Prediction device based on inter-organ cross talk system

Abstract

An apparatus 1 comprises a subject data obtaining unit 11 for obtaining subject data M 4 of an inter-organ cross talk indicator in each organ other than a specific organ, a pattern similarity calculation unit 12 for calculating, by comparing the subject data M 4 with standard data 1 of the inter-organ cross talk indicator, similarity of patterns of the inter-organ cross talk indicators, and a prediction unit 13 for predicting the presence of a specific disease and/or the stage of the specific disease by using the similarity as a measure.

What is claimed is: 
     
         1 . An apparatus for predicting efficacy or a side effect or side effects of a test substance, the apparatus comprising:
 a memory for storing a program;   an interface; and   a processor, during execution of the program, configured to:   obtain a group of predetermined standard data that serves as a measure for predicting efficacy or a side effect or side effects of the test substance;   calculate, by statistical analysis using subject data regarding an inter-organ cross talk indicator in each of one or more organs of an individual to which the test substance has been administered and the predetermined standard data corresponding to the one or more organs from which the subject data originates, similarity of patterns of the inter-organ cross talk indicators between the subject data and the predetermined standard data, wherein the subject data is derived from cells or tissue originating from each of the one or more organs, the predetermined standard data is extracted from the group of predetermined standard data,   and the inter-organ cross talk indicator comprises RNA or metabolites; and   predict efficacy or a side effect or side effects of the test substance in each of one or more organs other than the one or more organs from which the subject data originates by using, as a measure, the similarity of patterns of the inter-organ cross talk indicators.   
     
     
         2 . The apparatus according to  claim 1 , wherein the subject data is a pattern of the inter-organ cross talk indicator representing a relationship between an amount of the inter-organ cross talk indicator in the organ of the individual to which the test substance has been administered and an amount of the corresponding inter-organ cross talk indicator in the same organ in a negative control. 
     
     
         3 . The apparatus according to  claim 1 , wherein the standard data is a pattern of inter-organ cross talk indicators predetermined from amounts of inter-organ cross talk indicators whose functions are already known. 
     
     
         4 . The apparatus according to  claim 1 , wherein the standard data is a pattern of inter-organ cross talk indicators, each of the patterns being derived from a predetermined relationship between an amount of an inter-organ cross talk indicator in an organ of an individual to which an existing substance has been administered and an amount of the corresponding inter-organ cross talk indicator in the same organ in a negative control. 
     
     
         5 . The apparatus according to  claim 1 , wherein the standard data is a pattern of inter-organ cross talk indicators, each of the patterns being derived from a predetermined relationship between an amount of an inter-organ cross talk indicator in an organ of a positive control individual or positive control individuals affected with a disease and an amount of the corresponding inter-organ cross talk indicator in the same organ in a negative control. 
     
     
         6 . A method for predicting efficacy or a side effect or side effects of a test substance, the method comprising the steps of:
 (1) obtaining a group of predetermined standard data that serves as a measure for predicting efficacy or a side effect or side effects of the test substance;   (2) calculating, by statistical analysis using subject data regarding an inter-organ cross talk indicator in each of one or more organs of an individual to which the test substance has been administered and the predetermined standard data corresponding to the one or more organs from which the subject data originates, similarity of patterns of the inter-organ cross talk indicators between the subject data and the predetermined standard data, wherein the subject data is derived from cells or tissue originating from each of the one or more organs, and the predetermined standard data is obtained from the group of standard data,   and the inter-organ cross talk indicator comprises RNA or metabolites; and   (3) predicting efficacy or a side effect or side effects of the test substance in each of one or more organs other than the one or more organs from which the subject data originates by using, as a measure, the similarity of patterns of the inter-organ cross talk indicators calculated in step (2).   
     
     
         7 . The method according to  claim 6 , wherein the subject data is a pattern of the inter-organ cross talk indicator representing a relationship between an amount of the inter-organ cross talk indicator in the organ of the individual to which the test substance has been administered and an amount of the corresponding inter-organ cross talk indicator in the same organ in a negative control. 
     
     
         8 . The method according to  claim 6 , wherein the standard data is a pattern of inter-organ cross talk indicators predetermined from amounts of inter-organ cross talk indicators whose functions are already known. 
     
     
         9 . The method according to  claim 7 , wherein the standard data is a pattern of inter-organ cross talk indicators predetermined from amounts of inter-organ cross talk indicators whose functions are already known. 
     
     
         10 . The method according to  claim 6 , wherein the standard data is a pattern of inter-organ cross talk indicators, each of the patterns being derived from a predetermined relationship between an amount of an inter-organ cross talk indicator in an organ of an individual to which an existing substance has been administered and an amount of the corresponding inter-organ cross talk indicator in the same organ in a negative control. 
     
     
         11 . The method according to  claim 7 , wherein the standard data is a pattern of inter-organ cross talk indicators, each of the patterns being derived from a predetermined relationship between an amount of an inter-organ cross talk indicator in an organ of an individual to which an existing substance has been administered and an amount of the corresponding inter-organ cross talk indicator in the same organ in a negative control. 
     
     
         12 . The method according to  claim 6 , wherein the standard data is a pattern of inter-organ cross talk indicators, each of the patterns being derived from a predetermined relationship between an amount of an inter-organ cross talk indicator in an organ of a positive control individual or positive control individuals affected with a disease and an amount of the corresponding inter-organ cross talk indicator in the same organ in a negative control. 
     
     
         13 . The method according to  claim 7 , wherein the standard data is a pattern of inter-organ cross talk indicators, each of the patterns being derived from a predetermined relationship between an amount of an inter-organ cross talk indicator in an organ of a positive control individual or positive control individuals affected with a disease and an amount of the corresponding inter-organ cross talk indicator in the same organ in a negative control. 
     
     
         14 . The method according to  claim 6 , further comprising, before step (2), (i) obtaining information about the subject data regarding the inter-organ cross talk indicator in each of the one or more organs in the individual to which the test substance has been administered, the inter-organ cross talk indicator being derived from the cells or tissue originating from each of the one or more organs. 
     
     
         15 . The method according to  claim 14 , wherein step (i) comprises determining the subject data regarding the inter-organ cross talk indicator from an amount of the inter-organ cross talk indicator in each of the one or more organs of the individual to which the test substance has been administered, the inter-organ cross talk indicator being derived from the cells or tissue originating from each of the one or more organs. 
     
     
         16 . The method according to  claim 15 , wherein step (i) comprises identifying or quantifying the inter-organ cross talk indicator extracted from the cells or tissue originating from each of the one or more organs of the individual to which the test substance has been administered. 
     
     
         17 . The method according to  claim 14 , further comprising, before step (i), the steps of:
 (ii) providing the test substance;   (iii) providing the individual;   (iv) administering the test substance provided in step (ii) to the individual provided in step (iii);   (v) collecting the one or more organs from the individual administered the test substance in step (iv); and   (vi) collecting the cells or tissue from the one or more organs collected in step (v).