US2022110905A1PendingUtilityA1

Efficient anti-bacterial hydroxy acid ester oligomer

Assignee: ZHEJIANG ENMAT BIOLOGICAL TECH CO LTDPriority: Oct 26, 2020Filed: Oct 25, 2021Published: Apr 14, 2022
Est. expiryOct 26, 2040(~14.2 yrs left)· nominal 20-yr term from priority
Y02A50/30A61K 31/22C07C 69/675A61P 31/04C07C 69/68A01N 37/36A01P 1/00A01P 3/00
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Claims

Abstract

An efficient anti-bacterial hydroxy acid ester oligomer of the present invention has a general structural formula (I). Starting from the design of molecular structure, the present invention rationally designs the end group and chain length structure of the substance of formula (I), and controls its clogP value, so that the substance of formula (I) of the present invention reaches an appropriate size, which maximizes the ability of the substance of formula (I) to penetrate into the bacteria and destroy the bacterial cell membrane, thereby achieving high anti-bacterial efficiency. By precisely designing the molecular structure, the present invention regulates the hydrophilicity and hydrophobicity of the hydroxy acid ester oligomer to obtain a bio-based anti-bacterial agent with controllable water solubility.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . An anti-bacterial compound, having a general structural formula (I): 
       
         
           
           
               
               
           
         
         wherein n is a natural number of 1-8; R 1  is a C 1 -C 5  alkyl group; R 2  is a C 2 -C 8  alkyl group; m is a natural number of 0-3. 
       
     
     
         2 . The anti-bacterial compound, as recited in  claim 1 , wherein in the general structural formula (I), R 1  is a C 1 -C 2  alkyl group; R 2  is a C 5 -C 6  alkyl group; m is 0 or 1. 
     
     
         3 . The anti-bacterial compound, as recited in  claim 1 , wherein a clogP value is 1.5-3.0. 
     
     
         4 . The anti-bacterial compound, as recited in  claim 3 , wherein the clogP value is 2.0-2.5. 
     
     
         5 . The anti-bacterial compound, as recited in  claim 1 , having a general structural formula (II) or (III): 
       
         
           
           
               
               
           
         
       
       
         
           
           
               
               
           
         
       
     
     
         6 . The anti-bacterial compound, as recited in  claim 1 , wherein in the general structural formula (I), when n=1-3, R 1  is the C 1 -C 5  alkyl group, R 2  is a C 2 -C 3  alkyl group, and m is the natural number of 0-3, the anti-bacterial compound having the general structural formula (I) is a water-soluble substance. 
     
     
         7 . The anti-bacterial compound, as recited in  claim 1 , wherein in the general structural formula (I), when n=1-3, R 1  is the C 1 -C 5  alkyl group, R 2  is a C 4 -C 8  alkyl group, and m is the natural number of 0-3, the anti-bacterial compound having the general structural formula (I) is a water-insoluble substance. 
     
     
         8 . The anti-bacterial compound, as recited in  claim 1 , wherein in the general structural formula (I), when n=4-8, R 1  is the C 1 -C 5  alkyl group, R 2  is the C 2 -C 8  alkyl group, and m is the natural number of 0-3, the anti-bacterial compound having the general structural formula (I) is a water-insoluble substance. 
     
     
         9 . The anti-bacterial compound, as recited in  claim 1 , which is a water-soluble substance having a general structural formula (IV): 
       
         
           
           
               
               
           
         
         wherein n=2-3. 
       
     
     
         10 . The anti-bacterial compound, as recited in  claim 6 , which is a water-soluble substance having a general structural formula (IV): 
       
         
           
           
               
               
           
         
         wherein n=2-3. 
       
     
     
         11 . The anti-bacterial compound, as recited in  claim 1 , which is a water-insoluble substance having a general structural formula (V): 
       
         
           
           
               
               
           
         
         wherein n=4-8. 
       
     
     
         12 . The anti-bacterial compound, as recited in  claim 8 , which is a water-insoluble substance having a general structural formula (V): 
       
         
           
           
               
               
           
         
         wherein n=4-8.

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