Method and system for non-invasive blood glucose measurement using signal change of the non-glucose components induced by the presence of glucose

Abstract

A method and system for detecting glucose in a biological sample is disclosed. This includes illuminating a biological sample with a light source, collecting transmitted, transflected or reflected light from the sample with a detector, generating spectral data of one or more components in the sample other than glucose in a spectral data analysis device, and analyzing the spectral data of the one or more components, sufficient to provide a glucose measurement from the spectral data of the one or more components other than glucose with the spectral data analysis device.

1 - 21 . (canceled) 
     
     
         22 . A method for measuring a blood glucose concentration comprising:
 a) illuminating a biological sample with a light beam from a light generating device; and   b) receiving and analyzing an induced change of a light signal of one or more non-blood glucose components from the sample with a detector,   wherein the induced change of the light signal is caused by physical or chemical interaction of glucose with the one or more non-blood glucose components;   wherein the analyzing of the induced change of the light signal comprises:
 generating spectral data, having peaks and valleys, of the one or more non-blood glucose components; 
 analyzing spectral data of the one or more blood components, wherein the one or more blood components are non-blood glucose; 
 wherein light absorption measured of the one or more non-blood glucose components contains a change of an absorption amount that is induced by an amount of a presence of the blood glucose which is used indirectly determine the concentration of the blood glucose. 
   
     
     
         23 . The method of  claim 22 , wherein the light generating device comprises a Laser, a light emitting diode (LED), an incandescent lamp, a halogen lamp or a combination thereof. 
     
     
         24 . The method of  claim 22 , further comprising eliminating light signal data of the one or more non-blood glucose components for changes in absorbance not related to interactions with the glucose. 
     
     
         25 . The method of  claim 22 , further comprising forming a Visible or NIR spectra using the light signal. 
     
     
         26 . The method of  claim 22 , wherein the measurement of the light absorption excludes an interference of a measurement by fat, muscle and interstitial fluid. 
     
     
         27 . A blood glucose concentration measuring device comprising:
 a) a light generating device configured to illuminate a biological sample with a light beam; and   b) a programmable computing device comprising light photocurrent sensors configured to receive and analyze an induced change of a light signal of one or more non-blood glucose components from the sample with a detector,   wherein the induced change of the light signal is caused by the physical or chemical interaction of glucose with the one or more non-blood glucose components;   wherein the programmable computing device analyzes the induced change of the light signal by:
 generating spectral data, having peaks and valleys, of the one or more non-blood glucose components; 
 analyzing spectral data of the one or more blood components, wherein the one or more blood components are non-blood glucose; 
 wherein light absorption measured of the one or more non-blood glucose components contains a change of an absorption amount that is induced by an amount of a presence of the blood glucose which is used to indirectly determine the concentration of the blood glucose. 
   
     
     
         28 . The device of  claim 27 , wherein the light generating device comprises a Laser, a light emitting diode (LED), an incandescent lamp, a halogen lamp or a combination thereof. 
     
     
         29 . The device of  claim 27 , wherein the programmable computing device is configured to eliminate the light signal data of the one or more non-blood glucose components for changes in absorbance not related to interactions with the glucose. 
     
     
         30 . The device of  claim 27 , wherein the programmable computing device is configured to form a Visible or NIR spectra using the light signal. 
     
     
         31 . The device of  claim 27 , wherein the programmable computing device is configured to avoid analyzing light signal of glucose. 
     
     
         32 . The device of  claim 27 , wherein the measurement of the light absorption excludes an interference of a measurement by fat, muscle and interstitial fluid. 
     
     
         33 . A system for detecting blood glucose in a biological sample, comprising:
 a) a light generating device configured to illuminate a biological sample comprising a plurality of blood components;   b) a detector configured to collect transmitted, transflected or reflected light from the biological sample; and   c) a computing device configured to:
 generate spectral data, having peaks and valleys, of the one or more non-blood glucose components; 
 analyze spectral data of the one or more blood components, wherein the one or more blood components are non-blood glucose; 
 wherein light absorption measured of the one or more non-blood glucose components contains a change of an absorption amount that is induced by an amount of a presence of the blood glucose which is used to indirectly determine the concentration of the blood glucose. 
   
     
     
         34 . The system of  claim 33 , wherein the light generating device comprises lasers, light emitting diodes, halogen lamps, incandescent lamps or a combination thereof. 
     
     
         35 . The system of  claim 33 , wherein the light generating device is configured to emit light in at least one of near infrared, mid-infrared and visible light regions. 
     
     
         36 . The system of  claim 33 , wherein the light generating device is configured to emit light having a wavelength in a range of 400 nm to 2500 nm. 
     
     
         37 . The system of  claim 33 , wherein the computing device is configured to mathematically compare changes in absorbance of the one or more blood components to changes in blood glucose concentration. 
     
     
         38 . The system of  claim 33 , wherein the computing device is configured to eliminate portions of the spectral data that are attributable to changes in absorbance not related to interactions with blood glucose. 
     
     
         39 . The system of  claim 33 , wherein the biological sample comprises a portion of at least one of a human finger, toe, ear lobe, tongue or arm.