Topical compositions

Abstract

A method of reducing oxidative damage of skin is disclosed. The method includes applying to oxidant damaged skin a topical composition comprising oligopeptide-1 and niacinamide, wherein the combination of oligopeptide-1 and niacinamide reduces oxidative damage in the skin, and wherein the oligopeptide-1 includes the sequence of caprooyl-Gly-His-Lys-Lys.

1 . A method of reducing oxidative damage of skin comprising applying to oxidant damaged skin a topical composition comprising oligopeptide-1 and niacinamide, wherein the combination of oligopeptide-1 and niacinamide reduces oxidative damage in the skin, and wherein the oligopeptide-1 comprises the sequence of caprooyl-Gly-His-Lys-Lys. 
     
     
         2 . The method of  claim 1 , wherein the oligopeptide-1 further inhibits tyrosinase, increases production of elastin, stimulates collagen production or secretion, or inhibits TNF-α; and niacinamide further inhibits melanogenesis. 
     
     
         3 . The method of  claim 1 , wherein the topical composition is applied to the skin daily. 
     
     
         4 . The method of  claim 1 , wherein the topical composition comprises 0.0000001 to 0.01% by weight of oligopeptide-1 and 0.001 to 3% by weight of niacinamide. 
     
     
         5 . The method of  claim 4 , wherein the topical composition is formulated as a sunscreen and further comprises 5 to 15% by weight of homosalate, 1 to 10% by weight each of ethylhexyl salicylate and oxybenzone, 0.1 to 10% by weight each of butyl methoxydibenzoylmethane and octocrylene, 0.1 to 5% by weight each of dicapryl carbonate, dimethicone, ammonium acryloyldimethyltaurate/VP copolymer, cetearyl alcohol, and ceteareth-25, 0.01 to 3% by weight each of disodium ethylene dicocamide PEG-15 disulfate, silica, and caprylyl glycol, and 0.01 to 1% by weight each of bisabolol, and tocopheryl acetate. 
     
     
         6 . The method of  claim 4 , wherein the topical composition is formulated as a day moisturizer and further comprises 10 to 15% by weight of isopropyl palmitate and 0.1 to 10% by weight each of glyceryl stearate, PEG-100 stearate, butylene glycol, glycerine, methyl trimethicone, silica, mica, ammonium acryloyldimethyltaurate/VP copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, isostearyl neopentanoate, cetyl phosphate, and triethanolamine. The method of  claim 4 , wherein the composition is formulated as a night moisturizer and further comprises 0.01 to 15% by weight of dimethicone, 0.01 to 10% by weight of isohexadecane, 0.1 to 10% by weight of aluminum starch octenylsuccinate, and 0.01 to 5% by weight each of caprylic/capric triglyceride, cetearyl alcohol, glyceryl stearate, butylene glycol, and hydroxyacetophenone. 
     
     
         8 . The method of  claim 4 , wherein the topical composition is formulated as a cleanser and comprises 0.1 to 10% by weight each of acrylates copolymer, cocoamidopropyl betaine, propanediol, and PPG-2-hydroxyethyl coco/isostearamide, and 0.01 to 1% by weight each of  Copernicia cerifera  (Carnauba) wax, sodium chloride, and lactose. 
     
     
         9 . The method of  claim 4 , wherein the topical composition is formulated as a foundation and further comprises 20 to 40% by weight of cyclopentasiloxane and 1 to 15% by weight each of titanium dioxide, butylene glycol, PEG-9 dimethicone, trimethylsiloxysilicate, lauryl methacrylate/glycol dimethacrylate crosspolymer, PEG/PPG-20/15 dimethicone, magnesium sulfate, and polymethylsilsesquioxane. 
     
     
         10 . The method of  claim 1 , wherein the composition is an emulsion. 
     
     
         11 . The method of  claim 1 , wherein the emulsion is an oil-in-water emulsion. 
     
     
         12 . The method of  claim 1 , wherein the composition is a cream or lotion. 
     
     
         13 . The method of  claim 1 , wherein the composition is a gel. 
     
     
         14 . The method of  claim 1 , wherein the composition is a solution. 
     
     
         15 . The method of  claim 1 , wherein the composition comprises 25 to 98% by weight of water. 
     
     
         16 . The method of  claim 1 , wherein the oxidant damage skin comprises a fine line or wrinkle.