Method and composition for making an oral soluble film, containing at least one active agent

Abstract

A method of making an oral soluble film, containing at least one active agent, includes providing a well of a predetermined size; depositing a film forming composition in the well; depositing an active agent composition in the well, the active agent composition being different than the film forming composition, the film forming composition and the active agent composition forming an admixture in the well; and drying the admixture in the well. Alternatively, the method includes providing a well of a predetermined size; depositing a film forming composition including at least one active agent in the well, the film forming composition having a viscosity below 2000 centipoise; and drying the film forming composition in the well.

What is claimed is: 
     
         1 . A method of making soluble films containing at least one active agent, comprising:
 moving a substrate comprising a plurality of wells intermittently relative to a filler apparatus comprising a bank of feeder nozzles;   depositing the film forming composition comprising at least one active agent into a plurality of the wells through each of the bank of feeder nozzles using a deposit pattern matched to a dimension of the well while the substrate is stationary relative to the filler apparatus, wherein film forming composition forms a film each of the plurality of wells without mechanical intervention; and then   moving the wells containing the film forming composition to a dryer.   
     
     
         2 . The method according to  claim 1 , further comprising drying the film forming composition in the wells in the dryer using hot air currents. 
     
     
         3 . The method according to  claim 1 , further comprising forming the plurality of wells from a flat roll stock substrate prior to depositing the film forming composition, and covering and sealing the films formed in the plurality of wells, wherein forming the plurality of wells from the flat roll stock substrate, depositing the film forming composition into the plurality of wells and covering and sealing the films formed in the plurality of wells are performed on the same production line. 
     
     
         4 . A method of making soluble films containing at least one active agent, comprising depositing a film forming composition comprising at least one active agent into a plurality of wells through each of a bank of feeder nozzles using a deposit pattern matched to a dimension of the well while moving the bank of nozzles and the plurality of wells so as to have no relative speed as between bank of nozzles and the plurality of wells during depositing, wherein film forming composition forms a film each of the plurality of wells without mechanical intervention. 
     
     
         5 . The method according to  claim 4 , further comprising drying the film forming composition in the wells using hot air currents. 
     
     
         6 . The method according to  claim 4 , further comprising forming the plurality of wells from a flat roll stock substrate prior to depositing the film forming composition, and covering and sealing the films formed in the plurality of wells, wherein forming the plurality of wells from the flat roll stock substrate, depositing the film forming composition into the plurality of wells and covering and sealing the films formed in the plurality of wells are performed on the same production line.