Reduction of tooth staining derived from cationic antibacterials

Abstract

Disclosed are oral care compositions having reduced tooth staining propensity and comprising in a pharmaceutically acceptable carrier, a cationic antimicrobial agent and an anti-stain agent comprising one or more materials from each of at least two of the following chemical groups:Group 1. anionic agents,Group 2. aldehydes, ketones, and other reactive carbonyl compounds andGroup 3. nonionic ethoxylated surfactants.Examples of cationic antimicrobial agent include quaternary ammonium compounds such as cetylpyridinium chloride, cetyl pyridinium fluoride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride and domiphen bromide; chlorhexidine; and metal ion sources to supply metal ions such as stannous, zinc or copper.

What is claimed is: 
     
         1 . A dentifrice composition, comprising:
 a. cationic antimicrobial agent comprising stannous fluoride;   b. anionic agent comprising sodium lauryl sulfate;   c. first agent comprising pyrophosphate, tripolyphosphate, or mixtures thereof; and   d. second agent comprising flavoring agent, the flavoring agent comprising aldehyde, ketone, or mixtures thereof.   
     
     
         2 . The dentifrice composition of  claim 1 , wherein the composition comprises cocamidopropyl betaine. 
     
     
         3 . The dentifrice composition of  claim 2 , wherein the composition comprises from about 2% to about 30% of the first agent, by weight of the dentifrice composition. 
     
     
         4 . The dentifrice composition of  claim 3 , wherein the composition comprises from about 5% to about 25% of the first agent, by weight of the dentifrice composition. 
     
     
         5 . The dentifrice composition of  claim 2 , wherein the composition is a single-phase composition. 
     
     
         6 . The dentifrice composition of  claim 5 , wherein the flavoring agent comprises 4-methoxybenzaldehyde (anisaldehyde); 1,3-benzodioxole-5-carbaldehyde (heliotropin); 3,4-dimethoxybenzaldehyde (veratraldehyde); 3-methyl-1,2-cyclopentadione; phenethyl formate; acetophenone; phenylacetaldehyde; 4-methylacetophenone; ρ-toluacetaldehyde; 3,5,5-trimethyl-2-cyclohexene-1-one (isophorone); gamma-undecalactone; ρ-methyl cinnamaldehyde; 4-phenyl-2-butanone (benzyl acetone); octanal; 6-isopropyl-3-methyl-1-cyclohex-2-enone (piperitone); (S)-4-(1-methylethenyl)-1-cyclohexene-1-carboxaldehyde (perillaldehyde); 4-(1-methylethyl) benzaldehyde (cuminaldehyde); α-methyl cinnamaldehyde; isomenthone; menthone; carvone; decanal; 3-hydroxy-2-methyl-4H-pyran-4-one (maltol); ρ-isopropyl phenylacetaldehyde; trans-citral; 3-methyl-2-pentylcyclopent-2-ene-1-one (dihydrojasmone); β-napthylmethyl ketone, tiglic aldehyde, ethyl vanillin, isovaleraldehyde, or mixtures thereof. 
     
     
         7 . The dentifrice composition of  claim 5 , wherein the composition comprises saccharin. 
     
     
         8 . The dentifrice composition of  claim 7 , wherein the composition comprises titanium dioxide. 
     
     
         9 . The dentifrice composition of  claim 8 , wherein the composition comprises from about 0.25% to about 5% of the titanium dioxide, by weight of the dentifrice composition. 
     
     
         10 . The dentifrice composition of  claim 9 , wherein the flavoring agent comprises 4-methoxybenzaldehyde (anisaldehyde); 1,3-benzodioxole-5-carbaldehyde (heliotropin); 3,4-dimethoxybenzaldehyde (veratraldehyde); 3-methyl-1,2-cyclopentadione; phenethyl formate; acetophenone; phenylacetaldehyde; 4-methylacetophenone; ρ-toluacetaldehyde; 3,5,5-trimethyl-2-cyclohexene-1-one (isophorone); gamma-undecalactone; ρ-methyl cinnamaldehyde; 4-phenyl-2-butanone (benzyl acetone); octanal; 6-isopropyl-3-methyl-1-cyclohex-2-enone (piperitone); (S)-4-(1-methylethenyl)-1-cyclohexene-1-carboxaldehyde (perillaldehyde); 4-(1-methylethyl) benzaldehyde (cuminaldehyde); α-methyl cinnamaldehyde; isomenthone; menthone; carvone; decanal; 3-hydroxy-2-methyl-4H-pyran-4-one (maltol); ρ-isopropyl phenylacetaldehyde; trans-citral; 3-methyl-2-pentylcyclopent-2-ene-1-one (dihydrojasmone); β-napthylmethyl ketone, tiglic aldehyde, ethyl vanillin, isovaleraldehyde, or mixtures thereof. 
     
