Anti-integrin beta-1 antibody compositions and methods of use thereof

Abstract

The current invention provides human variable chain framework regions and humanized antibodies comprising the framework regions, the antibodies being specific for integrin β1. The invention also provides methods for utilizing the antibodies, for example to treat diseases such as cancer.

What is claimed is: 
     
         1 . A humanized antibody which specifically binds integrin β1 comprising a heavy chain variable (VH) region and a light chain variable (VL) region, wherein the VH region has less than about 97%, 96% or 95% identity to a VH region having an amino acid sequence as set forth in SEQ ID NO:2, and wherein the VL region has less than about 97%, 96% or 95% identity to a VL region having an amino acid sequence as set forth in SEQ ID NO:4. 
     
     
         2 . A method of treating a disease in a subject comprising administering to the subject the antibody of  claim 1 , thereby treating the disease. 
     
     
         3 . The method of  claim 2 , wherein the disease is a cell proliferative disorder. 
     
     
         4 . The method of  claim 3 , wherein the cell proliferative disorder is cancer. 
     
     
         5 . The method of  claim 4 , wherein the cancer is therapy resistant, refractory or metastatic. 
     
     
         6 . The method of  claim 3 , wherein the cell proliferative disorder is a benign or malignant tumor.