamic acid, N-tert-butoxycarbonyl-O′-allyl ester-L-glutamic acid, N-tert-butoxycarbonyl-O′-allyl ester-D-glutamic acid, N-tert-butoxycarbonyl-O-allyl ester-L-glutamic acid, N-tert-butoxycarbonyl-O-allyl ester-D-glutamic acid, N-fluorenylmethoxycarbonyl-L-asparagine, N-fluorenylmethoxycarbonyl-D-asparagine, N-benzyloxycarbonyl-L-asparagine, N-benzyloxycarbonyl-D-asparagine, N-tert-butoxycarbonyl-L-asparagine, N-tert-butoxycarbonyl-D-asparagine, N-fluorenylmethoxycarbonyl-L-glutamine, N-fluorenylmethoxycarbonyl-D-glutamine, N-benzyloxycarbonyl-L-glutamine, N-benzyloxycarbonyl-D-glutamine, N-tert-butoxycarbonyl-L-glutamine, N-tert-butoxycarbonyl-D-glutamine, N-fluorenylmethoxycarbonyl-O-acetyl-L-serine, N-fluorenylmethoxycarbonyl-O-acetyl-D-serine, N-benzyloxycarbonyl-O-acetyl-L-serine, N-benzyloxycarbonyl-O-acetyl-D-serine, N-tert-butoxycarbonyl-O-acetyl-L-serine, N-tert-butoxycarbonyl-O-acetyl-D-serine, N-fluorenylmethoxycarbonyl-O-benzyl-L-serine, N-fluorenylmethoxycarbonyl-O-benzyl-D-serine, N-benzyloxycarbonyl-O-benzyl-L-serine, N-benzyloxycarbonyl-O-benzyl-D-serine, N-tert-butoxycarbonyl-O-benzyl-L-serine, N-tert-butoxycarbonyl-O-benzyl-D-serine, N-fluorenylmethoxycarbonyl-O-tert-butyl-L-serine, N-fluorenylmethoxycarbonyl-O-tert-butyl-D-serine, N-benzyloxycarbonyl-O-tert-butyl-L-serine, N-benzyloxycarbonyl-O-tert-butyl-D-serine, N-tert-butoxycarbonyl-O-tert-butyl-L-serine, N-tert-butoxycarbonyl-O-tert-butyl-D-serine, N-fluorenylmethoxycarbonyl-O-allyl-L-serine, N-fluorenylmethoxycarbonyl-O-allyl-D-serine, N-benzyloxycarbonyl-O-allyl-L-serine, N-benzyloxycarbonyl-O-allyl-D-serine, N-tert-butoxycarbonyl-O-allyl-L-serine;
 N-tert-butoxycarbonyl-O-allyl-D-serine; N-fluorenylmethoxycarbonyl-O-acetyl-L-threonine, N-fluorenylmethoxycarbonyl-O-acetyl-D-threonine, N-benzyloxycarbonyl-O-acetyl-L-threonine, N-benzyloxycarbonyl-O-acetyl-D-threonine, N-tert-butoxycarbonyl-O-acetyl-L-threonine, N-tert-butoxycarbonyl-O-acetyl-D-threonine, N-fluorenylmethoxycarbonyl-O-benzyl-L-threonine, N-fluorenylmethoxycarbonyl-O-benzyl-D-threonine, N-benzyloxycarbonyl-O-benzyl-L-threonine, N-benzyloxycarbonyl-O-benzyl-D-threonine, N-tert-butoxycarbonyl-O-benzyl-L-threonine, N-tert-butoxycarbonyl-O-benzyl-D-threonine, N-fluorenylmethoxycarbonyl-O-tert-butyl-L-threonine, N-fluorenylmethoxycarbonyl-O-tert-butyl-D-threonine, N-benzyloxycarbonyl-O-tert-butyl-L-threonine, N-benzyloxycarbonyl-O-tert-butyl-D-threonine, N-tert-butoxycarbonyl-O-tert-butyl-L-threonine, N-tert-butoxycarbonyl-O-tert-butyl-D-threonine, N-fluorenylmethoxycarbonyl-O-allyl-L-threonine, N-fluorenylmethoxycarbonyl-O-allyl-D-threonine, N-benzyloxycarbonyl-O-allyl-L-threonine, N-benzyloxycarbonyl-O-allyl-D-threonine, N-tert-butoxycarbonyl-O-allyl-L-threonine, N-tert-butoxycarbonyl-O-allyl-D-threonine, N-fluorenylmethoxycarbonyl-NG-2,2,4,6,7-pentamethylbenzofuran-5-sulfonyl-L-arginine, N