Cyclooxygenase inhibitor and calcium channel antagonist compositions and methods for use in urological procedures

Abstract

Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 
     
         1 . A method of inhibiting pain/inflammation and spasm in the urinary tract, comprising:
 delivering to the urinary tract a composition including a combination of ketoprofen and a calcium channel antagonist in a carrier, each of the ketoprofen and the calcium channel antagonist included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.   
     
     
         2 . The method of  claim 1 , wherein the composition is delivered periprocedurally to the urinary tract during a urological diagnostic, interventional, surgical and other medical procedure. 
     
     
         3 . The method of  claim 2 , wherein the composition is periprocedurally delivered during a cystoscopic procedure. 
     
     
         4 . The method of  claim 2 , wherein the composition is periprocedurally delivered during a ureteroscopic procedure. 
     
     
         5 . The method of  claim 2 , wherein the composition is periprocedurally delivered during a procedure to remove, fragment or dislodge a kidney or bladder stone. 
     
     
         6 . The method of  claim 2 , wherein the composition is periprocedurally delivered during a procedure that causes thermal injury to urinary tract tissue. 
     
     
         7 . The method of  claim 5 , wherein the composition is periprocedurally delivered during a laser, microwave ablation, radiofrequency ablation, electrocauterization or cryoblation procedure. 
     
     
         8 . The method of  claim 2 , wherein the composition is periprocedurally delivered during a transurethral resection of a prostate. 
     
     
         9 . The method of  claim 1 , wherein the calcium channel antagonist in the composition comprises nifedipine. 
     
     
         10 . A method of inhibiting pain/inflammation and spasm in the urinary tract during a diagnostic, interventional, surgical or other medical urological procedure, comprising:
 periprocedurally delivering to the urinary tract during a urological procedure a composition including a combination of ketoprofen and nifedipine in a carrier, each of the ketoprofen and the nifedipine included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.   
     
     
         11 . The method of  claim 10 , wherein the composition is during a cystoscopic procedure. 
     
     
         12 . The method of  claim 10 , wherein the composition is periprocedurally delivered during a ureteroscopic procedure. 
     
     
         13 . The method of  claim 10 , wherein the composition is periprocedurally delivered during a procedure to remove, fragment or dislodge a kidney or bladder stone. 
     
     
         14 . The method of  claim 10 , wherein the composition is periprocedurally delivered during a procedure that causes thermal injury to urinary tract tissue. 
     
     
         15 . The method of  claim 10 , wherein the composition is periprocedurally delivered during a laser, microwave ablation, radiofrequency ablation, electrocauterization or cryoblation procedure. 
     
     
         16 . The method of  claim 10 , wherein the composition is periprocedurally delivered during a transurethral resection of a prostate. 
     
     
         17 . The method of  claim 10 , wherein the composition is periprocedurally delivered transrectally or transperitoneally to the prostate. 
     
     
         18 . A method of inhibiting pain/inflammation and spasm in the urinary tract during a urological procedure, comprising:
 periprocedurally delivering to the urinary tract during a ureteroscopic procedure a composition including a combination of a cyclooxygenase inhibitor and a calcium channel antagonist in a carrier, each of the cyclooxygenase inhibitor and the calcium channel antagonist included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.   
     
     
         19 . The method of  claim 18 , wherein the cyclooxygenase (COX) inhibitor in the composition comprises a nonselective COX-1/COX-2 inhibitor.