Prediction device based on inter-organ cross talk system

Abstract

An apparatus 1 comprises a subject data obtaining unit 11 for obtaining subject data M4 of an inter-organ cross talk indicator in each organ other than a specific organ, a pattern similarity calculation unit 12 for calculating, by comparing the subject data M4 with standard data 1 of the inter-organ cross talk indicator, similarity of patterns of the inter-organ cross talk indicators, and a prediction unit 13 for predicting the presence of a specific disease and/or the stage of the specific disease by using the similarity as a measure.

What is claimed is: 
     
         1 . An apparatus for predicting the presence of a disease and/or the stage of the disease in each of one or more organs other than a specific organ in a subject affected with a disease in the specific organ, the apparatus comprising:
 a memory for storing a program;   an interface; and   a processor, during execution of the program, configured to:   obtain information about a stage of a specific disease in the specific organ of the subject;   check the information about the stage obtained against the group of the first standard data by using the search function or the filtering function of the software on database software;   extract a pattern of an inter-organ cross talk indicator in each of one or more organs other than the specific organ in the subject based on the results obtained by checking; and   predict the presence of a disease and/or the stage of the disease in each of the one or more organs other than the specific organ by using, as a measure, the pattern of the inter-organ cross talk indicator; wherein   the group of the first standard data includes patterns of the inter-organ cross talk indicators predetermined for each stage of the specific disease, each of the patterns representing a predetermined relationship between a positive control indicator and a negative control indicator, the positive control indicator being the inter-organ cross talk indicator of one of the other organs in a positive control affected with the predetermined disease, and the negative control indicator being the corresponding inter-organ cross talk indicator in a negative control without the specific disease, and   the inter-organ cross talk indicator comprises RNA or metabolites.   
     
     
         2 . The apparatus according to  claim 1 , wherein the relationship between the positive control indicator and the negative control indicator in the first standard data is a ratio between the amount of the positive control indicator and the amount of the negative control indicator. 
     
     
         3 . The apparatus according to  claim 1 , wherein the specific organ is the heart, and the specific disease is myocardial infarction. 
     
     
         4 . The apparatus according to  claim 1 , wherein the specific organ is the brain, and the specific disease is dementia. 
     
     
         5 . The apparatus according to  claim 1 , wherein the specific disease is a tumor. 
     
     
         6 . A method for predicting the presence of a disease and/or the stage of the disease in each of one or more organs other than a specific organ in a subject affected with a disease in the specific organ, the method comprising the steps of:
 (i) obtaining information about a stage of a specific disease in the specific organ in the subject from diagnostic results of the subject;   (ii) checking the information about the stage obtained in step (i) against the group of the first standard data by using the search function or the filtering function of the software on database software;   (iii) determining, from the group of the first standard data, the second standard data at a stage of the specific disease corresponding to the information about the stage, based on the checking results obtained in step (ii), and extracting, from the second standard data, a pattern of an inter-organ cross talk indicator corresponding to the stage in the subject in each of one or more organs other than the specific organ in the subject;   (iv) checking by statistical analysis the pattern of the inter-organ cross talk indicator extracted in step (iii) against known information about inter-organ cross talk indicators in diseases and/or stages of the diseases, and determining the presence of a disease and/or the stage of the disease in each of the one or more organs other than the specific organ corresponding to the pattern of the inter-organ cross talk indicator in each of the one or more organs other than the specific organ in the subject; and   (v) further determining that the disease in each of the one or more organs other than the specific organ determined in step (iv) is a disease from which the subject may be suffering, and/or   further determining that the stage of the disease in each of the one or more organs other than the specific organ determined in step (iv) is a stage of a disease from which the subject is suffering,   wherein the group of the first standard data includes patterns of the inter-organ cross talk indicators predetermined for each stage of the specific disease,   
       each of the patterns representing a predetermined relationship between a positive control indicator and a negative control indicator, the positive control indicator being the inter-organ cross talk indicator of one of the other organs in a positive control affected with the predetermined disease, and the negative control indicator being the corresponding inter-organ cross talk indicator in a negative control without the specific disease, and
 the inter-organ cross talk indicator comprises RNA or metabolites. 
 
     
     
         7 . The method according to  claim 6 , wherein the relationship between the positive control indicator and the negative control indicator in the first standard data is a ratio between the amount of the positive control indicator and the amount of the negative control indicator. 
     
     
         8 . The method according to  claim 6 , wherein the specific organ is the heart, and the specific disease is myocardial infarction. 
     
     
         9 . The method according to  claim 6 , wherein the specific organ is the brain, and the specific disease is dementia. 
     
     
         10 . The method according to  claim 6 , wherein the specific disease is a tumor.