Combination remedy

Abstract

The present invention primarily relates to a combination agent for reducing appetite and/or for providing a feeling of satiety and/or for reducing energy intake and/or for reducing body weight. In addition, the present invention relates to a medical use of the combination agent, in particular for the treatment of overweight and obesity and for the prevention of cardiovascular disease, stroke, diabetes, and joint damage and wear of the spine, and to a non-therapeutic use of the combination agent. In particular, the focus of the present invention is on the use of the combination agent to provide a feeling of satiety and/or to reduce energy intake and/or to reduce body weight. Finally, the present invention relates to the use of the combination agent for the preparation of an orally consumable preparation or food ingredient and an orally consumable preparation or food ingredient prepared therefrom.

1 . A combination agent comprising:
 (a) one or more first saturating component(s), optionally nonivamide;   (b) added free arginine or its isomers or derivatives; and   optionally   (c) one or more second saturation component(s), optionally a protein or a protein hydrolysate; and/or   (d) one or more sensory active substance(s).   
     
     
         2 . The combination agent of  claim 1 , wherein the one or more first saturating components are selected from the group consisting of: capsaicin, pellitorin, cinnamaldehyde, cinnamyl alcohol derivatives, nitrogen-containing cinnamic acid amide derivatives, and aromatic alkene acid derivatives, and mixtures thereof. 
     
     
         3 . The combination agent according to  claim 1 , wherein the one or more second satiating component(s) is/are protein(s) selected from the group consisting of proteins from meat (including meat from mammals, birds, reptiles, amphibians, fish), crustaceans, shellfish, mussels, molluscs, insects, eggs, milk (optionally casein and whey), algae, cereals (optionally wheat, barley, rapeseed, sunflower, rice, potatoes, corn, soybean, beans, peas, lentils, lupins, peanut, alfalfa, hemp) and other proteins from edible plants (optionally proteins with intrinsically high L-arginine content). 
     
     
         4 . The combination agent according  claim 1 , wherein the one or more second saturating component(s) is/are protein hydrolysate(s) selected from the group consisting of partial hydrolysate or complete hydrolysate of proteins from meat (including mammals, birds, reptiles, amphibians, fish), crustaceans, shellfish, mussels, molluscs, insects, eggs, milk (optionally casein and whey), algae, cereals (optionally wheat, barley, rapeseed, sunflower, rice, potatoes, corn, soybean, beans, peas, lentils, lupins, peanut, alfalfa, hemp) and other proteins from edible plants (optionally proteins with intrinsically high L-arginine content). 
     
     
         5 . The combination agent according to  claim 1 , wherein the total content of L-arginine in the combination agent according to the invention in a regularly consumable amount (serving size) comprising components (a) and (b) or components (a), (b) and (c), when present, is at least 0.1 g L-arginine, based on the total weight of the regularly consumable amount (serving size) of the combination agent. 
     
     
         6 . The combination agent according to  claim 1 , further comprising:
 (e) a carrier and/or an auxiliary means respectively an adjuvant.   
     
     
         7 . The combination agent according to  claim 1 , comprising or consisting of:
 0.00001 (0.1 ppm) to 0.001 (10 ppm) wt % of the one or more first saturation component(s);   5 to 20% by weight of added free arginine; and
 optionally 
   1 to 95% by weight of the one or more second saturation component(s); and/or   0.00001 (0.1 ppm) to 1% by weight of the one or more sensory active substance;   in each case based on the total weight of the combination agent.   
     
     
         8 . (canceled) 
     
     
         9 . A method of treating overweight and/or obesity comprising administering to a subject in need thereof a combination agent according to  claim 1 . 
     
     
         10 . A method of preventing one or more conditions in the group of cardiovascular disease, stroke, diabetes, joint damage and wear of the spine, comprising administering to a subject in need thereof a combination agent according to  claim 1 . 
     
     
         11 . (canceled) 
     
     
         12 . A method of
 (i) reducing appetite; and/or   (ii) providing a feeling of satiety; and/or   (iii) reducing energy intake; and/or   (iv) reducing body weight;   comprising administering to a subject in need thereof a combination agent according to  claim 1 .   
     
     
         13 . A method of manufacturing an orally consumable preparation or a food ingredient comprising combining the combination agent of  claim 1  with an edible ingredient. 
     
     
         14 . An orally consumable preparation or food ingredient comprising the combination agent of  claim 1 . 
     
     
         15 . The orally consumable preparation or food ingredient of  claim 14 , comprising the combination agent of  claim 1  in an amount of from 1 to 80% by weight, based on the total weight of the orally consumable preparation.