Wound dressings including pvp-citric acid copolymer

Abstract

Dressings which may be useful in disrupting and/or preventing biofilm formation in a wound upon application are described, where the dressings of the present technology include a co-polymer of polyvinylpyrrolidone (PVP) and citric acid. Also disclosed herein methods employing such dressings as well as kits including such dressings.

1 . A dressing composition comprising a hydrogel, wherein the hydrogel comprises a co-polymer of polyvinylpyrrolidone (PVP) and citric acid. 
     
     
         2 . The dressing composition of  claim 1 , wherein the hydrogel comprises about 5% (w/v) to about 2.5% (w/v) co-polymer. 
     
     
         3 . The dressing composition of  claim 1 , wherein the hydrogel has a thickness of about 50 pm to about 2000 pm. 
     
     
         4 . (canceled) 
     
     
         5 . The dressing composition of  claim 1 , further comprising an absorbent material disposed adjacent to the hydrogel. 
     
     
         6 . The dressing composition of  claim 5 , wherein the absorbent material comprises a superab sorbent polymer, a non-woven carboxymethyl cellulose (CMC) pad, polyester, rayon, nylon, or a combination of any two or more thereof. 
     
     
         7 . The dressing composition of  claim 1 , further comprising a backing layer. 
     
     
         8 . The dressing composition of  claim 7 , wherein the backing layer comprises a polyurethane, a polyalkoxy alkyl acrylate, a polyalkoxy alkyl methacrylate, or a combination of any two or more thereof. 
     
     
         9 . The dressing composition of  claim 7 , wherein the thickness of the backing layer has a thickness of about 10 pm to about 1000 pm. 
     
     
         10 . The dressing composition of  claim 7 , wherein the backing layer is configured to exhibit a moisture vapor transmission rate (MVTR) of about 300 g/m 2 /24 hrs to about 20,000 g/m 2 /24 hrs. 
     
     
         11 . The dressing composition of  claim 1 , wherein dressing comprises
 a first layer comprising the hydrogel; and   a second layer comprising a mixture of a collagen and an oxidized regenerated cellulose (ORC).   
     
     
         12 .- 17 . (canceled) 
     
     
         18 . A wound dressing composition comprising:
 a mixture of a collagen, an oxidized regenerated cellulose (ORC), and a co-polymer of polyvinylpyrrolidone (PVP) and citric acid.   
     
     
         19 . The wound dressing composition of  claim 18 , wherein the co-polymer comprises a weight ratio of PVP to citric acid of about 25:1 to about 1:2. 
     
     
         20 . The wound dressing composition of  claim 18 , wherein the wound dressing composition comprises about 0.1 wt. % to about 45 wt. % of the copolymer. 
     
     
         21 . The wound dressing composition of  claim 18 , wherein the wound dressing composition comprises about 30 wt. % to about 70 wt. % ORC. 
     
     
         22 . The wound dressing composition of  claim 18 , wherein the collagen comprises a mammalian collagen. 
     
     
         23 . The wound dressing composition of  claim 18 , wherein the collagen comprises a bovine collagen, a human collagen, a recombinantly derived collagen, or a combination of any two or more thereof. 
     
     
         24 . The wound dressing composition of  claim 18 , wherein the wound dressing composition comprises about 0.1 wt. % to about 60 wt. % collagen. 
     
     
         25 . (canceled) 
     
     
         26 . A method for treating a wound in a subject in need thereof, comprising administering to the wound a dressing composition of  claim 1 . 
     
     
         27 . The method of  claim 26 , wherein the wound comprises a bio film and the dressing composition and/or the wound dressing composition prevents, reduces, inhibits, or disrupts the biofilm. 
     
     
         28 . (canceled) 
     
     
         29 . A kit comprising the dressing composition of  claim 1 , and instructions for use. 
     
     
         30 . (canceled)