US2022081423A1PendingUtilityA1

Therapeutic compounds and methods of use thereof

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Assignee: GENENTECH INCPriority: Feb 26, 2018Filed: May 26, 2021Published: Mar 17, 2022
Est. expiryFeb 26, 2038(~11.6 yrs left)· nominal 20-yr term from priority
Inventors:Daniel P. SutherlinSteven MckerrallKwong Wah LaiZhiguo LiuWenfeng LiuRamsay BeveridgeJean-Philippe LeclercAlexandre LemireLiang ZhaoClaudio Sturino
C07B 59/002C07D 401/14A61K 31/538A61K 31/506A61K 45/06A61K 31/505C07D 263/52C07D 401/12A61K 31/63C07D 413/12C07D 403/12C07D 239/69A61P 17/04C07D 305/06C07D 233/96
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Claims

Abstract

The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain. The following compound is illustrative:

Claims

exact text as granted — not AI-modified
1 - 2 . (canceled) 
     
     
         3 . A method of treating wherein the method comprises administering to a mammal in need thereof a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof selected from the group consisting of: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         4 - 11 . (canceled) 
     
     
         12 . The method of claim  1 , wherein the compound or pharmaceutically acceptable salt is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         13 . The method of claim  1 , wherein the compound or pharmaceutically acceptable salt is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         14 . The method of claim  1 , wherein the compound or pharmaceutically acceptable salt is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         15 . The method of claim  1 , wherein the compound or pharmaceutically acceptable salt is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         16 . The method of claim  1 , wherein the compound or pharmaceutically acceptable salt is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         17 . The method of claim  1 , wherein the compound or pharmaceutically acceptable salt is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         18 . The method of claim  1 , wherein the compound or pharmaceutically acceptable salt is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         19 . The method of claim  1 , wherein the compound or pharmaceutically acceptable salt is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof.

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