-fluorenylmethoxycarbonyl-NG-2,2,4,6,7-pentamethylbenzofuran-5-sulfonyl-D-arginine, N-benzyloxycarbonyl-NG-2,2,4,6,7-pentamethylbenzofuran-5-sulfonyl-L-arginine, N-benzyloxycarbonyl-NG-2,2,4,6,7-pentamethylbenzofuran-5-sulfonyl-D-arginine, N-tert-butoxycarbonyl-NG-2,2,4,6,7-pentamethylbenzofuran-5-sulfonyl-L-arginine, N-tert-butoxycarbonyl-NG-2,2,4,6,7-pentamethylbenzofuran-5-sulfonyl-D-arginine, N-fluorenylmethoxycarbonyl-N′-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-L-arginine, N-fluorenylmethoxycarbonyl-N′-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine, N-benzyloxycarbonyl-N′-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-L-arginine, N-benzyloxycarbonyl-N′-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine, N-tert-butoxycarbonyl-N′-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-L-arginine, N-tert-butoxycarbonyl-N′-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine, N-fluorenylmethoxycarbonyl-glycine, N-benzyloxycarbonyl-glycine, N-tert-butoxycarbonyl-glycine, N-fluorenylmethoxycarbonyl-β-alanine, N-benzyloxycarbonyl-β-alanine, N-tert-butoxycarbonyl-β-alanine, N-fluorenylmethoxycarbonyl-L-valine, N-fluorenylmethoxycarbonyl-D-valine, N-benzyloxycarbonyl-L-valine, N-benzyloxycarbonyl-D-valine, N-tert-butoxycarbonyl-L-valine, N-tert-butoxycarbonyl-D-valine, N-tert-butyloxycarbonyl-L-alanine, N-fluoromethoxycarbonyl-D-alanine, N-benzyloxycarbonyl-L-alanine, N-benzyloxycarbonyl-D-alanine, N-tert-butoxycarbonyl-L-alanine, N-tert-butoxycarbonyl-D-alanine, N-fluorenylmethoxycarbonyl-L-leucine, N-fluorenylmethoxycarbonyl-D-leucine, N-benzyloxycarbonyl-L-leucine, N-benzyloxycarbonyl-D-leucine, N-tert-butoxycarbonyl-L-leucine, N-tert-butoxycarbonyl-D-leucine, N-fluorenylmethoxycarbonyl-L-isoleucine, N-fluorenylmethoxycarbonyl-D-isoleucine, N-benzyloxycarbonyl-L-isoleucine, N-benzyloxycarbonyl-D-isoleucine, N-tert-butoxycarbonyl-L-isoleucine, N-tert-butoxycarbonyl-D-isoleucine, N-fluorenylmethoxycarbonyl-L-methionine, N-fluorenylmethoxycarbonyl-D-methionine, N-benzyloxycarbonyl-L-methionine, N-benzyloxycarbonyl-D-methionine, N-tert-butoxycarbonyl-L-methionine, N-tert-butoxycarbonyl-D-methionine, N-fluorenylmethoxycarbonyl-L-tyrosine, N-fluorenylmethoxycarbonyl-D-tyrosine, N-benzyloxycarbonyl-L-tyrosine, N-benzyloxycarbonyl-D-tyrosine, N-tert-butoxycarbonyl-L-tyrosine, N-tert-butoxycarbonyl-D-tyrosine, N-fluorenylmethoxycarbonyl-L-acetyltyrosine, N-fluorenylmethoxycarbonyl-D-acetyltyrosine, N-benzyloxycarbonyl-L-acetyltyrosine, N-benzyloxycarbonyl-D-acetyltyrosine, N-tert-butoxycarbonyl-L-acetyltyrosine, N-tert-butoxycarbonyl-D-acetyltyrosine, N-fluorenylmethoxycarbonyl-L-phenylalanine, N-fluorenylmethoxycarbonyl-D-phenylalanine, N-benzyloxycarbonyl-L-phenylalanine, N-benzyloxycarbonyl-D-phenylalanine, N-tert-butoxycarbonyl-L-phenylalanine, and N-tert-butoxycarbonyl-D-phenylalanine. 
 
