Compositions and methods for treating an infection

Abstract

A method of treating a bacterial infection of a subject includes topically administering a topical composition that includes cefixime combined with a carrier. The topical composition may be administered by contacting a tissue surface of the subject to be treated with the topical composition such as skin or mucosal tissue.

What is claimed is: 
     
         1 . A topical nail composition for topically administering to a nail to treat a bacterial nail infection comprising:
 dibasic calcium phosphate, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch, titanium dioxide, triacetin, an antibacterial agent consisting of cefixime and nitrofurantoin, and a carrier comprising an ointment, cream, gel, or lotion,   wherein the cefixime is present in a dosage amount between approximately 200 mg and approximately 400 mg,   wherein the nitrofurantoin is present in a dosage amount between approximately 25 mg and approximately 250 mg, and   wherein the and the topical composition has an ointment, cream, gel, or lotion format.   
     
     
         2 . The topical nail composition of  claim 1 , wherein the cefixime is present in a dosage amount of approximately 400 mg. 
     
     
         3 . The topical nail composition of  claim 1 , wherein the nitrofurantoin is present in a dosage amount between approximately 150 mg and approximately 200 mg. 
     
     
         4 . The topical nail composition of  claim 1 , further comprising carboxymethylcellulose sodium, anhydrous citric acid, glycerin, magnesium aluminum silicate, methylparaben, flavoring, propylparaben, purified water, saccharin sodium, sodium citrate, and sorbitol. 
     
     
         5 . The topical nail composition of  claim 4 , wherein the cefixime is present in a dosage amount of approximately 400 mg. 
     
     
         6 . A topical nail composition for topically administering to a nail to treat a bacterial nail infection comprising:
 cefixime, nitrofurantoin, dibasic calcium phosphate, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch, titanium dioxide, triacetin, and an aqueous sodium chloride solution,   wherein the cefixime is present in a dosage amount between approximately 200 mg and approximately 400 mg, and wherein the nitrofurantoin is present in a dosage amount between approximately 25 mg and approximately 250 mg.   
     
     
         7 . The topical nail composition of  claim 6 , wherein the cefixime is present in a dosage amount of approximately 400 mg. 
     
     
         8 . The topical nail composition of  claim 6 , wherein the nitrofurantoin is present in a dosage amount between approximately 150 mg and approximately 200 mg. 
     
     
         9 . The topical nail composition of  claim 6 , further comprising carboxymethylcellulose sodium, anhydrous citric acid, glycerin, magnesium aluminum silicate, methylparaben, flavoring, propylparaben, purified water, saccharin sodium, sodium citrate, and sorbitol. 
     
     
         10 . The topical nail composition of  claim 9 , wherein the cefixime is present in a dosage amount of approximately 400 mg.