Formation and control of fluidic species

Abstract

This invention generally relates to systems and methods for the formation and/or control of fluidic species, and articles produced by such systems and methods. In some cases, the invention involves unique fluid channels, systems, controls, and/or restrictions, and combinations thereof. In certain embodiments, the invention allows fluidic streams (which can be continuous or discontinuous, i.e., droplets) to be formed and/or combined, at a variety of scales, including microfluidic scales. In one set of embodiments, a fluidic stream may be produced from a channel, where a cross-sectional dimension of the fluidic stream is smaller than that of the channel, for example, through the use of structural elements, other fluids, and/or applied external fields, etc. In some cases, a Taylor cone may be produced. In another set of embodiments, a fluidic stream may be manipulated in some fashion, for example, to create tubes (which may be hollow or solid), droplets, nested tubes or droplets, arrays of tubes or droplets, meshes of tubes, etc. In some cases, droplets produced using certain embodiments of the invention may be charged or substantially charged, which may allow their further manipulation, for instance, using applied external fields. Non-limiting examples of such manipulations include producing charged droplets, coalescing droplets (especially at the microscale), synchronizing droplet formation, aligning molecules within the droplet, etc. In some cases, the droplets and/or the fluidic streams may include colloids, cells, therapeutic agents, and the like.

What is claimed is: 
     
         1 . A microfluidic device for producing a plurality of droplets comprising:
 a first microfluidic channel for flowing a first liquid;   a second microfluidic channel for flowing a second liquid, the second microfluidic channel meeting the first microfluidic channel at a junction; and   electrodes operably associated with the junction and configured to provide an electric field at the junction to generate droplets of the first liquid within the second liquid.   
     
     
         2 . The microfluidic device of  claim 1 , further comprising a dimensional restriction in fluid communication with the first and second microfluidic channels. 
     
     
         3 . The microfluidic device of  claim 2 , wherein the dimensional restriction is less than 50% of the width of the first or second microfluidic channel. 
     
     
         4 . The microfluidic device of  claim 1 , wherein the first microfluidic channel is substantially perpendicular to the second microfluidic channel. 
     
     
         5 . The microfluidic device of  claim 1 , wherein the first liquid is conductive. 
     
     
         6 . The microfluidic device of  claim 1 , wherein the first liquid is aqueous. 
     
     
         7 . The microfluidic device of  claim 1 , wherein the second liquid is non-conductive. 
     
     
         8 . The microfluidic device of  claim 1 , wherein the second liquid is immiscible with the first liquid. 
     
     
         9 . The microfluidic device of  claim 8 , wherein the immiscible liquid is an oil. 
     
     
         10 . The microfluidic device of  claim 1 , further comprising a source of the first liquid. 
     
     
         11 . The microfluidic device of  claim 10 , wherein the first microfluidic channel comprises a dimensional restriction, and the junction is located between the source of the first liquid and the dimensional restriction. 
     
     
         12 . The microfluidic device of  claim 1 , wherein the device produces a plurality of regularly-spaced, single-file droplets. 
     
     
         13 . The microfluidic device of  claim 1 , wherein the droplets flow within the first or the second microfluidic channel. 
     
     
         14 . The microfluidic device of  claim 1 , wherein the first microfluidic channel is less than 100 microns wide. 
     
     
         15 . The microfluidic device of  claim 1 , wherein the second microfluidic channel is less than 100 microns wide. 
     
     
         16 . The microfluidic device of  claim 1 , wherein the first and second microfluidic channels are fabricated from silicon, glass, or polydimethylsiloxane. 
     
     
         17 . The microfluidic device of  claim 1 , wherein the electrodes comprise silver, gold, copper, carbon, platinum, copper, tungsten, tin, cadmium, nickel, or indium tin oxide. 
     
     
         18 . The microfluidic device of  claim 1 , wherein the droplets are charged. 
     
     
         19 . The microfluidic device of  claim 1 , further comprising an injection system configured to inject the first liquid into the first microfluidic channel and the second liquid into the second microfluidic channel. 
     
     
         20 . The microfluidic device of  claim 1 , further comprising a voltage source.