Compositions and methods for improving gastrointestinal absorption of electrolytes

Abstract

The present disclosure relates generally to compositions and methods for improving gastrointestinal absorption function and correct deficiencies by preserving intestinal epithelial absorptive function. In particular, the compositions and methods for useful for improving gastrointestinal absorption of electrolytes.

1 . A drinkable aqueous solution comprising from about 0.5 g/L to about 20 g/L of one or more synthesized oligosaccharides selected from the group consisting of 2′-fucosyllactose, 3′-sialyllactose, 6′-sialyllactose, lacto-N-tetraose, monofucosyllacto-N-hexaose, lacto-N-fucopentaose and lacto-N-neotetraose, 150-800 mg/L of magnesium, and water, wherein the aqueous solution does not include more than about 1 g/L of lipids. 
     
     
         2 . The drinkable aqueous solution of  claim 1 , further comprising 100-1600 mg/L of sodium. 
     
     
         3 . The drinkable aqueous solution of  claim 2 , further comprising 80-800 mg/L of potassium, 
     
     
         4 . The drinkable aqueous solution of  claim 3 , further comprising 100-1000 mg/L of phosphorus and 20-800 mg/L of calcium. 
     
     
         5 . The drinkable aqueous solution of  claim 1 , which does not include more than about 5 g/L of proteins. 
     
     
         6 . The drinkable aqueous solution of  claim 5 , which does not include more than about 0.1 g/L of lipids. 
     
     
         7 . The drinkable aqueous solution of  claim 1 , wherein the lacto-N-fucopentaose is selected from the group consisting of lacto-N-fucopentaose I, lacto-N-fucopentaose II, lacto-N-fucopentaose III, lacto-N-fucopentaose IV and combinations thereof. 
     
     
         8 . The drinkable aqueous solution of  claim 1 , wherein the one or more synthesized oligosaccharides comprise 2′-fucosyllactose, 3′-sialyllactose, or the combination thereof. 
     
     
         9 . A solid composition prepared by drying the drinkable aqueous solution of  claim 1 .