     
     
         6 . The modified hydrophobic excipient of  claim 1 , wherein the amino protecting group is any one selected from a group consisting of fluorenylmethoxy-carbonyl (Fmoc group), benzyloxycarbonyl (Cbz group), tert-butyloxycarbonyl (Boc group), benzoyl, formyl, acetyl or trifluoroacetyl group. 
     
     
         7 . The modified hydrophobic excipient of  claim 1 , wherein the amino acid derivative is a glycine derivative or a lysine derivative. 
     
     
         8 . The modified hydrophobic excipient of  claim 7 , wherein the glycine derivative is selected from a group consisting of N-fluorenylmethoxycarbonyl-glycine, N-benzyloxycarbonyl-glycine and N-tert-butoxycarbonyl-glycine, and the lysine derivative is selected from a group consisting of N-fluorenylmethoxycarbonyl-N′-tert-butoxycarbonyl-L-lysine, N-fluorenylmethoxycarbonyl-N′-tert-butoxycarbonyl-D-lysine, N-benzyloxycarbonyl-N′-tert-butoxycarbonyl-L-lysine, N-benzyloxycarbonyl-N′-tert-butoxycarbonyl-D-lysine, N-fluorenylmethoxycarbonyl-N′-benzyloxycarbonyl-L-lysine, N-fluorenylmethoxycarbonyl-N′-benzyloxycarbonyl-D-lysine, N-fluorenylmethoxycarbonyl-N′-fluorenylmethoxycarbonyl-L-lysine, N-fluorenylmethoxycarbonyl-N′-fluorenylmethoxycarbonyl-D-lysine, N-benzyloxycarbonyl-N′-benzyloxycarbonyl-L-lysine, N-benzyloxycarbonyl-N′-benzyloxycarbonyl-D-lysine, N-benzyloxycarbonyl-N′-fluorenylmethoxycarbonyl-L-lysine, N-benzyloxycarbonyl-N′-fluorenylmethoxycarbonyl-D-lysine, N-tert-butoxycarbonyl-N′-tert-butoxycarbonyl-L-lysine, N-tert-butoxycarbonyl-N′-tert-butoxycarbonyl-D-lysine, N-tert-butoxycarbonyl-N′-fluorenylmethoxycarbonyl-L-lysine, N-tert-butoxycarbonyl-N′-fluorenylmethoxycarbonyl-D-lysine, N-tert-butoxycarbonyl-N′-benzyloxycarbonyl-L-lysine, and N-tert-butoxycarbonyl-N′-benzyloxycarbonyl-D-lysine. 
     
     
         9 . A hydrophobic excipient, wherein the molecular formula is as follows: 
       
         
           
           
               
               
           
         
         where R is a triglyceride with one to three hydroxyl groups (n=1-3) or a derivative of the triglyceride with one to three hydroxyl groups or a hydrophobic derivative of a steroid, R1 is any one selected from a group consisting of fluorenylmethoxycarbonyl (Fmoc group) or benzyloxycarbonyl (Cbz group) or tert-butoxycarbonyl (Boc group) or benzoyl or formyl or acetyl or trifluoroacetyl group, and R2 is an amino acid side chain; wherein, when m=0, R is reacted with an amino acid derivative with fluorenylmethoxycarbonyl (Fmoc group) or benzyloxycarbonyl (Cbz group) or tert-butyloxycarbonyl (Boc group) or benzoyl or formyl or acetyl or trifluoroacetyl protecting group through esterification to form the hydrophobic excipient; or when m=1, R is firstly introduced with an amino acid linking arm of different chain lengths (l=1, 2, 4, 6) via an ester group, and then introduced with a glycine derivative or a lysine derivative with a protecting group such as fluorenylmethoxycarbonyl (Fmoc group), benzyloxycarbonyl (Cbz group), tert-butyloxycarbonyl (Boc group), benzoyl, formyl, acetyl or trifluoroacetyl group to form the hydrophobic excipient. 
       