     
         11 . The dentifrice composition of  claim 10 , wherein the flavoring agent comprises 4-methoxybenzaldehyde (anisaldehyde); 1,3-benzodioxole-5-carbaldehyde (heliotropin); 3,4-dimethoxybenzaldehyde (veratraldehyde); 3-methyl-1,2-cyclopentadione; phenethyl formate; acetophenone; phenylacetaldehyde; 4-methylacetophenone; ρ-toluacetaldehyde; 3,5,5-trimethyl-2-cyclohexene-1-one (isophorone); gamma-undecalactone; ρ-methyl cinnamaldehyde, or mixtures thereof. 
     
     
         12 . The dentifrice composition of  claim 1 , wherein the composition comprises from about 0.05% to about 5% of the sodium lauryl sulfate, by weight of the dentifrice composition. 
     
     
         13 . The dentifrice composition of  claim 12 , wherein the composition comprises from about 2% to about 30% of the first agent, by weight of the dentifrice composition. 
     
     
         14 . The dentifrice composition of  claim 13 , wherein the composition comprises from about 5% to about 25% of the first agent, by weight of the dentifrice composition. 
     
     
         15 . The dentifrice composition of  claim 14 , wherein the composition comprises cocamidopropyl betaine. 
     
     
         16 . The dentifrice composition of  claim 15 , wherein the composition is a single-phase composition. 
     
     
         17 . The dentifrice composition according to  claim 15 , wherein the compositions comprises from about 10% to about 50% of silica abrasive, by weight of the dentifrice composition. 
     
     
         18 . The dentifrice composition of  claim 15 , wherein the flavoring agent comprises 4-methoxybenzaldehyde (anisaldehyde); 1,3-benzodioxole-5-carbaldehyde (heliotropin); 3,4-dimethoxybenzaldehyde (veratraldehyde); 3-methyl-1,2-cyclopentadione; phenethyl formate; acetophenone; phenylacetaldehyde; 4-methylacetophenone; ρ-toluacetaldehyde; 3,5,5-trimethyl-2-cyclohexene-1-one (isophorone); gamma-undecalactone; ρ-methyl cinnamaldehyde; 4-phenyl-2-butanone (benzyl acetone); octanal; 6-isopropyl-3-methyl-1-cyclohex-2-enone (piperitone); (S)-4-(1-methylethenyl)-1-cyclohexene-1-carboxaldehyde (perillaldehyde); 4-(1-methylethyl) benzaldehyde (cuminaldehyde); α-methyl cinnamaldehyde; isomenthone; menthone; carvone; decanal; 3-hydroxy-2-methyl-4H-pyran-4-one (maltol); ρ-isopropyl phenylacetaldehyde; trans-citral; 3-methyl-2-pentylcyclopent-2-ene-1-one (dihydrojasmone); β-napthylmethyl ketone, tiglic aldehyde, ethyl vanillin, isovaleraldehyde, or mixtures thereof. 
     
     
         19 . The dentifrice composition according to  claim 18 , wherein the flavoring agent comprises 4-methoxybenzaldehyde (anisaldehyde); 1,3-benzodioxole-5-carbaldehyde (heliotropin); 3,4-dimethoxybenzaldehyde (veratraldehyde); 3-methyl-1,2-cyclopentadione; phenethyl formate; acetophenone; phenylacetaldehyde; 4-methylacetophenone; ρ-toluacetaldehyde; 3,5,5-trimethyl-2-cyclohexene-1-one (isophorone); gamma-undecalactone; ρ-methyl cinnamaldehyde, or mixtures thereof. 
     
     
         20 . The dentifrice composition of  claim 19 , wherein the composition comprises zinc.