Peptide targeting mycobacterium tuberculosis toxin-antitoxin system and use thereof

Abstract

The present invention relates to a peptide targeting a toxin-antitoxin system of Mycobacterium tuberculosis and a use thereof. Specifically, the antibiotic peptide of the present invention inhibits the formation of a toxin-antitoxin complex of Mycobacterium tuberculosis without affecting an active site of the toxin, thereby inducing the death of Mycobacterium tuberculosis by means of a separated toxin. Therefore, the antibiotic peptide can be usefully used as an antibiotic composition against Mycobacterium tuberculosis.

1 . An antibiotic peptide that inhibits the binding of an antitoxin to one or more α3 residues or α4 residues of a  Mycobacterium tuberculosis  toxin protein. 
     
     
         2 . The antibiotic peptide according to  claim 1 , wherein the toxin protein comprises the amino acid sequence represented by SEQ ID NO: 15. 
     
     
         3 . The antibiotic peptide according to  claim 1 , wherein the α3 residues consist of the 37 th  to 52 nd  amino acid sequence of VapC26. 
     
     
         4 . The antibiotic peptide according to  claim 1 , wherein the α4 residues consist of the 54 th  to 65 th  amino acid sequence of VapC26. 
     
     
         5 . The antibiotic peptide according to  claim 1 , wherein the peptide comprises one or more of the amino acid sequences represented by SEQ ID NOs: 11-13. 
     
     
         6 . The antibiotic peptide according to  claim 1 , wherein the peptide does not affect activity of a toxin. 
     
     
         7 . An antibiotic composition against  Mycobacterium tuberculosis  comprising the antibiotic peptide of  claim 1  and a carrier. 
     
     
         8 . The antibiotic composition against  Mycobacterium tuberculosis  according to  claim 7 , wherein the antibiotic peptide comprises one or more of the amino acid sequence represented by SEQ ID NOs: 11-13. 
     
     
         9 . An antibiotic quasi-drug against  Mycobacterium tuberculosis  comprising the antibiotic peptide of  claim 1 . 
     
     
         10 . The antibiotic composition against  Mycobacterium tuberculosis  of  claim 1 , formulated for external application to a subject. 
     
     
         11 . A method for ameliorating or treating a  Mycobacterium tuberculosis  infection in a subject, comprising a step of:
 administering the antibiotic peptide of  claim 1  to the subject, thereby ameliorating or treating the  Mycobacterium tuberculosis  infection of the subject.   
     
     
         12 . (canceled)