     
     
         10 . The hydrophobic excipient according to  claim 9 , wherein the natural triglyceride with one to three hydroxyl groups comprises castor oil; and the derivatives of natural triglyceride with one to three hydroxyl groups comprises hydrogenated derivatives of castor oil. 
     
     
         11 . The hydrophobic excipient according to  claim 9 , wherein the hydrophobic derivative of the steroid is selected from a group consisting of ester derivatives or amide derivatives of cholic acid, ester derivatives or amide derivatives of deoxycholic acid, ester derivatives or amide derivatives of lithocholic acid, and ester derivatives or amide derivatives of glycocholic acid. 
     
     
         12 . The hydrophobic excipient according to  claim 9 , wherein the glycine derivative is selected from a group consisting of N-fluorenylmethoxycarbonyl-glycine, N-benzyloxycarbonyl-glycine and N-tert-butoxycarbonyl-glycine; and the lysine derivative is selected from a group consisting of N-fluorenylmethoxycarbonyl-N′-tert-butoxycarbonyl-L-lysine, N-fluorenylmethoxycarbonyl-N′-tert-butoxycarbonyl-D-lysine, N-benzyloxycarbonyl-N′-tert-butoxycarbonyl-L-lysine, N-benzyloxycarbonyl-N′-tert-butoxycarbonyl-D-lysine, N-fluorenylmethoxycarb onyl-N′-benzyloxycarbonyl-L-lysine, N-fluorenylmethoxycarbonyl-N′-benzyloxycarbonyl-D-lysine, N-fluorenylmethoxycarbonyl-N′-fluorenylmethoxycarbonyl-L-lysine, N-fluorenylmethoxycarbonyl-N′-fluorenylmethoxycarbonyl-D-lysine, N-benzyloxycarbonyl-N′-benzyloxycarbonyl-L-lysine, N-benzyloxycarbonyl-N′-benzyloxycarbonyl-D-lysine, N-benzyloxycarbonyl-N′-fluorenylmethoxycarbonyl-L-lysine, N-benzyloxycarbonyl-N′-fluorenylmethoxyc arbonyl-D-lysine, N-tert-butoxycarbonyl-N′-tert-butoxycarbonyl-L-lysine, N-tert-butoxycarbonyl-N′-tert-butoxycarbonyl-D-lysine, N-tert-butoxycarbonyl-N′-fluorenylmethoxycarbonyl-L-lysine, N-tert-butoxycarbonyl-N′-fluorenylmethoxycarbonyl-D-lysine, N-tert-butoxycarbonyl-N′-benzyloxycarbonyl-L-lysine, and N-tert-butoxycarbonyl-N′-benzyloxycarbonyl-D-lysine. 
     
     
         13 . The modified hydrophobic excipient of  claim 12 , wherein the glycine derivative is selected from a group consisting of N-fluorenylmethoxycarbonyl-glycine, N-benzyloxycarbonyl-glycine and N-tert-butoxycarbonyl-glycine, and the lysine derivative is N-fluorenylmethoxyc arb onyl-N′-tert-butoxyc arbonyl-L-lysine. 
     
     
         14 . A method for preparing the modified hydrophobic excipient according to  claim 1 , characterized by subjecting a hydrophobic natural compound with one to three hydroxyl groups or a hydrophobic synthetic compound with one to three hydroxyl groups and an amino acid derivative acting as raw material, a dehydrating agent and a catalyst to an esterification reaction according to the following reaction formula to generate the modified hydrophobic excipient, where n is 1-3, 
       
         
           
           
               
               
           
         
       
     
     
         15 . The method for preparing the modified hydrophobic excipient according to  claim 14 , wherein the dehydrating agent is any one selected from a group consisting of dicyclohexylcarbodiimide (DCC), diisopropylcarbodiimide (DIC) or 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC), and the catalyst is any one selected from a group consisting of 4-dimethylaminopyridine (DMAP) and immobilized DMAP.