Compositions, uses and methods for treatment of infertility and subfertility

Abstract

The present invention relates i.a. to compositions which are suitable for treatment of infertility or subfertility, in particular infertility or subfertility caused by polycystic ovary syndrome (PCOS) or anovulation, or which are suitable for treatment of PCOS or anovulation itself.

1 . A method of treating or preventing infertility, subfertility, polycystic ovary syndrome (PCOS), anovulation or idiopathic infertility in a female subject, comprising administering inositol in combination with alpha lactalbumin to the female subject in need thereof. 
     
     
         2 . The method of  claim 1 , wherein the infertility or subfertility is caused by polycystic ovary syndrome (PCOS) or anovulation or wherein the infertility has its origin in idiopathic infertility. 
     
     
         3 . The method of  claim 1 , wherein the inositol and the alpha lactalbumin are administered to the subject non-simultaneously. 
     
     
         4 . The method of  claim 3 , wherein the inositol is administered to the subject prior to administering the alpha lactalbumin. 
     
     
         5 . The method of  claim 3 , wherein the inositol is administered to the subject after the alpha lactalbumin is administered to the subject. 
     
     
         6 . The method of  claim 1 , wherein the inositol and the alpha lactalbumin are administered simultaneously to the subject. 
     
     
         7 . The method of  claim 1 , wherein the inositol and alpha lactalbumin are administered in a respective weight ratio selected from the group consisting of about 1:1-50:1, about 8:1-50:1, about 30:1-50:1, about 33:1-43:1 and about 40:1. 
     
     
         8 . The method of  claim 7 , wherein the subject is administered at least one of:
 about 500-4000 mg inositol;   about 1000-3000 mg inositol;   about 2000 mg inositol;   about 10-500 mg alpha lactalbumin;   about 20-100 mg alpha lactalbumin;   about 30-70 mg alpha lactalbumin; or   about 50 mg alpha lactalbumin.   
     
     
         9 . The method of  claim 1 , wherein the inositol is selected from the group consisting of myoinositol, D-chiroinositol and mixtures thereof in any weight ratio. 
     
     
         10 . The method of  claim 1 , further comprising administering a source of folate to the female subject. 
     
     
         11 . The method of  claim 10 , wherein the source of folate is folic acid. 
     
     
         12 . The method of  claim 1 , wherein the combination of inositol and alpha lactalbumin is administered in the form of a composition comprising inositol and alpha lactalbumin. 
     
     
         13 . A method of  claim 1 , wherein the combination of inositol and alpha lactalbumin is administered as a food product or drink product. 
     
     
         14 . The method of  claim 13 , wherein the food product or drink product comprises about 2000 mg myoinositol and about 50 mg alpha lactalbumin. 
     
     
         15 . The method of  claim 13 , wherein the food product or drink product comprises about 600 mg myoinositol and about 50 mg alpha lactalbumin.