Pharmaceutical compositions

Abstract

Pharmaceutical compositions for oral administration, in particular administration as an oral delivery system to be swallowed directly or capable of disintegration in the oral cavity, comprising iron oxy-hydroxide in high loading.

1 . Pharmaceutical composition comprising iron oxy-hydroxide in high loading, in a form suitable for oral administration. 
     
     
         2 . Pharmaceutical composition comprising iron oxy-hydroxide in high loading, in a form suitable for oral administration as film-coated dosage forms for intact swallowing or as dosage forms capable of disintegration in the oral cavity. 
     
     
         3 - 21 . (canceled) 
     
     
         22 . A method for preparing the composition according to  claim 1  in the form of a tablet by direct compression or dry granulation. 
     
     
         23 . A method for preparing the composition according to  claim 1  in the form of a tablet, wherein an aqueous suspension, comprising at least 90% (w/w) of the ingredients based on the total weight of the final composition, is prepared, which is then subjected to spray-drying to obtain a flowable powder, which is optionally mixed with the remaining ingredients and subsequently compressed to obtain a tablet. 
     
     
         24 . A tablet, as obtainable by the method of  claim 23 . 
     
     
         25 . A tablet comprising iron oxy-hydroxide in an amount of 40 to 65% (w/w), saccharose in an amount of 5 to 30% (w/w), and starch in an amount of 5 to 30% (w/w), expressed in relation to the total weight of the tablet composition, excluding the weight of an optionally present tablet coating.